OralogiK from BDD
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Transcript of OralogiK from BDD
CONTROLLED DRUG DELIVERY with
• Delivering pulsed or sustained release profiles at night after a defined lag period
• Adjustable lag from 1-8 hours to address specific therapeutic needs
• Works independently of pH and agitation
DELAYED DRUG RELEASE
What’s the advantage?
Tablet in tablet works independently of drug core
Can use existing core formulation allowing rapid development
Barrier layer
Pulse or sustained drug core
LIMITLESS FORMULATION OPPORTUNITIES
DELAY + PULSE eg. zaleplon for sleep
maintenance
IR + DELAY + PULSE eg. diclofenac for pain and
morning stiffness
DELAY + SR eg. verapamil for circadian
cardiovascular event
SECONDARY APPLICATIONS OF OralogiK
Colon Delivery
Sustained Release
Complex Release Profiles (biphasic / triphasic)
COLON DELIVERY Dissolution study simulating colon delivery
pH change
stomach small intestine colon
pH 1.2 pH 6.8 →
SUSTAINED RELEASE Incorporation of drug into barrier layer affords a near zero order release profile as the layer erodes
Can be combined with a pulsed release technology for BIPHASIC release
SUSTAINED RELEASE IVIVC correlation of erosion of SR formulation
COMPLEX TRIPHASIC RELEASE PROFILES Combining immediate, sustained and delayed release
4 hr SR 6 hr SR
The 3 phases can be the same or different drugs
Addition of IR dose by film coating or compression layer
Why choose OralogiK?
• Bring new consumer products affordably and quickly to market
• Bring new Rx products affordably and quickly to market
• Capitalise on your brand names with product line extension
• Patented products for lifecycle management
• Rapidly bring innovative products to the market
• Offer a novel health solution in highly competitive markets
WHAT CAN ORALOGIK DO FOR YOU
T: (+44) 141 552 8791 www.bddpharma.com