2004

Elevated serum AFP more than 100 ng/ml in chronic hepatitis Bpatients without HCC: Follow-up 5–12 MHz SonoCT findings ofhepatic parenchymaCha SH, Chung HH, Lee KY, Lee SH, Seo BK, Kim T-K, Je B-K,Kim BH, Ansan Hospital Korea University, Korea

Objectives: To evaluate follow-up 5–12 MHz SonoCT findings ofhepatic parenchyma with elevated serum alphofetoprotein (AFP) morethan 100ng/ml (EAFP100) in chronic hepatitis B (CHB) patients with-out hepatocellular carcinoma (HCC).Methods: Total 23 CHB patients with EAFP100 were included in thestudy. Interval between the initial and the last 5–12 MHz SonoCTexamination was ranged from 9 to 44 (average 23.5) months andEAFP100 was revealed 1 to 4 times (average 1.7/total 9.7 times) duringthat period. No HCC was detected at more than six months radiologicaland/or clinical follow-up after the last 5–12 MHz SonoCT examination.Two radiologists analyzed changes of 5–12 MHz SonoCT findings ofhepatic parenchyma in consensus and statistical analysis was done.Results: Among 23 cases, 14 (61%) revealed changed and nine (39%)revealed unchanged 5–12MHz SonoCT finding. In changed group,eight (57%) showed normal-looking echo of liver initially but heter-ogenous echo, or multiple, small hypoechoic or hyperechoic nodules onthe last examination. In unchanged group six (66%) showed diffusehypoechoic-honeycomb echo on initial and last examination. Averagefollow up period of changed and unchanged group with 5–12 MHzSonoCT was 22. 4 and 20.2 months, respectively, and statisticallyinsignificant (p � 0.924). Average serum AFP titer of changed andunchanged group was 83.52 and 39.8 ng/ml, respectively, but statisti-cally insignificant (p � 0.052).Conclusions: Follow-up 5–12 MHz SonoCT can help to evaluatehepatic parenchyma with EAFP100 in CHB patients without HCC.

2005

Relation between indexes of spleen and G/S staging in chronicviral hepatitisMiao L, Wang J, Ge H, Peking University Third Hospital, China

Objectives: To discuss the relation between indexes of spleen and G/Sstaging in chronic viral hepatitis.Methods: According to the pathology of needle biopsy, the liverfibrosis status was graded as S0 � S4, and the inflammatory reaction inthe liver was graded as Gl � G4. The discrepancy of spleen indexeswas compared between the case group and the control group andamong G/S stagings.Results: The size of spleen, the inside diameter of splenic artery andvein, the blood flow of spleen were increased as the G/S staging andbecame higher as the patient’s condition became graver. These indexeswere higher in case group than those in the control group. The corre-lation coefficients between SPT and D1SPV, Vs2SPV, SPFV, D2SPV,VsSPA were 0.510, 0.510, 0.447, 0.353, 0.353, respectively.Conclusions: The size of spleen, the inside diameters of splenic arteryand vein, hemodynamic indexes of spleen are helpful to estimate thepatient’s disease.

2006

Relation between pathological changes of gallbladder and G/Sstaging in chronic viral hepatitisWang J, Miao L, Ge H, Peking University Third Hospital, China

Objectives: To discuss the relation between pathological changes ofgallbladder (GB) and G/S staging in chronic viral hepatitis.Methods: According to the pathology of needle biopsy, the status ofhepatic fibrosis was graded as S0 � S4, and the inflammatory reaction

in the liver was graded as Gl � G4. The discrepancy of GB indexeswere compared between the case group and the control group andamong G/S stagings.Results: The size of GB and the thickness of the GB wall in the casegroup were larger and more thick than those in control group. So didthe smooth rate of GB wall. Eight bilateral gallbladders were alloccurred in case group. GB became larger as the G/S staging becamehigher, so did the smooth rate of GB wall and bilateral gallbladder. Thevalue of GB indexes became higher as the patient’s condition becamegraver according to the inflammatory activity of the liver, so did thesmooth rate of GB wall.Conclusions: Pathological changes of GB in chronic virus hepatitiswere related with G/S stagings, the course of disease and the severityof chronic virus hepatitis. A serial observation was made to patholog-ical changes of GB in chronic virus hepatitis which can help doctors tojudge patient’s condition and provide the information for diagnosis andtherapy.

2008

Weakness of visual grading in the diagnosis of fatty liver onultrasound: Result from comparison with quantitativemeasurementLee CH, Choi JW, Kim KA, Park CM, Guro Hospital, KoreaUniversity, Korea

Objectives: To evaluate the weakness of visual grading for fatty liver(FL) through the comparison with hepatorenal echogenicity ratio(HER).Methods: The ultrasound was applied to 281 patients. The echogenic-ity of the liver was measured in three ROI close to the adjacent rightkidney. Similar measurements were performed in the right renal cortex.The HER (mean liver/kidney echogenicity) was then calculated. Thedegree of hepatic echogenicity were classified into normal, mild, mod-erate, and severe using the reference figure on PACS. The statisticalanalysis for multiple comparison of the average HER of the four groupswas carried out using a one-way ANOVA.Results: Among the 281 patients, there were 60 normal (mean HER:1.33), 81 mild FL (mean 1.45), 86 moderate FL (mean 2.03) and 54severe FL (mean 2.46). The HER of the normal and mild FL had nosignificant difference (p � 0.05), but there were significant differences(p � 0.01) between the mild FL and moderate FL, and the moderate FLand severe FL.Conclusions: The weakness of visual grading in the diagnosis of FL onultrasound was differentiation of the mild FL from the normal. There-fore, we proposed that the HER be added as a quantitative value for thedetermination of the brightness of FL, especially in mild FL.

YOUNG INVESTIGATOR AWARD PRESENTATION (I)

2009

Detection of hepatocellular carcinoma capsule by contrast-enhanced ultrasound using LevovistBhattacharjee P, Saito A, Chiba M, Katagiri S, Katsuragawa H,Takasaki K, Tokyo Women’s Medical University, Japan

Objectives: To investigate the diagnostic potential of contrast-en-hanced ultrasound (CEUS) in the detection of hepatocellular carcinoma(HCC) capsule.Methods: Thirty-six HCC nodules (mean diameter; 2.3 cm) from 36patients who had undergone hepatectomy were examined by CEUSusing Levovist with agent detection imaging. We classified the appear-ance of the tumor artery, tumor enhancement and washout into severalpatterns on CEUS. The ultrasound findings and pathological findings

Abstracts P85