FAME 2 year

Objective: To investigate the 2-year outcome of PCI guided by FFR in patients with multivessel CAD.

Study: Multicenter, single blind, randomized trial.Population: Patients with stable and unstable angina and

multivessel CAD (≥ 50% DS) in native coronary arteries.

Endpoint: Composite of death, MI (Q wave, CKMB > 3xULN), any revascularization at 2 year f-up.

MVD patientsReferred for PCIn=1005

Identificationof all lesions ≥ 50%DSplanned for

PCI Angiography guidedn=509

FFR guidedPCI if FFR ≤ 0.8

n=509

FAME 2 year

22,4

3,8

9,912,9 12,7

2,6

6,18,4

10,6

17,9

0

10

20

30

Composite death MI death or MI any revasc

Angiography guided FFR guidedEvent rate at 2 year (%)

p=0.08 p=0.25 p=0.03 p=0.30p=0.02

FAME 2 year

Pijls et al. J Am Coll Cardiol 2010;56:177-84

Conclusion: FFR measurement in patients with multivessel disease undergoing PCI with DES reduces mortality and myocardial infarction at 2 years compared to angiography guided PCI.

FAME 2 year