Could genomics save the world?

Will Spooner, CTO, Founder, Eagle Genomics Ltd William.spooner@eaglegenomics.com

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Famine Disease

Image: A. Cavanagh http://images.wellcome.ac.uk/ CC-BY-ND 2.0

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SyntheticLife

Gaia

Image http://ginosblog.com/2010/06/03/100-synthetic-life-is-a-babystep-away/ CC-BY-NC-SA

Molecular Psychiatry advance online publication 30 August 2011; doi:10.1038/mp.2011.101

Scientific impact of genomics

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Phen

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PhenotypicAssociation[biomarker]

Stratified Medicine

Right drug

Right patient

Right time

Pharmacogenomics

Genotypic

Transcriptomic

Epigenetic

Genomics in medicine

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Genomics in plant breedingGermplasm/Pedigree

Phenotype/Genotype association

Phenotype Genotype

GenotypingPhenotyping

Assays

Breeding

NGS - democratising genomics

$1000 genome~$0.01 Mbase (30x coverage)

50,000 core supercomputer$1,600/HOUR

Cloud – democratising HPC

Doing Genomics Efficiently

• “Genome Content Management is the set of processes and technologies that support the creating, managing, and reporting of genomic data.”

Create

Man

ag

e

Report

Create

Report

Ext

end

Manage

Share

Reuse

TIMELINE: Bespoke……...Common Models……………Content Management Systems

Open Innovation

ExploreWork together to find a commonpurpose

NurtureBuild trust, shared language

ExploitTurn ideas intotangible benefits

CollaborateEnterpriseAcademiaGovernmentFoundations

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–In under a month (June 2011);• 10 e coli isolates sequenced,• 9 genome assemblies released,• 16 genome annotations released,•Over 50 analyses performed,• Resulting in 12 citable publications

Can genomics save the world?

• Genomics is revolutionising:– Basic research, – Plant breeding, – Healthcare.

• Genomics R&D is empowered by:– NGS, – Cloud computing,

• Collaboration is key– Open knowledge/science,– Public datasets,– Open innovation.

Eagle Genomics

Genome Content ManagementIntegrated, Analysed, Validated,

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