Post on 17-Dec-2015
A computational model for the formation of lamin-B mitotic spindle envelope and matrix
by Changji Shi, Wilbur E. Channels, Yixian Zheng, and Pablo A. Iglesias
Interface FocusVolume 4(3):20130063
June 6, 2014
©2014 by The Royal Society
Reactions included in the model.
Changji Shi et al. Interface Focus 2014;4:20130063
©2014 by The Royal Society
Geometric description of the model.
Changji Shi et al. Interface Focus 2014;4:20130063
©2014 by The Royal Society
MT polymerization gives rise to two asters which are pushed away by the MT-based motors.
Changji Shi et al. Interface Focus 2014;4:20130063
©2014 by The Royal Society
The complete model shows that a lamin shell is formed around the MT spindle region.
Changji Shi et al. Interface Focus 2014;4:20130063
©2014 by The Royal Society
Effect of RanGTP on the production of the spindle.
Changji Shi et al. Interface Focus 2014;4:20130063
©2014 by The Royal Society
Comparison of two putative networks for lamin matrix formation.
Changji Shi et al. Interface Focus 2014;4:20130063
©2014 by The Royal Society
Sensitivity analysis for various model parameters.
Changji Shi et al. Interface Focus 2014;4:20130063
©2014 by The Royal Society