Hypothesis

• Estrogen and Progestrone are proctective factors against high systolic blood pressure which is a risk factor for the development of cardiovacular diseaes

How will participants be selected

• Outpatient settings i.e. doctor offices, specialty clinics

• Community centers• Public Health clinics

Why important to study/what we don’t know

• There has not been much research on estrogen and a correlation to systolic blood pressure

What we know

• Women who are postmenopausal have an increase in systolic blood to that of men near age 60-69

• Women rate of CVD increase post menopause• Boys on average have a higher systolic than

boys• Systolic stays with the person into adulthood

What pops are most affected

Study Design

• Cohort over 5 years• Population: – 500 Women and Men aged 45-65. 250 men 250

women. – 175 middle class women/men ;175 women/men

below poverty line– Non smokers for at least 8 years– Ethnicity AA Caucasion Asian-American

What comparisons will be made

• Compare levels of estrogen/progersteron via intravenous blood test

• Compare those levels of hormones to systolic blood pressure

• If a person develops CAD their out of the study DATA COLLECTED EVERY THREE MONTHS

Measures used to test hypothesis