Post on 17-Jul-2021
TNF
TNFR1
IL-1
IL-1RLPS
TRADD FADD TRAF2 TRAF3
NEMO
IKKα
IKBαp65
IKKβ
NEMO
IKKα IKKβ
myD88IRAK1/4 Tyr Kinase
Calpain
IRAK CK2
NIKTAB TAK
TRAF6
TRAF6
S32 S36
p50
IKBαp65
IKBαdegradation
Y42
S866
S870
p50
IKBαp65p50
Canonical PathwayIKK Independant
Pathway
HypoxiaH2O2 UV, Her2
CD40L
CD40
Non-canonicalPathway
IKBαdegradationub
p65p50
RELBp100
RELBp52
RELBp52
Proteosomaldegradation
Coactivator
p65p50 AC
TranscriptionalActivation
p65p50 TF
Promoter-targetingRegulation
Distinct Binding Sites
Corepressor
p65p50
TranscriptionalRepression
ub
ub
◣ Cytokines / Chemokines◣ Immunoreceptor◣ Cell adhesion molecules◣ Acute phase proteins◣ Stress response
◣ Cell surface receptors◣ Regulators of apoptosis◣ Growth factors and ligands◣ Early response genes◣ Transcription factors & regulators
◣ Lymphoid organogenesis◣ B cell maturation◣ Humoral immunity
Nuclear factor kappa B (NFkB) is a protein complex that controls large number of genes responsible for the regulation of apoptosis, inflammation, tumorigenesis and a variety of immune responses. NF-kB is sensitive and responsive to stimuli such as cytokines, stress, UV, low oxygen, bacterial or viral infections.
Antibody˙Duo˙ELISA Kit
NFkB Pathway
ub
c-IAP1/2
www.arigobio.com
NFkB Signaling Pathway Related ProductsProduct NameCatalog No. Clonality Applications Reactivity
ARG51780IKK beta pY199
Rel or NF-kappaB (NF-kB) proteins comprise a family of structurally-related eukaryotic transcription factors that are involved in the control of a large number of normal cellular and organismal processes, such as immune and inflammatory responses, developmental processes, cellular growth, and apoptosis.Up-regulation of phospho-IKK, phospho-p38, phospho-JNK and down-regulation of IKB alpha is often associated with the activation of NF-kB downstream signaling pathway.
Product Description:
E
E
E
E
E
E
E
E
ARG51780
ARG54059
ARG51850
ARG51807
ARG51651
IKK beta pY199
IkB alpha antibody (N-term)
p38 MAPK pT180/Y182
JNK1/2/3 pT183/Y185
IKB alpha pS32/36
Rabbit pAB
Mouse mAB
Rabbit pAB
Rabbit pAB
Rabbit pAB
ICC/IF
WB
WB
WB, ICC/IF
WB, IHC, ICC/IF
H,M,R
H,M
H,M,R
H,M,R
H,M,R
50 µl
50 µl
50 µl
50 µl
50 µl
Component Name
Component cat no. Clonality Applications Reactivity Package
ARG51160IKB alpha antibody
ARG51651IKB alpha pS32 / 36 antibody
ARG51651
ARG54059
IKB alpha pS32/36
IkB alpha antibody (N-term)
Rabbit pAB
Mouse mAB
WB, IHC, ICC/IF
WB
H,M,R
H,M
50 µl
50 µl
ARG54369
ARG20070
ARG80154
ARG20066
ARG52619
ARG52770
ARG80130
ARG54127
ARG51660
ARG54686
ARG20319
ARG80237
ARG80204
ARG80504
ARG80712
ARG80196
ARG80503
ARG54631
ARG54348
ARG51015
ARG51519
ARG51520
ARG51017
ARG51276
ARG65677
ARG51514
ARG51516
ARG51664
BAFF antibody
BAFF antibody
BAFF ELISA Kit
Calpain1 antibody
Calpain1 antibody
CD40 antibody
CD40L ELISA Kit
FADD antibody
IKappaB alpha pY42 antibody
IKK beta antibody
IL-1a antibody
IL-1a ELISA Kit
IL-1a ELISA Kit
IL-1a ELISA Kit
IL-1b ELISA Kit
IL-1b ELISA Kit
IL-1b ELISA Kit
IRAK4 antibody
MYD88 antibody
NFkB p100/p52 antibody
NFkB p100/p52 pS866 antibody
NFkB p100/p52 pS870 antibody
NFkB p105 antibody
NFkB p105 antibody
NFkB p65 antibody
NFkB p65 pT254 antibody
NFkB p65 pT435 antibody
NFkB p65 pT505 antibody
WB, ICC/IF
WB
ELISA
WB
WB, IHC
IHC
ELISA
WB
WB, IHC
ELISA, ICC/IF, WB
WB, Neut
ELISA
ELISA
ELISA
ELISA
ELISA
ELISA
WB, ICC/IF
WB
WB, IHC
WB, IHC, ICC/IF
WB, IHC, ICC/IF
WB, IHC
WB, ICC/IF
IHC, WB
WB, IHC, ICC/IF
WB, IHC, ICC/IF
WB, IHC
Rabbit pAB
Rabbit pAB
Rabbit pAB
Rabbit mAB
Rabbit pAB
Mouse mAB
Rabbit pAB
Rabbit pAB
Rabbit pAB
Rabbit pAB
Rabbit pAB
Rabbit pAB
Rabbit pAB
Rabbit pAB
Rabbit pAB
Rabbit pAB
Mouse mAB
Rabbit pAB
Rabbit pAB
Rabbit pAB
H
H
H
H, M, R, Bo, P, Rb
H
H
H
H
H, M, R
H
H
R
M
H
R
M
H
H
H, M, R
H, M, R
H, M, R
H, M, R
H
H, M, R
H, M
H, M, R
H, M, R
H, M, R
ARG51807JNK 1 / 2 / 3
(pT183 / Y185)
ARG51850P38 MAPK
(pT180 / Y182)
Component Name
Component cat no. Clonality Applications Reactivity Package
Hayden and Ghosh. (2012) Genes and Dev 26: 203-234Baeuerle and Henkel. (1994) Ann Rev Immunol 12: 141-179
HeLa cells
Human breastcarcinoma tissue
NF-kB Activation Antibody Panel (ARG30205)
Phospho-IKB alpha Antibody Duo (Total, pS32/36) (ARG30037)
ARG65351Goat anti-Rabbit IgG Antibody (HRP)
D
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with RELA (p65). Four transcript variants encoding different isoforms have been found for RELA. (provided by RefSeq, Sep 2011)NFkB (p65) has multiple phosphorylation site with different regulations and functions. Phosphorylation at Serine 536 is mediated by IKK beta and/or IKK alpha in the cytoplasm and it is required for p65 activation. Phosphorylation on Ser276 of p65 in the nucleus enhances its ability to recruit histone acetyltransferases such as cAMP response element-binding (CREB)-binding protein (CBP) and p300 and to displace p50–histone deacetylase (HDAC)-1 complexes from DNA. In addition, IL1 beta and TNF alpha stimulate p65 phosphorylated at Ser529 through CK2 protein.ARG30029, ARG30030 and ARG30031 NFkB phosphor Duos include antibodies react total p65 protein and p65 phosphorylated at Ser276 or Ser529 or Ser536. It is useful for the user in p65 related functional studies.
NFkB Target GenesProduct NameCatalog No. Clonality Applications Reactivity
Product NameCatalog No. Clonality Applications Reactivity
NIK antibody
RelB pS573 antibody
TAB1 antibody
TAK1 antibody
TNF-alpha antibody
TNF-alpha ELISA Kit
TNF-alpha ELISA Kit
TNF-alpha ELISA Kit
TNFR1 antibody
TRADD antibody
TRAF2 antibody
TRAF3 antibody
Rabbit pAB
Rabbit pAB
Mouse mAB
Goat pAB
Mouse mAB
Mouse mAB
Rabbit pAB
Goat pAB
Rabbit pAB
WB, ELISA
WB, IHC
WB
WB
FACS, IHC, ICC/IF, FuncSt
ELISA
ELISA
ELISA
FACS, IP, IHC, FuncSt
IHC
WB, IHC
WB
H
H, M
H
H
H, Pri, P
R
M
H
H
H
H
H, M, R
E
E
E
E
ARG54322
ARG51741
ARG54074
ARG63986
ARG65482
ARG80241
ARG80206
ARG80120
ARG65452
ARG53680
ARG64172
ARG20163
Bax antibody
Bcl-2 antibody
Bcl-xL antibody
BDNF antibody
Bim antibody
Bmi1 antibody
BMP-2 ELISA Kit
Rabbit pAB
Rabbit pAB
Rabbit pAB
Rabbit pAB
Rabbit pAB
Mouse mAB
ELISA, IHC-P, WB
WB, IHC, IP
WB
WB
WB, ICC/IF
WB
ELISA
H, M, R
H, M, R
H, M, R
H
H
H
H
ARG65612
ARG20424
ARG51057
ARG20307
ARG54406
ARG53981
ARG80164
D
D
D
ARG51518
ARG51708
Rabbit pAb
Rabbit pAb
WB, IHC-P, ICC/IF
WB, IHC-P, ICC/IF
H,M,R
H,M,R
50 µl
50 µl
Component NameComponent
cat no. Clonality Applications Reactivity Package
ARG30029Phospho-NFkB Antibody Duo (pS529, pS536)
NFkB-p65 pS536 antibody
NFkB-p65 pS529 antibody
ARG51013
ARG51518
Rabbit pAb
Rabbit pAb
WB, IHC-P
ICC/IF, IHC-P, WB
H,M,R
H,M,R
50 µl
50 µl
Component NameComponent
cat no. Clonality Applications Reactivity Package
ARG30248Phospho-NFkB Antibody Duo (Total, pS536)
NFkB p65 antibody
NFkB p65 pSer536 antibody
ARG51708NFkB-p65 p-Ser529 antibody
Human breastcarcinoma tissue
ARG51518NFkB-p65 p-Ser536 antibody
HeLa cells
ARG51013NFkB p65 antibody
Human breastcarcinoma tissue
Phospho-NFkB p65 Antibody Duo
ARG65048PRDM-1 antibody
Human tonsil Sw480 cells HeLa cellsHuman colon
adenocarcinoma
ARG53981Bmi1 antibody
ARG54038ICAM1 antibody
ARG52901COX-2 antibody
ARG20345MIP-1a antibody
ARG51081p53 antibody
NFkB Target GenesProduct NameCatalog No. Clonality Applications Reactivity
E
E
E
E
E
E
E
E
E
E
ARG55523
ARG51034
ARG52902
ARG80195
ARG80825
ARG53974
ARG63244
ARG80143
ARG80229
ARG80185
ARG54038
ARG80116
ARG80493
ARG53370
ARG53340
ARG80908
ARG20345
ARG80174
ARG52352
ARG62568
ARG62512
ARG10519
ARG65048
ARG20190
ARG65593
ARG20161
ARG80120
ARG80134
BMP-4 antibody
c-MYC antibody
COX2 antibody
CRP ELISA Kit
EPO ELISA Kit
Fibronectin antibody
GATA3 antibody
G-CSF ELISA Kit
GM-CSF ELISA Kit
GRO beta / CXCL2 ELISA Kit
ICAM-1 antibody
IFN-gamma (HS) ELISA Kit
IGFBP-2 ELISA Kit
iNOS antibody
IRF4 antibody
MIP-1 alpha ELISA kit
MIP-1a antibody
MIP2 ELISA kit
NDMAR1 antibody
NGF antibody
NRG1 antibody
p53 antibody [Pab1801]
PRDM1/BLIMP1 antibody
P-selectin antibody
STAT5A antibody
TLR9 antibody
TNF-alpha ELISA kit
VCAM1 ELISA kit
WB, IHC-P
WB, IHC
IHC
ELISA
ELISA
IHC
WB, IHC
ELISA
ELISA
ELISA
WB
ELISA
ELISA
IHC
WB, IHC
ELISA
WB, IP
ELISA
WB, IP
ICC/IF, FACS, IHC
WB, IP, IHC
ChIP, ELISA, FACS, ICC/IF, IHC, IP, RIA, WB
WB, IHC
WB, IHC
WB, IHC
WB
ELISA
ELISA
Rabbit pAB
Rabbit pAB
Rabbit mAB
Rabbit pAB
Goat pAB
Mouse mAB
Rabbit pAB
Rabbit mAB
Rabbit pAB
Mouse mAB
Mouse mAB
Mouse mAB
Mouse mAB
Goat pAB
Rabbit pAB
Rabbit pAB
Rabbit pAB
H, M
H, M, R
H, M, R
H
H
H
H
H
M
H
H
H
H
H, M, R
H
R
M, R
H
M, R
H, R, Rb, Cat, Fer, Pri
H, M, R
H, M, R
H
H, M, R
H, M, R
H, M, R, P
H
H
ELISA Kits Duo/Panel also available Species Reactivity: H- Human; M- Mouse; R- Rat; Rb- Rabbit; Pri- Primate; P- Pig; Mk- Monkey; Bo- BovineE D
No.22, Ln. 227, Gongyuan Road., Hsinchu City 300, TaiwanE : info@arigobio.com / T : +886 (3) 5621738 / F : +886 (3) 561 3008
www.arigobio.com
D
D
D
E