RADICAL LONGEVITY GENOMIC MEDICINE

YOU

STEVEN TUCKER, MD, FACP, FAMS Global Health Advisor, SingTel

Founder, Tucker Medical

WORD OF CAUTION

We tend to overestimate the effect of a technology in the short run and underestimate the effect in the long run.

Roy AmaraCo-founder, Institute for the Future

1EXPONENTIALS

4E+03

1E+09

2E+09

3E+09

4E+09

1974 1984 1994 2004 2014 2024

COMPUTING POWER

4E+03

1E+09

2E+09

3E+09

4E+09

1974 1984 1994 2004 2014 2024

MOORE’S LAW

4E+03

1E+09

2E+09

3E+09

4E+09

1974 1984 1994 2004 2014 2024

MOORE’S LAW

SensorsLaboratory

Genomics3D Printing

2SENSORS

SENSOR EVOLUTION

Sensor 1.0

Sensor 2.0

Sensor 3.0

Ability to measure + record signal

Sensor web integration; share + access data

Passive data gathering + aggregating + meaningful insight

ACTIVITY TRACKING

HEALTH TRACKING

MEDICAL TRACKING

EMERGENCY

STAR TREK TRICORDER

VITAL SIGNS

PACEMAKERS

CARDIAC MONITOR

DIABETES PUMP

WIRELESS BIRTH CONTROL

SMART PHONES

SENSORSGyroscope

Ambient light

Gesture

Heart rate

Accelerometer

Proximity

Compass

Barometer

Fingerprint

Hall cover

3LABORATORY

SHRINK THE LAB

THERANOS

RETAIL LABS

HOME TRACKING

HOME DIAGNOSIS

HOME DIAGNOSIS

LAB ON A CHIP

LAB ON A CHIP LEGO-STYLE

CELL CAPTURE

LIQUID BIOPSY

SMART PHONE THERMAL CYCLER

43D PRINTING

MAKERBOT

MAKERBOT

-R-3DS US

WORD OF CAUTION

We tend to overestimate the effect of a technology in the short run and underestimate the effect in the long run.

Roy AmaraCo-founder, Institute for the Future

TITANIUM LOWER JAW

FACE TRANSPLANT

NOSE + EAR

PROSTHETIC LIMBS

WORD OF CAUTION

We tend to overestimate the effect of a technology in the short run and underestimate the effect in the long run.

Roy AmaraCo-founder, Institute for the Future

3D PRINTED MEAT

MEAT MARKET

5GENOMICS

The collective noun for an organism’s hereditary

information

GENOME

DNA

GENOME MATH

23Pairs ofchromosomes

GENOME MATH

20kGenes

GENOME MATH

4Bases

A - TG - C

GENOME MATH

3.2Base pairsper genome

billion

GENOME MATH

3.2billion BP

40x Coverage

128billiondata points

SEQUENCING $

GENOMICS 2001

GENOMICS 2007

GENOMICS 2013

GENOMICS 2014

GENOMICS 2014

GENOMICS 2016

GENOMICS 2018

NEXT GEN SEQUENCING

NEXT NEXT GEN

SEQUENCING

NIPT

NIPT

NIPT

GENETIC FEAR

GENE EDITING

CRISPR - 2010

BACTERIA

MICROBIOME

MICROBIOME

100,000,000,000,000

MICROBIOME

Microbiome

The ecological community of commensal, symbiotic, and

pathogenic microorganisms that literally share our body space.

EpigenomeMICROBIOME

DATA

DATA

DATA

DATA

DATA

Epigenome

The record of the chemical changes to the DNA of an organism. Changes to the epigenome can result in changes

to the function of the genome.

DNA

EPIGENOME

Proteome

The collective set of proteins expressed by a genome, cell,

tissue or organism at a certain time.

EpigenomePROTEOME

Exposome

The collective measure of the effects of life-long environmental

exposures on health

Hg80

Cd48

33

Pb82

Ti81

Ni28

EpigenomeEXPOSOMEAs

Phenome

The collective noun for an individuals expressed phenotypic traits such as

height, skin colour, body composition, and even personality.

EpigenomePHENOME

Digital Health as Google Map

SENSOR ACTIVITY

GENOME

MICROBIOME

LAB

PHENOME

UNIQUE PERSON

DIET

HEALTH AS A GOOGLE MAP

6RADICAL

LONGEVITY

LIFE EXPECTANCY

LIFE EXPECTANCY

2050: TRIPLE THE NUMBER > 80

LONGEVITY USA

LONGEVITY USA

3m/Yr

LONGEVITY GAP

TECHNOLOGY COMPANIES

BIOLOGY COMPANIES

CALICO

HUMAN LONGEVITY

GENETIC CODE

COMPUTER CODE

4E+03

1E+09

2E+09

3E+09

4E+09

1974 1984 1994 2004 2014 2024

EXCEEDING MOORE’S LAW

4E+03

1E+09

2E+09

3E+09

4E+09

1974 1984 1994 2004 2014 2024

EXCEEDING MOORE’S LAW

GenomicsRobotics

NanotechExceed 3m/yr

IMMORTALITY ?

LIFESPAN

HEALTHSPAN

THANK  YOUFor  your  9me  &  a>en9on

www.TuckerMedical.com

@drsteventucker