8/2/2019 Biological Monitoring of Exposure to Formaldehyde by Roberto Bono

1/19

Gjyca{fc daulgjikcrik bx ug~bijr

gexaueki* yck ks~axbybao ya by

bx oay kgxbjr gxxkxxgejk er ibukhylkgx{uklkoy bo ebajafbhgj dj{bix/

Ycbx bx ekhg{xk yck eba,gtgbjgejk

~auybao ad daulgjikcrik bx

ug~bijr lkygeajbpki goi byx

lkygeajbykx guk kbyckubohau~augyki boya

lghualajkh{jkx tbg yck aok,

hgueao ~aaj ~gycvgr au

kjblbogyki vbyc yck ks~buki gbu

#HA5" goi {ubok/

daulgjikcrik

X,criuasrlkycrj,fj{ygybaok

X,daulrjfj{ygybaok

Daulbh ghbi

HA5 - C5A

#kscgjki"Og- CHAA,

#{ubok"

Uaekuya Eaoauaekuya/eaoaN{obya/by

Ebajafbhgj laobyaubof ad ks~ax{uk yadaulgjikcrik/ Ibddkukoy lkhcgobxlxad ghybao= daulgybao ad ~uaykbo gii{hy

goi ktbikohk ad asbigybtk xyukxx

8/2/2019 Biological Monitoring of Exposure to Formaldehyde by Roberto Bono

2/19

daulgjikcrik bx go

ksyuklkjr ukghybtkhcklbhgj daulboflkycrjkok eubifkx

goi ~uai{hbofhatgjkoyjr Huaxx,

jbomki hal~jkskxvbyc ^uaykbo goiIOG #I^Hx" vcbhc

hgo ek lkgx{uki boejaai au hkjjx adks~axki x{e`khyx/

Ycbx vkjj,moavo dbf{uk ad ~uad/ Eajy uklboix {x ycgy daulgjikcrik gjxa lgr ukghyxoao , koprlgybhgjjr vbyc x{jdcriurj fua{~x* {ukg* au glboa fua{~x0

G~guy dual yck kshukyki hal~aokoy*

Xbohk gii{hyx ekyvkko daulgjikcrikgoi ~uaykbox guk oay x{e`khyki ya

uk~gbu lkhcgobxlx* yckbu ~ukxkohkhauukx~aoix ya yck jbdk ad yck ~uaykbo

goi yckbu ge{oigohk bx ~ua~auybaogj yaks~axbybao/

8/2/2019 Biological Monitoring of Exposure to Formaldehyde by Roberto Bono

3/19

U,HCA - C5O,Tgj,Ce U,HC < O,Tgj,Ce - C5AGjikcrik - O,ykulbogj tgjbok O,ykulbogj tgjbok gii{hy

Mg{ybgboko* G/* Yuowtbxy* L/* Xtkoxxao* M/* Axykulgo,Fajmgu* X/* Oatkleku 7232/ Gii{hyx ad lgjaogjikcrik goi g dkvaycku gjikcrikx ya cklafjaebo/ Hguhboafkokxbx 7> #77"* 5758578>/

Mg{ybgboko ~{ejbxcki bo 7232 yck

iklaoxyugybao ycgy yck gjikcrikxeboi uktkuxbejr ya ~ublgur glboa

fua{~x x{hc gx* yck O,ykulbogjtgjbok ad cklafjaebo* ycua{fc yckdaulgybao ad yck hauukx~aoibof

Xhcbdd egxk/ Yck O,ykulbogj tgjbokad fjaebo lgr gjxa {oikufa

gjmrjgybao* daulbof O,lkycrjkotgjbok/ Yck daulgybao adycbx kgujr ebajafbhgj lgumku bx

ik~koikoy ao yck ks~axbybao yatguba{x gjmrjgybof gfkoyx* glaofvcbhc daulgjikcrik uk~ukxkoy g

xbfobdbhgoy ksgl~jk/

8/2/2019 Biological Monitoring of Exposure to Formaldehyde by Roberto Bono

4/19

Bo ~ughybhk* daulgjikcrik ukghyx vbyc cklafjaebo ya daul yck O,lkycrjkotgjbok

#{oxygejk"* vcbhc bx x{exkw{koyjr uki{hki ya O,lkycrjtgjbok* xygejk goi lkgx{ugejk/

Dau kghc xgl~jk yck ~uahki{uk ya lkgx{uk yck lkycrjkotgjbok bx g~~jbki yvbhk0

Bo yck dbuxy g~~jbhgybao* ;> lf ad iurfjaebo guk {xki ya aeygbo yck

eghmfua{oi O,lkycrjtgjbok

Bo yck xkhaoi g~~jbhgybao* yckfjaebo bx uki{hki ya aeygbo yck

yaygj O,lkycrjtgjbok

uki{hybao #OgEC9"

DG - Ce O,lkycrjkotgjbok O,lkycrjtgjbok

HC5 < O,Tgj,Ce HC8OC,Tgj,Ce

Ya gjjav ghh{ugyk ikykulbogybao* yck {oxygejk Xhcbdd egxk xca{ji ek yugoxdaulki yaxkhaoigur glbok er uki{hybao vbyc xaib{l eauacriubik #OgEC9"/

uki{hybao #OgEC9"

U,HC < O,Tgj,Ce U,HC5OC,Tgj,CeO,ykulbogj #tgjbok" gii{hy uki{hki O,ykulbogj #tgjbok" gii{hy

8/2/2019 Biological Monitoring of Exposure to Formaldehyde by Roberto Bono

5/19

O,lkycrjtgjbok* aeygboki er yck uki{hybao ad O,lkycrjkotgjbok halbof dual yck

gjmrjgybof ghybtbyr ad daulgjikcrik* bx aeygboki er x{eyughybof yck koiafkoa{x#eghmfua{oi" O,lkycrjtgjbok lkgx{uki yck dbuxy yblk dual yck yaygj O,lkycrjtgjbokukx{jybof dual yck uki{hybao lkgx{uki yck xkhaoi yblk/

uki{hybao #OgEC9"

daulgjikcrik - Ce O,lkycrjkotgjbok O,lkycrjtgjbok

{oxygejk #oao vkjj lkgx{ugejk" xygejk #lkgx{ugejk"

g o{lkubhgj ksgl~jk

5; < 8;7>

yaygj O,lkycrjtgjbok

#eghmfua{oi O,lkycrjtgjbok -O,lkycrjkotgjbok uki{hki ya

O,lkycrjtgjbok"

eghmfua{oi#koiafkoa{x"

O,lkycrjtgjbok

O,lkycrjtgjbokhauukx~aoibof ya

O,uki{hkilkycrjkotgjbok

, H {oybj gogjrxbx* {ubok vkuk xyauki gy 3> H {oybj yck haybobok gogjrxbx* ejaai xgl~jkx vkuk yukgyki ya ~uai{hk iubki fjaebo goi xyauki gy 3> H/

8/2/2019 Biological Monitoring of Exposure to Formaldehyde by Roberto Bono

10/19

yck lkgo gfk ad yckxkycukk fua{~x vkukhal~gugejk* goi gorxygybxybhgj ibddkukohkxvkuk ukhauiki

Glaof yck 99

~gycajafbxyx* yck 72vaumbof bo uki{hybaouaalx* vckuk

daulgjikcrik bx ibukhyjr{xki* xcavki g

xygybxybhgjjr xbfobdbhgoycbfcku ks~ax{uk

#~:>/>>>7"* {ojbmk yckaokx vaumbof bo aycku

xkutbhkx #o/ 5;"/

Haotkuxkjr* yckxk 5;jgxy x{e`khyx xcavxblbjgu tgj{kx ycgo

haoyuajx/ Haoxkw{koyjr*yckr vkuk bohj{iki boya

yck haoyuaj fua{~/

63 - 5; < 7>8

Yck ukx{jybof dbogjhal~axbybao ad

fua{~x hal~ubxki72 ~gycajafbxyx* ;7

~jgxybh jglbogykvaumkux* goi 7>8

haoyuajx/

Gor xbfobdbhgoy ibddkukohkx vkuk g~~ukhbgyki glaof yck

koiafkoa{x O,lkycrjtgjbok ad gjj yck 768 x{e`khyx/

8/2/2019 Biological Monitoring of Exposure to Formaldehyde by Roberto Bono

11/19

Hauukjgybao ekyvkko o{lekux ad hbfgukyykx xlamki ~ku igr goi

haybobok jktkjx glaof yck gjj768 x{e`khyx #^kguxao ykxy" xcavki xyuaofgoi cbfcjr xbfobdbhgoy hauukjgybao0 u < >/379* ~ : >/>>>7* gx ks~khyki/

8/2/2019 Biological Monitoring of Exposure to Formaldehyde by Roberto Bono

12/19

G fkokugj ibddkukohk ekyvkko yckycukk botkxybfgyki fua{~x vgx

aexkutki #~ : >/>>>7" daudaulgjikcrik goi O,lkycrjkotgjbok/

G xbfobdbhgoyjr cbfckuhaohkoyugybao ad yckxk lgumkuxdau yck ks~axki vaumkux #O/7 #5/54;" 97/9 #7/;>6"

GOATG ~:>/>>>7/ Y{mkr0#72 tx ;7" O/X/ , #72 tx 7>8" :>/>>>7 , #;7 tx 7>8" : >/>>>7 , #6> tx 7>8" y,ykxy : >/>>>7

Ks~axki ya daulgjikcrik

Haoyuajxg

7>8

O laj!f fjaebo

#jaf,yugoxd/"

^gycajafbxyx

72

^jgxybhjglbogykvaumkux

;7

lkibgo 842/8 #5/;46" 563/9 #5/99;" 4;/3#7/373"

Lkgo 866/2 #5/84;" 895/3 #5/95>" 799/3#7/682"

GOATG ~: >/>>>7/ Y{mkr0 #72 tx ;7" O/X/ , #72 tx 7>8" :>/>>>7 , #;7 tx 7>8" : >/>>>7 , #6> tx 7>8" , y,ykxy : >/>>>7

xblbjgu jktkjx ad ks~axbybao yadaulgjikcrik ~uai{hk xblbjguebajafbhgj ukx~aoxk ikx~byk yckuklgumgejk ibddkukohkx ekyvkkoyck yva ~uadkxxbaox/

g ukdkukohk hgykfaur

8/2/2019 Biological Monitoring of Exposure to Formaldehyde by Roberto Bono

13/19

{ubogur haybobok ao yckvcajk ~a~{jgybao{oikujbokx g fkokugj

ibddkukohk ekyvkko yck

ycukk jktkjx adks~axbybao botkxybfgyki#~ : >/>>5"

Ks~axki ya daulgjikcrik

Haoyuajxg

7>8of!lj

#jaf,yugoxd/"

^gycajafbxyx

72^jgxybh jglbogykvaumkux

;7

lkibgo 3/> #>/2>8" 9;/> #7/4;8" 7>/> #7"

Lkgo 9>2/7 #7/;57" 6>9/8 #7/629" 752/4 #7/749"

X/I/ 6>4/> #7/>64" 2;9/5 #7/563" 8>6/9 #>/346"

GOATG ~ < >/>>5/ Y{mkr0#72 tx ;7" O/X/ , #72 tx 7>8" O/X/ ,

#;7 tx 7>8" < >/>>7 , #6> tx 7>8" y,ykxy ~ < >/>>7

Ao yck vcajk* g cbfcku jktkj ad yaeghha haox{l~ybao bx haodbulki bo ks~axki

x{e`khyx ycgo bo haoyuajx #~ < >/>>7"

g ukdkukohk hgykfaur

Y{mkr ykxy iakx oay xcav xbfobdbhgoy ibddkukohkx bo yck yaeghha xlamk cgebyvbyc yck kshj{xbao ad yck ;7 ~jgxybh jglbogyk vaumkux vcbhc kscbeby gxbfobdbhgoyjr cbfcku yaeghha xlamk cgeby ycgo yck haoyuaj fua{~/

Ycbx aexkutgybao hgo ek ~axxbejr gyyube{yki ya xahbajafbhgj ukgxaox* boibhgybof g

jgufku {xk ad yaeghha bo ej{k hajjgux #yck ;7 ~jgxybh jglbogyk vaumkux" ycgo vcbykhajjgux #yck ~gycajafbxyx goi haoyuajx"/

8/2/2019 Biological Monitoring of Exposure to Formaldehyde by Roberto Bono

14/19

Bo auiku ya xk~gugyk yck

haoyube{ybao ad yaeghhaxlamk bo yck daulgybao ad

O,lkycrjkotgjbok* yckxygybxybhgj gogjrxbx vgxuk~kgyki haoxbikubof aojryck 75> oao,xlamkux/

Ks~axki ya daulgjikcrik

Haoyuajxg

62f!l8

#jaf,yugoxd/"

^gycajafbxyx

78

^jgxybh jglbogykvaumkux

53

lkibgo 776/2 #5/>65" 5>3/; #5/593" 52/3 #7/969"

lkgo 784/7 #7/244" 77;/2 #>/548" 9>/9 #7/;>5"

GOATG ~ : >/>>>7/ Y{mkr0 #78 tx 53" >/>5; , #78 tx 62": >/>>>7 , #53 tx 62" : >/>>>7 , #97 tx 62" y,ykxy : >/>>>7

Yck oao,xlamkux

g ukdkukohk hgykfaur

G fkokugj ibddkukohk bx hjkgujr ktbikoy #~ : >/>>>7" glaof yck ycukk jktkjx ad

ks~axbybao ya daulgjikcrik/

Y{mkr ykxy iklaoxyugykx g cbfcku ks~axbybao ya daulgjikcrik dau yck ~jgxybhjglbogyki vaumkux ycgo dau ~gycajafbxyx #~ < >/>5;" goi g cbfcku ks~axbybao bo yckyva ~uadkxxbaogjjr ks~axki fua{~x ycgo bo haoyuajx/

8/2/2019 Biological Monitoring of Exposure to Formaldehyde by Roberto Bono

15/19

Ks~axki ya daulgjikcrik

Haoyuajxg

62

O laj!f fjaebo

#jaf,yugoxd/"

^gycajafbxyx

78

^jgxybhjglbogykvaumkux

53

lkibgo 78>/7 #5/77" 895/5 #5/5;" ;7/; #7/67"

Lkgo 599/6 #5/73" 83>/4 #5/93" 788/4 #7/6"

GOATG ~ : >/>>>7/ Y{mkr0 #78 tx 53" O/X/ , #78 tx 62" />58 , #53 tx 62" : >/>>>7 , #97 tx 62" , y,ykxy : >/>>>7g ukdkukohk hgykfaur

Y{mkr ykxy xcavx oa ibddkukohk ekyvkko yck yva yr~kx ad ks~axbybao yadaulgjikcrik #78 tx53"* e{y xbfobdbhgoy ibddkukohkx vkuk ktbikohkiekyvkko kghc fua{~ ad ~uadkxxbaogjjr ks~axki ya daulgjikcrik goihaoyuaj fua{~ #78 tx62 goi 53 tx62"

Yck oao,xlamkux

G fkokugj ibddkukohkglaof yck ycukk jktkjxad ks~axbybao bx hjkgujr

ktbikoy gjxa dau O,lkycrjkotgjbok#~:>/>>>7" /

8/2/2019 Biological Monitoring of Exposure to Formaldehyde by Roberto Bono

16/19

Yck hauukx~aoibof O,lkycrjkotgjbok haohkoyugybaox guk uk~ukxkoyki er yckgtkugfk tgj{k goi eas,~jay dau kghc w{guybjk/ Yck ykxy ~uatbikx cbfc xygybxybhgj

xbfobdbhgohk #~ : >/>>>7" iklaoxyugybof ibukhy ukx~aoxbebjbyr ad daulgjikcrikks~axbybao bo yck O,lkycrjkotgjbok daulgybao/ Bo ~guybh{jgu* yck ukx~aoxk ad ycbx

ebalgumku gx g d{ohybao ad daulgjikcrik bx jbokgu gy jav jktkjx

Bo auiku ya gxxkxx yck

xkoxbybtbyr ad yck O,lkycrjkotgjbok lgumku bo

ukx~aoibof ya go bohukgxkiks~axbybao ya daulgjikcrik*

boik~koikoyjr dual yck~uadkxxbao ad yck x{e`khyx* gGOATG ykxy vgx hguubki a{y eribtbibof gjj yck 768 x{e`khyx

boya da{u w{guybjkx ghhauibof yayck lkgx{uki daulgjikcrik/

;/8 5;/; 5;/4 49/6 44/> 7;3/3 7;2/5 ;;3/9

BT w{guybjk BBB w{guybjk BB w{guybjk B w{guybjk

#f!l8"Aok,vgr GOATG ~ : >/>>>7

8/2/2019 Biological Monitoring of Exposure to Formaldehyde by Roberto Bono

17/19

9/ Yckxk ~uktkoybtkghybaox g~~kgu okhkxxgur*ekhg{xk yck ebajafbhgjkddkhy ad cklafjaebogjmrjgybao bx hjkgujr ktbikoy

ktko gy l{hc javkudaulgjikcrikhaohkoyugybaox ycgo yckghy{gj x{ffkxyki jblby

7/ Ikx~byk yck uklgumgejk ibddkukohkxbo yck 5 ~uadkxxbaox* vk iklaoxyugykiycgy yck ebajafbhgj kddkhyx addaulgjikcrik guk hjkgujr ktbikoygoi hal~gugejk* oa lgyyku vcgy guk

yck haoibybaox {oiku vcbhc ycbx~uadkxxbaogj ks~ax{uk ahh{uuki/

5/ Ycukk x{e`khyx vkuk ks~axki yacbfcku haohkoyugybaox ycgo yck jblbyx{ffkxyki #>/86> lf!l8 "

By hgo gxx{lk ycgy yckxk kshkkiboftgj{kx lgr ek ~axxbejr i{k ya bxajgyki

k~bxaikx ad bl~ua~ku ekcgtbau auykl~augur caaix lgjd{ohybao/

8/ Vcbjk jkxx cgpguia{x x{exygohkx guk ks~khykiya uk~jghk daulgjikcrik* by l{xy ek uki{hki boeayc ahh{~gybaogj kotbuaolkoyx ycua{fcekyyku gx~bugybao ad kscg{xyx goikotbuaolkoygj tkoybjgybao/

^guybh{jgujr* bo g ~gycajafbhgj vguix yck~uktkoybao g~~kgux kgxbku* er eaycuki{hbof yck w{goybyr ad daulgjikcrik

gia~yki dau uki{hybao goi yukgybof {oikutgh{{l yck gogyalbhgj ybxx{kx uklatki er

yck ~gybkoyx bo yck a~kugybof uaal/

Ibxh{xxbao 7!8

8/2/2019 Biological Monitoring of Exposure to Formaldehyde by Roberto Bono

18/19

Ibxh{xxbao 5!8

5/ haybobok ktbikohki g xbfobdbhgoycbfcku ks~axbybao ya yaeghha xlamk bo

yck ~uadkxxbaogjjr ks~axki yadaulgjikcrik/ Ycbx gx~khy* ktko bd

g~~gukoyjr ~gugjjkjx yck ~ukxkohk addaulgjikcrik bo yaeghha xlamk* iakxoay xkkl ya ek i{k ya gexau~ybao ad

yck fgx er ycbx ua{yk e{y ya ayckuukgxaox/

7/ Yck iklaoxyugyki ibddkukohkxad O,lkycrjkotgjbok cgtk ya ek

gyyube{yki ya yck ibddkukoy O,lkycrjkotgjbok daulgybao* oay ya

ibddkukoy eghmfua{oi jktkjx ad O,lkycrjtgjbok/

8/ G xbfobdbhgoy cbfckuhaohkoyugybaox ad haybobok bovaumkux ad ~jgxybh jglbogykx bx

~uaegejr ik~koikoy er yckbuxlambof cgebyx* jgufku gx o{leku

ad xlamkux goi gx hbfgukyykx!igr*yr~bhgj ad yck ej{k hajjgux* ycgo bohaoyuajx/

9/ Ktko er kshj{ibof yck xlamkuxdual yck ktgj{gybao* igyg uk~auyki

xybjj xcav g xbfobdbhgoyjr cbfckuhaohkoyugybao ad O,lkycrjkotgjbokdau eayc ~gycajafbxyx goi ~jgxybh

jglbogyk vaumkux vbyc ukx~khy yayck haoyuajx/

8/2/2019 Biological Monitoring of Exposure to Formaldehyde by Roberto Bono

19/19

Xalk hubybhgj dghyaux hgo ek ktbikohki er haoxbikubof0

g" yck ks~axbybao tgubgebjbyr*

e" yck ibddkukoy yblk ikxhubeki er yck yva lkgx{uklkoyx* oglkjr 6 c dau

daulgjikcrik goi 75> igrx dau O,lkycrjkotgjbok* yck jbdk ad yck

kurycuahrykx* goi

h" yck O,lkycrjkotgjbok tgubgebjbyr #~axxbejk fkokybh ~ajrlau~cbxlx"/

Ibxh{xxbao 8!8