• P450 enzymes breakdown/metabolize active drug

P450 enzymes

P450 enzymes

P450 enzymes

Active Drug Inactive drug

Enzyme

P450 enzymes

P450 enzymes

P450 enzymes

Inhibitors slow the enzyme Increase drug concentration

Inhibitors slow p450Active Drug is increased

• Inducers increased metabolism

• Reduce drug concentration

Active Drug Inducers

Speed p450

is decreased

• Inducers increased the enzyme

• Reduce drug concentration