Exponentials, Radical Longevity, and You
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RADICAL LONGEVITY GENOMIC MEDICINE YOU STEVEN TUCKER, MD, FACP, FAMS Global Health Advisor, SingTel Founder, Tucker Medical
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Designing healthy babies. Monitoring real-time molecular changes. Re-writing your own DNA. Bio-printing human organs from stem cells. Digestible sensors, mobile platforms, and predictive analytics. Simply put, never getting sick again. This may all sound like science fiction, but these ideas are as real today as driverless cars, private space flights, and augmented reality. In 2001, the cost of sequencing a single human genome was 100 million USD. Today that cost has fallen exponentially to under a 1000 USD. Take a moment to consider, not just how genome-based technologies will alter your future, but how they could synergistically and radically transform our definitions of health and wellness. You may plan on being financially secure at 80, but I expect you to live to 140? Assuming I am right, how can you, and your extended family, remain mentally sharp and physically fit, and disease-free?
Transcript of Exponentials, Radical Longevity, and You
RADICAL LONGEVITY GENOMIC MEDICINE
YOU
STEVEN TUCKER, MD, FACP, FAMS Global Health Advisor, SingTel
Founder, Tucker Medical
WORD OF CAUTION
We tend to overestimate the effect of a technology in the short run and underestimate the effect in the long run.
Roy AmaraCo-founder, Institute for the Future
1EXPONENTIALS
4E+03
1E+09
2E+09
3E+09
4E+09
1974 1984 1994 2004 2014 2024
COMPUTING POWER
4E+03
1E+09
2E+09
3E+09
4E+09
1974 1984 1994 2004 2014 2024
MOORE’S LAW
4E+03
1E+09
2E+09
3E+09
4E+09
1974 1984 1994 2004 2014 2024
MOORE’S LAW
SensorsLaboratory
Genomics3D Printing
2SENSORS
SENSOR EVOLUTION
Sensor 1.0
Sensor 2.0
Sensor 3.0
Ability to measure + record signal
Sensor web integration; share + access data
Passive data gathering + aggregating + meaningful insight
ACTIVITY TRACKING
HEALTH TRACKING
MEDICAL TRACKING
EMERGENCY
STAR TREK TRICORDER
VITAL SIGNS
PACEMAKERS
CARDIAC MONITOR
DIABETES PUMP
WIRELESS BIRTH CONTROL
SMART PHONES
SENSORSGyroscope
Ambient light
Gesture
Heart rate
Accelerometer
Proximity
Compass
Barometer
Fingerprint
Hall cover
3LABORATORY
SHRINK THE LAB
THERANOS
RETAIL LABS
HOME TRACKING
HOME DIAGNOSIS
HOME DIAGNOSIS
LAB ON A CHIP
LAB ON A CHIP LEGO-STYLE
CELL CAPTURE
LIQUID BIOPSY
SMART PHONE THERMAL CYCLER
43D PRINTING
MAKERBOT
MAKERBOT
-R-3DS US
WORD OF CAUTION
We tend to overestimate the effect of a technology in the short run and underestimate the effect in the long run.
Roy AmaraCo-founder, Institute for the Future
TITANIUM LOWER JAW
FACE TRANSPLANT
NOSE + EAR
PROSTHETIC LIMBS
WORD OF CAUTION
We tend to overestimate the effect of a technology in the short run and underestimate the effect in the long run.
Roy AmaraCo-founder, Institute for the Future
3D PRINTED MEAT
MEAT MARKET
5GENOMICS
The collective noun for an organism’s hereditary
information
GENOME
DNA
GENOME MATH
23Pairs ofchromosomes
GENOME MATH
20kGenes
GENOME MATH
4Bases
A - TG - C
GENOME MATH
3.2Base pairsper genome
billion
GENOME MATH
3.2billion BP
40x Coverage
128billiondata points
SEQUENCING $
GENOMICS 2001
GENOMICS 2007
GENOMICS 2013
GENOMICS 2014
GENOMICS 2014
GENOMICS 2016
GENOMICS 2018
NEXT GEN SEQUENCING
NEXT NEXT GEN
SEQUENCING
NIPT
NIPT
NIPT
GENETIC FEAR
GENE EDITING
CRISPR - 2010
BACTERIA
MICROBIOME
MICROBIOME
100,000,000,000,000
MICROBIOME
Microbiome
The ecological community of commensal, symbiotic, and
pathogenic microorganisms that literally share our body space.
EpigenomeMICROBIOME
DATA
DATA
DATA
DATA
DATA
Epigenome
The record of the chemical changes to the DNA of an organism. Changes to the epigenome can result in changes
to the function of the genome.
DNA
EPIGENOME
Proteome
The collective set of proteins expressed by a genome, cell,
tissue or organism at a certain time.
EpigenomePROTEOME
Exposome
The collective measure of the effects of life-long environmental
exposures on health
Hg80
Cd48
33
Pb82
Ti81
Ni28
EpigenomeEXPOSOMEAs
Phenome
The collective noun for an individuals expressed phenotypic traits such as
height, skin colour, body composition, and even personality.
EpigenomePHENOME
Digital Health as Google Map
SENSOR ACTIVITY
GENOME
MICROBIOME
LAB
PHENOME
UNIQUE PERSON
DIET
HEALTH AS A GOOGLE MAP
6RADICAL
LONGEVITY
LIFE EXPECTANCY
LIFE EXPECTANCY
2050: TRIPLE THE NUMBER > 80
LONGEVITY USA
LONGEVITY USA
3m/Yr
LONGEVITY GAP
TECHNOLOGY COMPANIES
BIOLOGY COMPANIES
CALICO
HUMAN LONGEVITY
GENETIC CODE
COMPUTER CODE
4E+03
1E+09
2E+09
3E+09
4E+09
1974 1984 1994 2004 2014 2024
EXCEEDING MOORE’S LAW
4E+03
1E+09
2E+09
3E+09
4E+09
1974 1984 1994 2004 2014 2024
EXCEEDING MOORE’S LAW
GenomicsRobotics
NanotechExceed 3m/yr
IMMORTALITY ?
LIFESPAN
HEALTHSPAN
THANK YOUFor your 9me & a>en9on
www.TuckerMedical.com
@drsteventucker
