Organs Transplantation

Organ transplant by Alsafwa Medical Family

Why Organ transplant ??!!

organ transplant (an operation moving an organ from one organism (the donor) to another (the recipient)) "he had a kidney transplant"; "the long-term results of cardiac transplantation are now excellent"; "a child had a multiple organ transplant two months ago"

Types of transplants

• Autograft • Allograft• Isograft • Xenograft and Xenotransplantion • Split transplants • Domino transplants

Autograft

• A transplant of tissue from one to oneself. Sometimes this is done with surplus tissue, or tissue that can regenerate, or tissues more desperately needed elsewhere (examples include skin grafts, for CABG, etc.) Sometimes this is done to remove the tissue and then treat it or the person, before returning it (examples include stem-cell autograft and storing blood in advance of surgery).

Allograft • An allograft is a transplanted organ or

tissue from a genetically non-identical member of the same species. Most human tissue and organ transplants are allografts.

Isograft • A subset of allografts in which organs or

tissues are transplanted from a donor to a genetically identical recipient (such as an identical twin). Isografts are differentiated from other types of transplants because while they are anatomically identical to allografts, they are closer to autografts in terms of the recipient's immune response.

Xenograft and Xenotransplantion

• A transplant of organs or tissue from one species to another. Xenotransplantion is often an extremely dangerous type of transplant. Examples include porcine heart valves, which are quite common and successful, a baboon-to-human heart (failed), and piscine-primate (fish to non-human primate) islet (i.e. pancreatic or insular tissue), the latter's research study directed for potential human use if successful. See: xenotransplantation.

Split transplants

• Sometimes, a deceased-donor organ (specifically the liver) may be divided between two recipients, especially an adult and a child.

Domino transplants • This operation is usually performed for cystic fibrosis as

both lungs need to be replaced and it is a technically easier operation to replace the heart and lungs en bloc. As the recipient's native heart is usually healthy, this can then itself be transplanted into someone needing a heart transplant. That term is also used for a special form of liver transplant, in which the recipient suffers from familial amyloidotic polyneuropathy in which the liver (slowly) produces a protein that damages other organs; their liver can be transplanted into an older patient who is likely to die from other causes before a problem arises.

Major organs and tissues transplanted • Thoracic organs• Heart (Deceased-donor only) • Lung(Deceased-donor and Living-Donor) • En bloc Heart/Lung (Deceased-donor and Domino transplant) • Other organs• Kidney (Deceased-donor and Living-Donor) • Liver (Deceased-donor and Living-Donor) • Pancreas (Deceased-donor only) • (Deceased-donor only) • Tissues, cells, fluids• Hand (Deceased-donor only• Cornea (Deceased-donor onlySkin graft including Face transplant (almost always autograft) • Penis (Deceased-donor only) • Islets of Langerhans (Pancreas Islet Cells) (Deceased-donor and Living-Donor) • Bone marrow/Adult stem cell (Living-Donor and Autograft) • Blood transfusion/Blood Parts Transfusion (Living-Donor and Autograft) • Blood vessels (Autograft and Deceased-Donor) • Heart valve (Deceased-Donor, Living-Donor and Xenograft[Porcine/bovine]) • Bone (Deceased-Donor, Living-Donor, and Autograft) • Skin(Deceased-Donor, Living-Donor, and Autograft)

History of Organ transplant

The Chinese physician Pien Chi'ao reportedly exchanged hearts between a man of strong spirit but weak will with one of a man of weak spirit but strong will in an attempt to achieve balance in each man.

• Roman Catholic accounts report the third-century saints Damian and Cosmas as replacing the gangrenous leg of the Roman deacon Justinian with the leg of a recently deceased Ethiopian.

• The first reasonable account is of the Indian surgeon Sushruta in the second century BC, who used autografted skin transplantation in nose reconstruction rhinoplasty.

• Centuries later, the Italian surgeon performed successful skin autografts; he also failed consistently with allografts

• the first successful human corneal transplant, a keratoplastic operation, was performed by Eduard Zirm in Austria in 1905.

• Their skillful anastomosisoperations, the new suturing techniques, laid the groundwork for later transplant surgery and won Carrel the 1912 Nobel Prize for Medicine or Physiology

• Archibald McIndoe carried on the work into World War II as reconstructive surgery

• The first attempted human deceased-donor transplant was performed by the Ukrainian surgeon in the 1930s

Yu Yu Voronoy

• the late 1940s Peter Medawar, working for the National Institute for Medica Research, improved the understanding of rejection. Identifying the immune reactions in 1951 Medawar suggested that immunosuppressive drugs

• On March 9th 1981 t the first successful heart-lung transplant took place at Stanford University Hospital. The head surgeon, Bruce Reitz, credited the patient's recovery to cyclosporine-A.

Timeline of successful transpants • 1905: First successful cornea transplant by Eduard Zirm • 1954: First successful kidney transplant by Joseph Murray (Boston, U.S.A.) • 1966: First successful pancreas transplant by Richard Lillehei and William Kelly

(Minnesota, U.S.A.) • 1967: First successful liver transplant by Thomas Starzl (Denver, U.S.A.) • 1967: First successful heart transplant by Christiaan Barnard (Cape Town, South

Africa) • 1970: First successful monkey head transplant by Robert White (Cleveland, U.S.A.) • 1981: First successful heart/lung transplant by Bruce Reitz (Stanford, U.S.A.) • 1983: First successful lung lobe transplant by Joel Cooper (Toronto, Canada) • 1986: First successful double-lung transplant (Ann Harrison) by Joel Cooper

(Toronto, Canada) • 1987: First successful whole lung transplant by Joel Cooper (St. Louis, U.S.A.) • 1995: First successful laparoscopic live-donor nephrectomy by Lloyd Ratner and

Louis Kavoussi (Baltimore, U.S.A.) • 1998: First successful live-donor partial pancreas transplant by David Sutherland

(Minnesota, U.S.A.) • 1998: First successful hand transplant (France) • 2005: First successful partial face transplant (France) • 2006: First successful penis transplant (China)

Reasons for donation

Living related donors

Paired-exchange

Good Samaritan

Compensated donation

Forced donation

Ethical concerns

Who will buy ... my beautiful kidney?

Ethical concerns

• The World Health Organization argues that transplantations promote health, but the notion of “transplantation tourism” has the potential to violate human rights or exploit the poor There is also a powerful opposing view, that trade in organs, if properly and effectively regulated to ensure that the seller is fully informed of all the consequences of donation, is a mutually beneficial transaction between two consenting adults, and that prohibiting it would itself be a violation of Articles 3 and 29 of the Universal Declaration of Human Rights.

Organ transplantation in different countries

Organ transplant in Egypt

Which side are you ?!

Dialogue

In Egypt !

Thank You