© TND 2005

Brain Imaging in ADBrain Imaging in AD

Mony J. de Leon

Professor of Psychiatry

Center for Brain Health

NYU School of Medicine

NY NY 10016

mony.deleon@med.nyu.edu

© TND 2005

General Atrophy in Alzheimer’s Disease

© TND 2005

© TND 2005

© TND 2005

Brain Staging Model for ADBrain Staging Model for AD

NormalNormal

MCIMCI

ADAD

Entorhinal CortexEntorhinal Cortex

HippocampusHippocampus

Temporal NeocortexTemporal Neocortex

© TND 2005

© TND 2005

© TND 2005

© TND 2005

© TND 2005

© TND 2005

© TND 2005

© TND 2005

© TND 2005

© TND 2005

© TND 2005

© TND 2005

© TND 2005

© TND 2005

ConclusionsConclusions

• In vivo imaging is of use in the early identification of brain changes associated with AD.

• The patterns of imaged brain changes appear to first involve the entorhinal cortex, then the hippocampus, and later the neocortex.