Pathophysiology of

Anaphylaxis Dr Hettiarachchi

Consultant AnaesthetistSBSCH- Peradeniya

IgE

Histamine

Leukotrienes

Prostaglandins

Diagnosis

Not always obvious

Sudden

Onset and

Rapid

Progression

1.

Life-threatening

A B C2.

Skin and/or

Mucosal Changes

3.

alone

are not a sign

Skin and/or

Mucosal Changes

Gastrointestinal symptoms

Increased respiratory

rate

Pale, Clammy skin

DIFFERENTIAL DIAGNOSIS

Life threatening conditions

Non-Life-threatening conditions

DIFFERENTIAL DIAGNOSIS