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LABORATORY ANIMAL SCIENCE MODULE 1 IN FELASA C COURSE / MEDVET1

Aurora Brønstad, Chief veterinarian, The Animal Facilities of, University of Bergen JANUAR 15-16-09!

Introduction

  Practical information about the course   Definition of laboratory animal science   Use of animal in Science in Norway   Lab animals and ethics   Lab animals and media   AIM

 http://www.uib.no/dyreavd/kurs-jan-09.htm

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Practical information

  Dyreavdelingenes web site  http://www.uib.no/dyreavd/

  Information to participant on  http://www.uib.no/dyreavd/kurs-jan-09.htm

 Compendium:  You do not need it for the first module 1  You need it for the exam in march

  MEDVET 1 (master students):  Exam after the course

  FELASA-C/B  Exam in march

Pract inf. cont.

  FELASA C course   Lectures march 2009   Exam (Written exam)   “hjemme eksamen”

finished end of the course   Practical part: 3 days within March 2009

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WHY DO YOU HAVE TO TAKE THIS COURSE ???

  §13 Planning and conducting an experiment.

  “Persons who conduct or plan experiments must have received a form of training approved by the Mattilsynet”

(Regulation on Animal Experimentation)!

Compulsory training

  The approved competent person (”ansvarshavende”) is responsible for ensuring that all personnel have the necessary training.

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FELASA categories   A Animal care personnel*   B Research technicians   C Researchers/scientists   D Laboratory animal specialists*

  *profesionals: life-long learning program

Compulsory education - researchers

  “FELASA C”  Theoretical part: 5 days/35 hours  Practical training: 3 days/ 21 hours  Self study and exam: 24 hours

  MEDVET1 Covers 12 of 35 hours theoretical part

FEDERATION OF EUROPEAN LABORATORY ANIMAL SCIENCE ASSOCIATIONS!

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http://www.uib.no/dyreavd/kurs.htm

UoB concept based on modules

Practical part - 3 days

  Aimed to be suited to the species

  Relevant techniques you work with

  Signed ”praksisattest” by manager/supervisor

  Start now finalize before exam

  Can also be obtained at “Dyreavdelingene”, contact post@viv.uib.no

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http://www.uib.no/dyreavd/kurs-jan-09.htm

”Handouts”

  All handouts can be downloaded from   http://www.uib.no/dyreavd/kurs-jan-09.htm

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Lunch

  1200-1300   You can have lunch in the cantina on the hospital or in the

BBB building.

Laboratory animal science

  Definition:  Multidisciplinary branch of science, contributing to the humane

use of animals in biomedical research and to the collection of informative unbiased and reproducible data.

  (Principles of laboratory animal science, L.F.M. van Zutphen, 2001)

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Laboratory animal science (LAS)   Includes:   Laws, regulations and laboratory animal ethics.   Characteristics of animals: anatomy, physiology, genetics

and biochemistry.   Influence of environmental factors on experimental

results.   Laboratory animal procedures and research design.

The three R’s

 Reduction  Refinement  Replacement (Russel & Burch, 1959)

Implemented in !planning &!performing !experiments !

using animals!

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Russel & Burch

 “the greatest scientific achievements have alway been the most humane and the most aesthetically attractive, conveying that sense of beauty and elegance which is the essence of science at its most successful”

 The principal of humane experimental techniques - 1959

Animals used in Norway 2006

≈48 000 Mice and rats

≈ 600 000 fish

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Animals used in Norway 2007

41 000 mice & rats

1 128 pigs 3 320 000 fish

Animals used at Vivarium 2007

728 mice 299 rats 104 pigs

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Lab animals (ex fish)

Ca 120 000 i 1982 - 50 000 i 2006

Fish Ca ”0” i 1982

2 000 000 in 1986 650 000 in 2006

Mice Ca 70 000 in 1982

35000 in 2006

Rats Ca 25 000 in 1982

13 000 in 2005

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Is it ethical to use animals in research?

Is it ethical not to use animals in research ?

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Animal experiments and media

Ethical guidelines

  Shows direction and ethical solutions   Humans are personally responsible actors

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Carrols Corporate Social Responsibility (CRP) - pyramid

Ethics vs moral

  When you have a problem and do not know what to do - then you have an ethical problem

  If you have a problem and know what you should do, but don't do it, then you have a moral problem

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Summary 1/2

  Knowledge on regulatory demands for education of personnel involved in laboratory animal research (theory part, practical part and exam)

  Know the different FELASA categories for education of lab animal personnel

  Practical information – where to find handouts and teaching material

Summary 2/2

  Know the definitions of Laboratory animal science   Knowledge of the 3R   Knowledge of number of animals used in research in

Norway   Reflection on Ethical questions   Reflection on public relations and media

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Some milestones using animals

1902 understanding of malaria life cycle pigeon 1905 study of mechanism of tuberculosis cow, sheep

1936 understanding of chemical signal transmission in nerved cat, frog, bird

1943 understanding of the role of Vitamin K rat, mice, dog chicken

1945 understanding of the curative effect of penicillium in infectious disease mice

1954 polio vaccine virus and development of vaccine monkey, mice

1966 tumor inducing virus and hormonal treatment of cancer rat, rabbit, chicken

1990 organ transplantation techniques dog

Laboratory animal science

  Definition:  Multidisciplinary branch of science, contributing to the humane

use of animals in biomedical research and to the collection of informative unbiased and reproducible data.

  (Principles of laboratory animal science, L.F.M. van Zutphen, 2001)