CONTROLLED DRUG DELIVERY with

• Delivering pulsed or sustained release profiles at night after a defined lag period

• Adjustable lag from 1-8 hours to address specific therapeutic needs

• Works independently of pH and agitation

DELAYED DRUG RELEASE

What’s the advantage?

Tablet in tablet works independently of drug core

Can use existing core formulation allowing rapid development

Barrier layer

Pulse or sustained drug core

LIMITLESS FORMULATION OPPORTUNITIES

DELAY + PULSE eg. zaleplon for sleep

maintenance

IR + DELAY + PULSE eg. diclofenac for pain and

morning stiffness

DELAY + SR eg. verapamil for circadian

cardiovascular event

SECONDARY APPLICATIONS OF OralogiK

Colon Delivery

Sustained Release

Complex Release Profiles (biphasic / triphasic)

COLON DELIVERY Dissolution study simulating colon delivery

pH change

stomach small intestine colon

pH 1.2 pH 6.8 →

SUSTAINED RELEASE Incorporation of drug into barrier layer affords a near zero order release profile as the layer erodes

Can be combined with a pulsed release technology for BIPHASIC release

SUSTAINED RELEASE IVIVC correlation of erosion of SR formulation

COMPLEX TRIPHASIC RELEASE PROFILES Combining immediate, sustained and delayed release

4 hr SR 6 hr SR

The 3 phases can be the same or different drugs

Addition of IR dose by film coating or compression layer

Why choose OralogiK?

• Bring new consumer products affordably and quickly to market

• Bring new Rx products affordably and quickly to market

• Capitalise on your brand names with product line extension

• Patented products for lifecycle management

• Rapidly bring innovative products to the market

• Offer a novel health solution in highly competitive markets

WHAT CAN ORALOGIK DO FOR YOU

T: (+44) 141 552 8791 www.bddpharma.com