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A Perspective
onMinerals & Metals
inHuman Health
Bradford S. Weeks, M.D.
www.weeksmd.com
md@weeksmd.com
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Dedication:
Richard Kunin
&
Paracelsus
Alterius non sit qui suus esse potest~
Let no man that can belong to himself be of another
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Everything fails meevery thing
These instruments, do they not all
Mock me? Lathe, cylinder, and ring,
And cog and wheelin vain I call
On you for aid, ye keys of Science,
I stand before the guarded doorOf Nature; but it bids defiance
To latch or ward: in vain I prove
Your powers, the strong bolts will not move.
Faust, in his study, before the deal
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Mysterious, in the blaze of day,
Nature pursues her tranquil way:
The veil she wears, if hand profane
Should seek to raise, it seeks in vain,
Though from her spirit thine receives,
When hushed it listens and believes,Secretsrevealed, else vainly sought,
Her free gift when man questions not,__
Think not with levers or with screwsTo wring them out if she refuse.
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Definitions
Element - a type of atom that is distinguished by its
atomic number (the number of protons in its nucleus).The term is also used to refer to a pure chemicalsubstance composed of atoms with the same number ofprotons.
Mineral - a naturally occurring homogenous substancewith a crystalline structure and defined chemicalcomposition formed as a result of geological process.
Metala lattice of positive ions surrounded by a cloud of
delocalized electrons. They are one of the three groupsof elements as distinguished by their ionization andbonding properties, along with the metalloids andnonmetals. They rarely found in pure form in nature
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Lithium #3 in the periodic table = 3 protons
- lightest metal,- highest specific heat of any solid metal so
used in heat transfer technology
relieves hotheadedness mania
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Element A # Qualities
Lithium 3 Lightest metal, a dense as water, highest specific
heat, transfer use
Beryllium 4 Toxic, used in nuclear reactors, low thermal neutron
absorption
Boron 5 Natural fiber optic and transmits infrared light
Carbon 6 Hexagonal crystal, obtained from buring with
insufficient oxygen; Derives only from life forms
Nitrogen 7 78% of air, carrier of astrality, universes 5th most
abundant element; allergen yet inert as gas, cryo L
Oxygen 8 Oxy genes (GR acid forming), fire air 1/2 earth
crust, 2/3 of you 9/10th of water , 3rd in Universe;
Fluoride 9 Most electronegative and reactive of all elements; used
in producing uranium, waste to water supply
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Element A # Qualities
Hydrogen 1 Gr Hydro genes= water forming most
abundant element in universe; star fuel; saturates C
Lithium 3 Lightest metal, a dense as water, highest specific
heat, transfer use
Sodium 11 Med Latin sodanum headache remedy, ignites on
contact with water; burns yellow
Potassium 19 KCL fertilizer, KOH soap K nitrate, flash on matches
Rubidium 37 Byproduct of refining lithium, spectroscope deep red;
liquid at room temp, ignites H and O, blend w Hg Au
Cesium 55 Spectroscope blue (L caesius = blue sky), melting pt83 deg F in your hand, beer brewing, (watch K)
Francium 87 Last naturally occurring element discovered, 30 g on
earth at one time; radioactive; (Astatine is rarest)
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Irridium 77 - 2nd densest element, least corrosive,
siderophilic, meteorites, dinosaur extinction;
Platinum 78 - alchemical symbol joined Ag and Au
catalytic converters, missile cones, chemo Rx
Gold 79most malleable: 1 oz -> 5 meters sq; 400x
thinner than a human hair = 0.000127mm
Mercury 80 - one of 6 elements liquid at room temp and
the only metal,
Titanium 81 - 9th most common earth element, stronger
and lighter than steel, non-corrosive with salt water, human
tissue, only element than burns in pure nitrogen;
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Egyptian
signs
for theElements
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Alchemical and chemical
symbols in
Nicolas de Locques
Les rudimens de laphilosophie naturelle,
Paris 1655.
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Elements
1. Oxygen.
2. Hydrogen.
3. Nitrogen.4. Carbon.
5. Sulphur.
6. Phosphorus
7. Gold.
8. Platinum.9. Silver.
Chemical Symbols used by Dalton 19th century
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10. Mercury.
11. Copper.12. Iron.
13. Nickel.
14. Tin.
15. Lead.16. Zinc.
17. Bismuth.
18. Antimony.
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Compounds.
37. Water.
38. Hydrofluoric acid.
39. Hydrochloric acid.40. Chloric acid.
41. Nitric oxide.
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Alum
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Woodcut from William Cuningham
The cosmographical glasse, 1559
Frontpiece Woodcut of the celestial
sphere by Erhard Schn, 1515.
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Definitions cont.It is far easier to define something
than it is to know it.
When we name something we demystify it
and have dominion over it.
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Which box are you thinking outside of?
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Knowing and Thinking
In medicine,
you need to know nothingbut you need to be able to think.
Otto Wolff, M.D.
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Engraving from Baro Urbigerus
Besondere chymische Schrifften, 1705.Frontispiece engraving from 1774
Drey curieuse chymische tracttlein
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Many have said of alchemy,
that it is for the making of
gold and silver.
For me such is not the aim,but to consider only what
virtue and power
may lie in medicines.
Paracelsus
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Year Date Alchemist Metal Place
1382 Apr 25 5pm N.Flamel Hg Paris
1586 Dec 19 NS Kelly Hg Bohemia
1602 Mar 13 4pm NS A.Seton Pb Amsterdam1648 Jan 15 Richthausen Hg Prague
1667 Jan 19 10am Helvetius Pb The Hague
1701 Oct 1 8pm Bttger Ag Germany
1709 Feb 16 eve Lascaris Hg Germany
1716 Dec 31 Pb Rhineland
1782 May 25 J. Price Hg Guildford
Golden Moments
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Metals are condensed vapors from the
various planets which were trappedwhen earth solidified from a gaseous
state to its solid state. When you hold a
metal in your hand, you are holding theforces of its planet also.
paraphrase Rudolf SteinerOccult Science
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Metallic Presence in Humans
Element Decimal Potency
Mg, Fe, Al, Zn D1-D2
Cu, Mn D2-D3
As, Ti, V, Cr, Ni, St, Li D3-D4
Ag, Co, Rb, Sn, Mo D4D5
Ag, U D5-D6
U in bones D6
Ra D11
D1 = 10 to the -1
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Sunday Dimanch Sun
Monday Lundi Moon
Tuesday Mardi Mars
Wednesday Mercredi Mercury
Thursday Jeudi Jupiter
Friday Vendredi Venus
Saturday Samedi Saturn
Weekdays (French) Planet
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Monday's child is fair of face.Tuesday's child is full of grace.
Wednesday's child is full of woe.
Thursday's child has far to go.Friday's child is loving and giving.
Saturday's child works hard for a living,
But the child who is born on the Sabbath DayIs bonny and blithe and good and gay.
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Sunday good and gay Sun
Monday fair of face Moon
Tuesday full of grace Mars
Wednesday full of woe Mercury
Thursday far to go Jupiter
Friday loving and giving Venus
Saturday hard for a living Saturn
Weekdays Child Planet
Fortune telling rhymes of this type circulating in England in the 1570s
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Electrical Conductivity of Metals
Iodine 8.0E-16 10 6th /cm
Sulfur 5.0E-24 10 6th /cm
Mercury 0.0104 10 6th /cm
Uranium 0.038 10 6th /cm
Lead 0.0481 10 6th /cm
Tin 0.0917 10 6th /cm
Iron 0.0993 10 6th /cm
Gold 0.452 10 6th
/cmCopper 0.596 10 6th /cm
Silver 0.63 10 6th /cm
Least
More
Most
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Upon this age that never speaks its mind,
This furtive age, this age endowed with power
To wake the moon with footsteps, fit an oar
Into the rowlocks of the wind, and find
What swims before his prow, what swirls behind---
Upon this gifted age in its dark hour,Rains from the sky a meteoric shower
Of facts . . . they lie unquestioned, uncombined.
Wisdom enough to leech us of our ill
Is daily spun; but there exists no loomTo weave it into fabric. . .
"Huntsman, What Quarry?" by Edna St. Vincent Millay
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The essence of a living
organism lies not in itssubstance, but in its action.
The organization is not asystem of substances, it is
activity.
Dr. Rudolf Steiner and Ita Wegman, M.D.
Fundamental of Therapy
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Lilly Kolisko
http://www.science.a
nth.org.uk/kolisko/
http://www.science.a
nth.org.uk/kolisko/K
olisko_211126.htm
http://www.science.anth.org.uk/kolisko/K
olisko_290627.htm
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Further Reading
1966 The Nature of Substance - Rudolf Hauschka, trans.
from German.
1973 The Secrets of Metals - Wilhelm Pelikan,
Anthroposophic Press, trans. from German.
1918 Fundamental of Therapy - Dr. Rudolf Steiner and Ita
Wegman, M.D.
1921 Spiritual Science and Medicine - Rudolph Steiner
1537 The Book Concerning the Tincture of the
Philosophers - Paracelsus
1531 The Aurora of the Philosophers - Paracelsus
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Gold substance
Sun forces
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Gold for ArthritisJacques Forestier (1890 - 1978) was a French internist who
was a pioneer in the field of rheumatology. He studied and
practiced medicine in Paris, and was founder of the
National French Society of Rheumatology. Jacques
Forestier is remembered for his introduction of gold salts as
a remedy for rheumatoid arthritis. Today, injectable gold
salts such as gold sodium thiomalate and aurothioglucose
are considered by many to be the most effective treatment
for arthritic ailments.
(His son, 3rd generation rheumatologist, uses honey bee venomto treat arthritis)
Gold isotope 198 is a chemotherapy agent;
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Pro-apoptotic effect of aurothiomalate in prostate cancer cells.
Trani M , Sorrentino A , Busch C Landstrm M
Ludwig Institute for Cancer Research, Uppsala University, Uppsala, Sweden.
It has been recently demonstrated that small gold compounds could have a
potential anti-tumoral activity.
Here, we report that aurothiomalate (ATM), a gold compound already used in
clinical therapy for the treatment of rheumatoid arthritis, has a pro-apoptotic
effect in aggressive prostate cancer (PC3U) cells.
Moreover we could link ATM treatment to activation of the mitochondrial or so
called intrinsic pathway, as we observed release of cytochrome c from
mitochondria to cytoplasm, suggesting that the mitochondrial pathway is
involved in the pro-apoptotic effect mediated by ATM.
Taken together our data suggest that ATM could be a new promising drug for
the treatment of advanced prostate cancer.
Cell Cycle. 2009 Jan 15;8(2):306-13. Epub 2009 Jan 10.
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Copper substance
Venus forces
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- Copper (Cu) shifts attitude between the cuprous
(Cu1+) and cupric (Cu2+) forms, (usually cupric in
vivo) in order to easily receive and donate electronsin perpetual oxidation-reduction (redox) reactions
and also in order to serve as the anti-oxidant
function of scavenging free radicals.
- Prevents the peroxidation of PUFA maintaining
cell membrane integrity.
- Maintains myelin sheath via synthesis of
phospholipids.
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Copper prepares the Bed for Iron
Rudolf Steiner
1) Two copper-containing enzymes,
ceruloplasmin (ferroxidase I and II) oxidize
ferrous iron (Fe2+) to ferric iron (Fe3+),
allowing protein transferrin for transport iron
to the site of red blood cell formation.
2) Iron mobilization from storage sites is
impaired in copper deficiency
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Anemia is a clinical sign not only of iron
deficiency but of too little copper also.
Ceruloplasmin is required for iron transportto the bone marrow for synthesis of RBC.
High levels of dietary zinc increases thesynthesis metallothionein, which binds certain
metals at the intestinal villi and prevents their
absorption.
Metallothionein binds copper stronger than
zinc, so high levels zinc cause a decrease in the
absorption and bioavailability of copper.
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Copper-dependent enzyme actions (cuproenzymes)
Cytochromec oxidase catalyzes the reduction of
molecular oxygen (O2) to water (H2O), thereby
creating an electrical gradient used by the
mitochondria to produce ATP.
Cytochrome c oxidase activity regulates generation
and resilience of myelin sheath
Lysyl oxidase, is required for the cross-linking ofcollagen and elastin (support for the integrity of
connective tissue in coronary artery system)
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Copper-dependent enzyme actions (cuproenzymes) cont.
Dopamine-b-mono-oxygenase catalyzing dopamine -> NE
Monoamine oxidase (MAO) regulate norepinephrine,
epinephrine, and dopamine.
MAO also functions in the degradation of theneurotransmitter serotonin
Tyrosinase (a cuproenzyme) regulates melanin synthesis
Highest concentration of copper in brain and liver.
Copper deficiency is quite rare in humans.
Copper dependent enzyme actions (cuproenzymes) cont
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Copper-dependent enzyme actions (cuproenzymes) cont.
Superoxide dismutase (SOD) serves as an antioxidant by
catalyzing superoxide radicals to hydrogen peroxide which is
easily reduced to water.1) Intracellular copper/zinc SOD is found within most cells of
the body (RBC)
2) extracellular SOD is a copper-containing enzyme (in lungs
and plasma).
Ceruloplasmin seves as an antioxidant by binding copper, and
via its ferroxidase activity facilitates iron joining it transport
protein, transferrin, thereby mopping up Fe2+
Copper levels alter the synthesis of gene proteins which
regulated by copper-dependent transcription factors
(copper/zinc superoxide dismutase (Cu/Zn SOD), catalase
(think HDVit C and cancer)
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Mercury substance
Mercury forces
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Chinese emperor Qin Shi Huang Di buried in tomb with a
model of the land he ruled complete with rivers of mercurydied from drinking mercury and jade designed to give him
eternal life;
Ancient Greeks used mercury ointments
Romans use mercury cosmetics
Indian word for alchemy translates as the way of
mercury
Paracelsus
Mercury is harmless in insoluble form (mercuric sulfide)
but toxic in mercuric chloride and methyl/ethyl mercury;
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Lewis and Clark expedition:
Penis syringe was used to inject mercury solutions directly into the
urethra to treat venereal disease symptoms
Also used was oral elemental mercury and mercury salves.
Paracelsus: first documented use of a metal as medicine, mercury.
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Silver substance
Moon forces
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Palolo WormThis worm dances to thelight of the moon.
Spawning follows the lunar
cycle, around the seventhnight after the full moon
that follows the autumnal
equinox.
If it's a weak showing, then
a second rising can be
expected in November.
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Clinicial Indications for Silver
- regeneration,
- anti-biotic,- tissue detoxification
- see Gary Gordons FACT website:http://promed.gordonresearch.com/factfor
um/welcome.html topic silver
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IV Silver
250 cc bag colloidal silver 10ppm3cc of methylcobalamine and 50cc of
D50 glucose (to aid absorption)
Run at slow drip over 2 hrs
NOTE: IV silver for humans is not FDAapproved in USA despite the fact that silver
was Americas first IV antibiotic: 1860!
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December 20, 2007 the world press
published re Paul Karason, a California
man whose entire skin gradually turned
blue after consuming homemade
colloidal silver containing salt, waterand silver.
(Note: only silver chloride is toxic)
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Argyria: blue skin, eyes, nails.
Not dangerous, just unsightly
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Silicate
(with Oxygen)
substance
Earth forces
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Testosterone Estrogen
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Iron substance
Mars forces
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Oxygen transport and storage: Hemoglobin and
myoglobin are heme-containing proteins that store and
transport oxygen. Hemoglobin = 2/3 of total body iron
Electron transport and energy metabolism: Cytochromes
are heme-containing compounds involved in
mitochondrial electron transport and ATP production
Antioxidant and beneficial pro-oxidant functions:
Heme-containing enzymes catalase and peroxidase protect
cells against the accumulation of hydrogen peroxide,
Oxygen sensing (esp high altitudes or COPD):
compensate with RBC formation and angiogenesis
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Lead substance
Jupiter forces
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Lead and Light
Great refraction
Great dispersion
Radioactivity
Protection against diagnostic radiation
Lead has more more naturally occuring
isotopes than any other metal
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Lead
- Melts by candle flame 327 deg C.
- Vaporizes at temperature most metals
require to melt 1555 deg C.
- Expands and contracts faster and more
powerfully than other metals
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Just consider where the strongest forces of
decomposition are found in the earth, where
radium occurs;In lead the cosmos prepares a substance for
itself in which to concentrate the most
powerful splitting forces.By bringing lead into the human body you
place the body directly amid the process of
world degeneration; in lead we have aneffective means of evoking the forces of
decomposition. (Rudolf Steiner)
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Uranium and thorium, substances of the
highest density are starting points for
decomposition into other elements withthe accompanying transmutation of
matter into radiation, an imponderable,
leaving behind finally non-radioactivelead.
L d A th hi d
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Lead as an Anthroposophic remedy
(after Rudolf Steiner)
Lead mixed with honey and sugar for
arteriosclerosis
Lead subdues the hypertrophic forces of the
astral body that express themselves in craving. It
strengthens the forces of the ego organization and
produces an antipathy to alcohol.
Silver is an antidote to lead.
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Lead Toxicity
Neurological Symptoms
- Behavioral problems (erratic)
- Visual/Auditory dysfunction- Motor deficits (tremor)
- Cognitive deficits (dementia, depression),
Osteoporosis Int. 9 (1999)
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- Pb neurotoxicity typically manifests as a
disruption of Ca metabolism
- Lead keeps Ca channels open about 5X
longer than Ca and pollutes cells in that
manner.
Lead is a calcium antagonist
M h i f L d N t i it
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Mechanism of Lead Neurotoxicity
- Activates phosphokinase c (out competes calcium
binding creating erratic neuronalresponsiveness: impulsivity and restlessness
- Inhibits NMDA receptor function
- Disrupts synthesis of dopaminergic, cholinergic,and glutamatergic neurotransmitters
- Disrupts calcium homeostasis,
- Increases erratic and spontaneous NT release
- Disrupts microtubule metabolism
Ann Rev Pharmacol Toxicol(1995)35:391
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Tin substance
Saturn forces
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Cellular Attributes, Functions & Interactions:
Tin Synergists: Nickel, iodine, Vitamin B1, Vitamin C,
Tin Antagonists / Inhibitors: Iron, calcium, copper,
chloride, Vitamin B2, Vitamin E, [bismuth, zinc],
Low Levels / Deficiency - Symptoms and/or Risk Factors:Fatigue, depression, low cardiac output (left), low
adrenals, shortness of breath, asthma, headaches,
insomnia. - In animals, low tin results in poor growth,
alopecia / bilateral hair loss, hearing loss, andreduced feeding efficiency
source http://www.acu-cell.com/tin.html
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Tin in the human organism
- Highest in the thymus.
- Next in the tongue and salivary mucosa
- Then skin
- Then liver
- Then spleen
- Then brain
- Then heart
Tin concentration in the thymus glands of rats and mice and
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its relation to the involution of the gland.
Sherman LR, Masters J, Peterson R, Levine S
Tin is an ubiquitous element and thus enters mammals through the food
chain. It has never been found to be dysfunctional in either plants or
animal tissue and has been regarded as an innocuous background
material. Of the many organs and glands that have been analyzed for tin,
only the thymus gland exhibits an above average value.
The tin analysis of the muscle, spleen, and thymus indicated constant
values for the muscle and spleen tissue, but an increase in the thymic tin
concentration (ppm) with age. The increase indicates that the tin was
probably located in the medulla of the thymus, which may be theactive biochemical site for tin in rodents.
J Anal Toxicol1986 Jan-Feb;10(1):6-9
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Tin as a Remedy
to bring form to a disordered structure RS
regulates opposing fields of force RS
- Hydrocephalus- Tuberculosis and Pleurisy
- Liver congestion
- Eczema- Joint effusions - the tin cry when it is bent
- Immune function
Ti d th th l d i
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Tin and the thymus gland: a review.
Cardarelli N
Engineering and Science Technology U of Akron, OH 44325.
Experimental studies over the last decade have suggested an
association between thymus immune and homeostatic
function and exogenous tin. It has been hypothesized that
the thymus gland synthesizes and secretes one or more tin
bearing factors that enhance immune defenses against
malignancy and retard the gradual loss of immunecapacity with senescence.
Thymus 1990 Jun;15(4):223-31
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Tin Sources:
Tinned / canned foods,
cereal grains, dairy, meat,
vegetables, seaweed, licorice,
some toothpastes
Paracelsus Oath:
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Paracelsus Oath:
This is my Vow:
To perfect my medical art and never to swerve
from it so long as God grants me my office, and to
oppose all false medicines and teachings. Then to love
the sick, each and all of them, more than if my ownbody were at stake. Not to judge superficially, but by
symptoms, nor to administer any medicine without
understanding, nor to collect any money without
earning it. Not to trust any apothecary, nor to do anyviolence to any child. Not to guess, but to know.
Paracelsus 1493 - 1541
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Other Elements
(non-planetary)relevant to health
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Calcium
99% of our Calcium ~ 1 kg ~ is in bones
- Osteoporosis is initially a magnesium
disorder -> disrupted calcium deposition
(magnesium hardens teeth, not calcium)
- Take Cal and Mag @ 1:1 c D3 5000u/daysome say to not take together: antagonists
- See www.notmilk.com
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Zinc
- Clinical zinc deficiency humans first described in 1961,
"adolescent nutritional dwarfism" Middle East
- Zinc regulates growth and development, buttresses the
immune response, supports neurological function, andreproduction.
- > 100 different catalytic enzymes depend on zinc
- Zinc supports protein and cell membrane structure
- Zinc regulates gene expression functioning as transcription
factors as they bind to DNA
- Zinc is instrumental in cell signaling esp. re hormone
release and nerve impulse transmission and apoptosis
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Clinical Indications
- Skin
- Immune function
- Nerve sense
- Eyes
- Hearing- Regeneration of tissues
N
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Bradford S. Weeks, M.D. (c) 2009The worlds best deodorant~ think zinc!
New
From
Dr. Kunin
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Magnesium
Light bearer
Ignite a disc the size of sunhold up to thesun and magnesium burns as brightly
Stepping stone for light to become sugar
Where the imponderable gathers substance
Respiration for plantschlorophyll
Magnesium: Clinical Indications
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g
Rhymes with spasm (use it thusly)
Constipation
Headache
Uterine cramps
PreeclampsiaAngina
Claudication
Mitral ValveProlapse
Seizure
Prevention
Twitching (Chovsteks sign)
Fibromyalgia
Pre-chiropractic visit
AlcoholismInsomnia (relax muscles)
Anxiety (soma & psyche)
GERD, gastritisDental health (enamel)
High Cholesterol
Diabetes (metabolizes glucose)
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Iodine/Iodide
Clinical IndicationsRussian wisdom:
If the problem is internal, drink iodine,
If the problem is external, paint iodine.
Thyroid disorders
Cancer (enhances apoptosis)
ASCVDImmune function
Cystic processes
-Fibroids (labial swab with Lugols)
-Fibrocystic breast disease
Iodine Deficiency
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Iodine Deficiency- Most commonly preventable cause of mental retardation- Most common cause of endocrinopathy (goiter and primary
hypothyroidism).
- Neurological damage during fetal development as well as
during lactation.- The safety of therapeutic doses of iodine above the established
safe upper limit of 1 mg is evident in the lack of toxicity in
the Japanese population that consumes 25 times the median
intake of iodine consumption in the United States. (Japan'spopulation suffers no demonstrable increased incidence of
autoimmune thyroiditis or hypothyroidism)
- Klein-Levy Syndrome - myxedema coma (case report)
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&DbFrom=pubmed&Cmd=Link&LinkName=pubmed_pubmed&LinkReadableName=Related%20Articles&IdsFromResult=18645607&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract8/3/2019 A Perspective on Minerals and Metals in Human Health
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Iodine alters gene expression in the MCF7 breast cancer cell
line: evidence for an anti-estrogen effect of iodine.
Stoddard FR 2nd, Brooks AD, Eskin BA, Johannes GJ.
Department of Surgery, Drexel University College of Medicine, Philadelphia, PA
The protective effects of iodine on breast cancer have been postulated from
epidemiologic evidence . suggests that iodine may inhibit cancer promotionthrough modulation of the estrogen pathway. Quantitative RT-PCR confirmed the
array data demonstrating that iodine/iodide treatment increased the mRNA levels of
several genes involved in estrogen metabolism (CYP1A1, CYP1B1, and AKR1C1)
while decreasing the levels of the estrogen responsive genes TFF1 and WISP2. This
report presents the results of the first gene array profiling of the response of a breast
cancer cell line to iodine treatment. In addition to elucidating our understanding ofthe effects of iodine/iodide on breast cancer, this work suggests that iodine/iodide may
be useful as an adjuvant therapy in the pharmacologic manipulation of the estrogen
pathway in women with breast cancer.
Int J Med Sci. 2008 Jul 8;5(4):189-96.
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&DbFrom=pubmed&Cmd=Link&LinkName=pubmed_pubmed&LinkReadableName=Related%20Articles&IdsFromResult=18645607&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract8/3/2019 A Perspective on Minerals and Metals in Human Health
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Iodine and Breast CancerIodine: deficiency and therapeutic considerations.
Patrick L. Southwest College of Naturopathic Medicine, USA.lpatrick@frontier.net
Studies using 3.0- to 6.0-mg doses to effectively treatfibrocystic breast disease may reveal an important role foriodine in maintaining normal breast tissue architecture andfunction. Iodine may also have important antioxidantfunctions in breast tissue and other tissues that concentrate
iodine via the sodium iodide symporter.
Altern Med Rev. 2008 Jun;13(2):116-27
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Find
a cure
before I
grow
boobs!
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David Derry, M.D. & David Brownstein, M.D.
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Tin (Sn) is associated with Iodine (I) the same
way as calcium is associated with magnesium.
Tin supports the adrenals, iodine supports the
thyroid, both then affect cardiac output:
Tin + adrenals control the left side,
Iodine + thyroid control the right side.
http://www.acu-cell.com/sni.html
Food Serving Iodine (mcg)Salt (iodized) 1 gram 77
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( ) g
Cod 3 ounces* 99
Shrimp 3 ounces 35
Fish sticks 2 fish sticks 35Tuna, canned in oil 3 ounces (1/2 can) 17
Milk (cow's) 1 cup (8 fluid oz) 56
Egg, boiled 1 large 12
Navy beans, 1/2 cup 32Potato w peel 1 medium 60
Turkey breast, 3 ounces 34
Seaweed1/4 oz Variable; 4,500 mcg
A three-ounce serving of meat is about the size of a deck
of cards.
Turkey and potato were baked, navy beans cooked
Only Mae West believes
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Association of High Iodine Intake withthe T1799A BRAF Mutation in Papillary
Thyroid Cancer.
Guan H, Ji M, Bao R, Yu H, Wang Y, Hou P, Zhang Y,Shan Z, Teng W, Xing M.
J Clin Endocrinol Metab. 2009 Feb 3
y
Too much of a good thing is wonderful!
Be careful with excess iodine.
Iodine Drug interactions
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Amiodarone contains high levels of iodine and may
affect thyroid function.
Lithium in combination with SSKI ->
hypothyroidism.
SSKI -> less anticoagulant effect of warfarin
Acute Iodine ToxicityThis is rare (requires gram dosing)
Symptoms: burning of the mouth, throat, and stomach; fever;
nausea; vomiting; diarrhea; a weak pulse; and coma
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Selenium
glutathione peroxidase (anti-oxidant)
cytochrome P450 detoxification of xenobiotics;
Clinical indications:
cancer
viral infection
infertilityheavy metal detoxification
macular degeneration
Selenium
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Birth control for virus / viriE.W. Taylors theory that viruses encode for the selenoenzyme
glutathione peroxidase because they have a practicallyidentical enzyme - the net result being selenium deficiency forhumans and subsequent immunocompromised status.
See
Selenium and cellular immunity. Evidence that selenoproteins may beencoded in the +1 reading frame overlapping the human CD4, CD8, andHLA-DR genes. Taylor EW. Biol Trace Elem Res. 1995 Aug-Sep;49(2-3):85-95.
Functional studies of an HIV-1 encoded glutathione peroxidase Zhao L,Olubajo B, Taylor EW Biofactors. 2006;27(1-4):93-107
http://www.hdfoster.com/WhatReallyCausesAIDS.pdf By Harold Foster
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Lithium for Learning
Lithium: The Misunderstood Mineral Part 1
By Jonathan V. Wright, M.D.
(Reprinted From "Nutrition and Healing")
Think young into your 90s with this anti-aging
secret for your brain
Chronic lithium treatment magnifies learning in rats.
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Nocjar C, Hammonds MD, Shim SS. Dept Psychiatry, Louis Stokes Cleveland VA
Medical Center, Cleveland, OH 44141, USA. cxn18@cwru.edu
Recent electrophysiological work shows that chronic lithium
treatment increases long-term potentiation (LTP) in neurons
of the hippocampus, and LTP is thought to be the major
neurophysiological basis for the development of learning andmemory. This suggests that lithium might enhance learning
and memory. Thus chronic lithium treatment may improve
learning and memory in Alzheimer's disease, and do so not
only by blocking the formation of beta-amyloid and
neurofibrillary tangles as suggested by previous research, butalso by enhancing mechanisms involved in basal learning and
memory formation, such as hippocampal synaptic plasticity.
Neuroscience. 2007 Dec 19;150(4):774-88.
Lithium and cognitive enhancement: leave it or take it?
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Tsaltas E, Kontis D, Boulougouris V, Papadimitriou GN.
Experimental Psychology Laboratory, Department of
Psychiatry, Eginition Hospital, Athens, Greece,
tsaltasl@med.uoa.gr.
Lithium is established as an effective treatment of acutemania, bipolar and unipolar depression and as prophylaxis
against bipolar disorder. Accumulating evidence is
also delineating a neuroprotective and
neurotrophic role for lithium.
Psychopharmacology 2009 Jan;202(1-3):457-76.
N-methyl-D-aspartate receptors are involved in lithium-induced
state dependent learning in mice
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&DbFrom=pubmed&Cmd=Link&LinkName=pubmed_pubmed&LinkReadableName=Related%20Articles&IdsFromResult=18781296&ordinalpos=9&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract8/3/2019 A Perspective on Minerals and Metals in Human Health
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state-dependent learning in mice.
Rezayat M, Niasari H, Ahmadi S, Parsaei L, Zarrindast M.
Department of Pharmacology, School of Medicine, Tehran, Iran.
We have previously shown lithium-induced state-
dependent learning in a step-down inhibitory avoidance
task. The results suggest that NMDA receptors may be
involved, at least partly, in the lithium-induced state-
dependent learning.
J Psychopharmacol. 2009 Jan 22. [Epub ahead of print]
Lithium reduces ischemia-induced hippocampal
CA1 damage and behavioral deficits in gerbils
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&DbFrom=pubmed&Cmd=Link&LinkName=pubmed_pubmed&LinkReadableName=Related%20Articles&IdsFromResult=19164491&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstracthttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&DbFrom=pubmed&Cmd=Link&LinkName=pubmed_pubmed&LinkReadableName=Related%20Articles&IdsFromResult=19164491&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract8/3/2019 A Perspective on Minerals and Metals in Human Health
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CA1 damage and behavioral deficits in gerbils.
Bian Q, Shi T, Chuang DM, Qian Y.
Dept Anesthesiology, Nanjing Medical U, Nanjing, PR China.
This is believed to be the first report of lithium-induced
protection against hyperactivity in a novel open field andmemory impairment in a gerbil model of global ischemia.
These results underscore theability of lithium to improve
functional behavioral outcome in gerbil and rodent cerebral
ischemic models andfurther indicate the potential therapeutic
use of lithium in certain human stroke conditions.
Brain Res. 2007 Dec 12;1184:270-6
Cobalt Rx Vitamin B IM shots
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Cobalt Rx Vitamin B IM shots
Start with Folic Acid cc (precipitates)
then draw up Vitamin B12 ( or methylcobalamine) 1 cc
then draw up Vitamin B complex 1 cc,
and lastly Vitamin B6 (pyridoxine HCL) cc (= 3 cc total)
Take one shot as instructed with sterile procedure in upper outer buttock
(alternate sides) aim CHEEK to CHEEK.
Do this every AM for 30 days then we will reassess to determine any changes in
dosage and frequency.
Dispense: #4 vials, #30 3 cc syringes, 30 gauge needles, betadine Cansubstitute Folic acid with ACE 0.5 cc or Procaine 0.5 cc
or Glutathione 0.5 cc or Liver Extract 0.5 cc
Methylcobalamin used in peripheral neuropathy diabetic
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Methylcobalamin used in peripheral neuropathy, diabetic
neuropathy and disruptions of sleep-wake rhythms.
Cobalamins with folic acid enable DNA synthesis in cells
(in bone marrow and myeloid cells) and are essential co-
factors for two cellular reactions:
(1) the mitochondrial methylmalonyl coenzyme A mutase
conversion of methylmalonic acid (MMA) to succinate,
which links lipid and carbohydrate metabolism, and
(2) activation of methionine synthase, which is the rate
limiting step in the synthesis of methionine from
homocysteine and tetrahydrofolate
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Chromium
- metabolism of cholesterol and
glucose;
- assists with ASCVD, hypoglycemia,diabetes,
- GTF (niacin, glycine glutamic acid,
cysteine, and trivalent chromium)- hexavalent chromium is very toxic
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Manganese
Manganese is an essential mineral element
that is potentially toxic. The derivation of its
name from the Greek word for magicmagikos
remains appropriate because it plays an
important role in transmutation as a
constituent and an activator of many enzymes.
Food Serving Mn
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Pineapple, raw 1/2 cup, diced 0.91g
Pineapple juice
1/2 cup (4
ounces) 0.63
Pecans 1 ounce 1.28
Almonds 1 ounce 0.72
Peanuts 1 ounce 0.55Instant oatmeal (prepared with
water)1 packet 1.68
Raisin bran cereal 1 cup 1.88
Brown rice, cooked 1/2 cup 0.88Whole wheat bread 1 slice 0.60
In mg
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Manganese-activated enzymes
- critical in metabolism COH, bone, amino acids
Example of manganese containing enzymes:
1) Pyruvate carboxylase - gluconeogenesis
2) Phosphoenolpyruvate carboxykinase - gluconeogenesis
3) Arginase required by the liver for the urea cycle
(helps detoxifies ammonia)
4) Glycosyltransferases - synthesis of proteoglycans
(bone and cartilage)
5) Prolidase, prepares proline, for collagen formation6) Glycosaminoglycan synthesis
(manganese-activated glycosyltranserases) wound healing
Manganese and Wound
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Manganese and Wound
HealingShetlar MR, Shetlar CL. The role of
manganese in wound healing. In: Klimis-
Tavantzis DL, ed. Manganese in healthand disease. Boca Raton: CRC Press,
Inc.; 1994:145-157.
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Manganese superoxide dismutase
(MnSOD) is the principalantioxidant enzyme in the
mitochondria.
MnSOD catalyzes the conversion of
superoxide radicals to hydrogenperoxide, (itself reduced to water)
Manganese Deficiency
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g y
- impaired glucose tolerance - increased diabetes
- altered carbohydrate metabolism
- altered lipid metabolism
- bone demineralization and impaired growth
(note: blood calcium, phosphorus, and alkalinephosphatase levels were also elevated
suggesting increased bone remodeling
women with OP have lower serum MN levels
- decreased serum cholesterol levels- transient skin rash
- lowered seizure threshold
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Manganese - Clinical indications
- diabetes
- asthma
- fatigue
- allergies- osteoarthritis
- tendonitis
- manages metabolism of COH, proteins and fats- vital to thiamine metabolism, vitamin E utilization
and mucopolysacharide formation
Manganism Mn Toxicity: ~Parkinsons
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- Phase I
Psychiatric Abnormalities:
Hyperirritability, violence, compulsiveness, forced laughter,
apathy, sleep disturbance
- Phase II
Neurological Disorder of Extrapyramidal Motor System:Tremor, loss of speech/motion coherence, high-stepping gait
(velcro feet), mask-like face
- Phase III
Bradykinesia, rigidity
Slide from D. Quig, DD
Ref. Environ Health Perspective (2000)108;429-32
Carl GF, Gallagher BB.
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Manganese and epilepsy.
In: Klimis-Tavantzis DL, ed.
Manganese in health and disease.
Boca Raton: CRC Press, Inc;
1994:133-157.
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discovery of manganese as a cure fordrug-induced dyskinesia was the first
orthomolecular research to verify the
efficacy of mineral therapy for a disease(other than simple deficiency).
http://orthomolecular.org/hof/2008/kunin.html
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Sir Richard KuninOrthomolecular
Hall of Fame
Founder & Leader OMS
Closet Alchemist
Walker of the Talk
NOTE:
he hasnt aged a bit
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Title Page:Joseph ben
Abraham Gikatilla,
Portae lucis, 1516.
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SUMMARY
andRECOMMENDATIONS
Mineral Digestion A Chelation Process
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Mineral Digestion A Chelation Process
Foods Minerals as protein complexes
Unless bone is consumed to get hydroxyapatite salts
Stomach
Acid causes neutralization of carboxylic acids
Minerals become free ions with chloride and phosphate ascounter-ions
Duodenum
Alkaline pancreatic juice neutralizes chyme
Carboxylic acids take on negative charge again
New chelates and complexes formSmall intestine
Selective uptake of ionic forms under tight control ofregulatory proteins
Your best mineral supplement?
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1) Avoid milk (antacid)
2) Betaine HCL and pepsin
with each meal
layer it in with foodBetaine HCL (COH, protein, fats) + Pepsin (splits proteins)
Dropping Acid
see http://weeksmd com/?p=96
ee cummings
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ee cummings
"Oh, sweet spontaneous earth, how oftenhave the doting fingers of prurientphilosophers pinched and poked thee, hasthe naughty thumb of Science prodded thy
beauty. How often have Religions taken theeupon their scraggy knees squeezing andbuffeting thee that thou mightest conceiveGods (but true to the incomparable couch of
death, thy rhythmic lover, thou answerestthem only with spring)"
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