Enzymes and drugs

5

description

Enzymes and drugs. P450 enzymes. P450 enzymes. P450 enzymes. Active Drug. Enzyme. Inactive drug. P450 enzymes breakdown/metabolize active drug. P450 enzymes. P450 enzymes. P450 enzymes. Inhibitors slow p450. Active Drug. is increased. Inhibitors slow the enzyme - PowerPoint PPT Presentation

Transcript of Enzymes and drugs

Page 1: Enzymes and drugs
Page 2: Enzymes and drugs

• P450 enzymes breakdown/metabolize active drug

P450 enzymes

P450 enzymes

P450 enzymes

Active Drug Inactive drug

Enzyme

Page 3: Enzymes and drugs

P450 enzymes

P450 enzymes

P450 enzymes

Inhibitors slow the enzyme Increase drug concentration

Inhibitors slow p450Active Drug is increased

Page 4: Enzymes and drugs

• Inducers increased metabolism

• Reduce drug concentration

Active Drug Inducers

Speed p450

is decreased

Page 5: Enzymes and drugs

• Inducers increased the enzyme

• Reduce drug concentration


Enzymes and Biological

Enzymes and Biological

ORGANIC CHEMISTRY AND ENZYMES EQ: What kind of organic compound are enzymes and what do enzymes do?

ORGANIC CHEMISTRY AND ENZYMES EQ: What kind of organic compound are enzymes and what do enzymes do?

Enzymes as Biological Catalysts Nomenclature and Names of Enzymes Nature of Enzymes Enzyme Cofactors Classification of Enzymes Mechanism of.

Enzymes as Biological Catalysts Nomenclature and Names of Enzymes Nature of Enzymes Enzyme Cofactors Classification of Enzymes Mechanism of.

Research Paper TFEB ameliorates the impairment of …...synaptic components, such as synaptic receptors and enzymes [4-10]. In addition, chemotherapy drugs, such as paclitaxel and

Research Paper TFEB ameliorates the impairment of …...synaptic components, such as synaptic receptors and enzymes [4-10]. In addition, chemotherapy drugs, such as paclitaxel and

Jeopardy! Cell Transport and Enzymes Jeopardy! Cell Transport and Enzymes.

Jeopardy! Cell Transport and Enzymes Jeopardy! Cell Transport and Enzymes.

Blood, Sweat and Tears Darkfield, Enzymes and … Sweat and Tears Darkfield, Enzymes...are eating- Pharmaceutical drugs are ... aids in tbe breakdown of fat. ... About Vitamins & Antioxidants

Blood, Sweat and Tears Darkfield, Enzymes and … Sweat and Tears Darkfield, Enzymes...are eating- Pharmaceutical drugs are ... aids in tbe breakdown of fat. ... About Vitamins & Antioxidants

BIOTRANSFORMATION AND METABOLISM BIOTRANSFORMATION: Drugs being metabolized by enzymes and chemical reactions in the body before they are eliminated. Altered.

BIOTRANSFORMATION AND METABOLISM BIOTRANSFORMATION: Drugs being metabolized by enzymes and chemical reactions in the body before they are eliminated. Altered.

Prediction of Drug-Target Interactions and Drug ...lliao/cis889f12/papers/... · data sets with known drugs targeting enzymes, ion channels, GPCRs, and nuclear receptors respectively,

Prediction of Drug-Target Interactions and Drug ...lliao/cis889f12/papers/... · data sets with known drugs targeting enzymes, ion channels, GPCRs, and nuclear receptors respectively,

Drug Metabolism and more TDM - hodsdon.com · Drug Metabolism and more TDM ... – “Pro‐drugs” are activated by metabolic ... elevated liver enzymes, coagulation defects, encephalopathy,

Drug Metabolism and more TDM - hodsdon.com · Drug Metabolism and more TDM ... – “Pro‐drugs” are activated by metabolic ... elevated liver enzymes, coagulation defects, encephalopathy,

Antifungal Drugs I. Humans and fungi share a common biosynthetic pathway for sterols from squalene (via squalene 2,3 epoxidase and other enzymes) to lanosterol.

Antifungal Drugs I. Humans and fungi share a common biosynthetic pathway for sterols from squalene (via squalene 2,3 epoxidase and other enzymes) to lanosterol.

ISSN: 2519-9889 Enzymes and Protein Drugs - An Overviewd.researchbib.com/f/4nnJcjp20hL29gY1O1Lzkcp2... · the enzymes and protein containing crude drugs. Keywords: Enzymes, plasma,

ISSN: 2519-9889 Enzymes and Protein Drugs - An Overviewd.researchbib.com/f/4nnJcjp20hL29gY1O1Lzkcp2... · the enzymes and protein containing crude drugs. Keywords: Enzymes, plasma,

Enzymes and inhibition

Enzymes and inhibition

Enzymes Objective: Identify and understand the role of enzymes.

Enzymes Objective: Identify and understand the role of enzymes.

PHARM 630 - sites.ualberta.caaelkadi/DMP/4.pdf9 Induction of Drug Metabolism-Many drugs and chemicals can induce drug metabolizing enzymes upon repeated exposure/administration. -

PHARM 630 - sites.ualberta.caaelkadi/DMP/4.pdf9 Induction of Drug Metabolism-Many drugs and chemicals can induce drug metabolizing enzymes upon repeated exposure/administration. -

University of ZurichDrug action depends on how drugs are metabolized and differences in activity of metabolizing enzymes can signif-icantly contribute to the efficacy of drugs [1,2].

University of ZurichDrug action depends on how drugs are metabolized and differences in activity of metabolizing enzymes can signif-icantly contribute to the efficacy of drugs [1,2].

Supplementary Materials forscience.sciencemag.org/highwire/filestream/685969/... · Supplemental Tables Pathway with enzymes ay reactions reactions enzymes enzymes enzymes of enzymes

Supplementary Materials forscience.sciencemag.org/highwire/filestream/685969/... · Supplemental Tables Pathway with enzymes ay reactions reactions enzymes enzymes enzymes of enzymes

Protein(design · • Designing enzymes (proteins that catalyze chemical reactions) – Useful for production of industrial chemicals and drugs • Designing proteins that bind specifically

Protein(design · • Designing enzymes (proteins that catalyze chemical reactions) – Useful for production of industrial chemicals and drugs • Designing proteins that bind specifically

Enzymes Honors Biology Chemical Reactions and Enzymes chemical reaction:

Enzymes Honors Biology Chemical Reactions and Enzymes chemical reaction:

Enzymes and Bioremedation

Enzymes and Bioremedation

Pharmacology/Therapeutics I Lectures · Pharmacology/Therapeutics I Block 2 Lectures ... Therapeutic drugs can inhibit enzymes involved in ... (except for gases and some nucleosides)

Pharmacology/Therapeutics I Lectures · Pharmacology/Therapeutics I Block 2 Lectures ... Therapeutic drugs can inhibit enzymes involved in ... (except for gases and some nucleosides)