Post on 18-Dec-2015
FAME 2 year
Objective: To investigate the 2-year outcome of PCI guided by FFR in patients with multivessel CAD.
Study: Multicenter, single blind, randomized trial.Population: Patients with stable and unstable angina and
multivessel CAD (≥ 50% DS) in native coronary arteries.
Endpoint: Composite of death, MI (Q wave, CKMB > 3xULN), any revascularization at 2 year f-up.
MVD patientsReferred for PCIn=1005
Identificationof all lesions ≥ 50%DSplanned for
PCI Angiography guidedn=509
FFR guidedPCI if FFR ≤ 0.8
n=509
FAME 2 year
22,4
3,8
9,912,9 12,7
2,6
6,18,4
10,6
17,9
0
10
20
30
Composite death MI death or MI any revasc
Angiography guided FFR guidedEvent rate at 2 year (%)
p=0.08 p=0.25 p=0.03 p=0.30p=0.02
FAME 2 year
Pijls et al. J Am Coll Cardiol 2010;56:177-84
Conclusion: FFR measurement in patients with multivessel disease undergoing PCI with DES reduces mortality and myocardial infarction at 2 years compared to angiography guided PCI.
FAME 2 year