LPS Stimulated MAPK Signaling

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PI3K. PC-PLC. Ras. T L R 4. Raf1. PAK1. TAK1. PKC. ASK1. IKKs. p38. NIK. MEK1/2. MEKK 1/4. MKK 3/4/6. P. P. P. P. P. P. P. P. P. P. P. ERK1/2. I k Bs Degradation. JNK1/2. SRE. CRE. Rac1. LBP. CDC42. CD14. NF- k B. NF- k B. I k Bs. SRF. c-Fos. c-Jun. Elk1. - PowerPoint PPT Presentation

Transcript of LPS Stimulated MAPK Signaling

P

LPS Stimulated MAPK Signaling

LBP

CD

14

LPS

Rac1

PAK1

MEKK1/4

MEK1/2

Raf1

CDC42PC-PLC

ASK1 TAK1

PKC

PI3K

NIK

IKKsIBs

PP P P

c-Junc-Fos c-Jun ATF2

P PP

PP

P

NF-B

Elk1 SRFCREB

ATF1 NF-B

IBsDegradation

TLR4

MKK3/4/6

p38

ERK1/2

JNK1/2

SRESRE

CRECRE

GeneExpression

GeneExpression

Ras

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