Post on 02-Jun-2018
8/10/2019 Pathophysiology of CHOLELITHIASIS
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MRI RESULTS:
1. Dilated cystic side branches in directcommunication with pancreatic duct in theregion of uncinate process for which an IPMTshould be excluded
2. Multiple gallstones
3. Left renal cysts with wall calcifications
4. Tiny right renal corticocysts
5. Ascending and descending diverticula
PRECIPITATING FACTORS:Diet
ObesityRapid weight loss
Use of oral contraceptivesGallbladder, pancreatic or ileal disease
Low HDL cholesterol levelHypertriglyceridemia
CHOLELITHIASIS
Gallstones in the Bile duct
Increased Bile Cholesterol
Irritation of Gallbladdermucosa
Surface Changes
Increased Mucus Secretion
Impaired Gallbladderemptying
Precipitate out of the bile
Forms small crystals intoGallbladders mucosal surface
Enlarges to grossly visible stones
Several stones develop
PREDISPOSING FACTORS:Family History
FemaleMiddle age
8/10/2019 Pathophysiology of CHOLELITHIASIS
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Distension IntraductalPressure
RUQPain
BiliaryColic
Injury
ObstructionContractile
function
AnorexNauseVomit
Weight lFlatulenDiarrh
Fatintolera
Bileaccumulates
in Liver
IncreaseSerum
Bilirubin
Prorates/Tea-collared
UrineJaundice BiliaryCirrhosis
Bile Stasis
AbnormalFat
Digestion
I
Inflammation ofGallbladder
Cholecystitis