STAMPEDEComparisonOpen: Oct-2005Closed: Mar-2013Accrual: 2962

Number of patients1184 A Standard-of-care (SOC)593 B SOC + zoledronic acid592 C SOC + docetaxel593 E SOC + zoledronic acid + docetaxel

Docetaxel: Survival – M1 Patients

Robinson Cell 161:1215, 2015

23%

Mateo NEJM 373:1697, 2015

Local Therapy

Androgen Deprivation

Therapies After LHRH Agonists

and Antiandrogens

Chemotherapy

Postchemotherapy

Death

motherapa

PostchemP t hP h