April 2006 Xosé Mª Fernández European Bioinformatics Institute Ensembl Sep 2006.
Mutation and DNA Repair. Mutation Rates Vary Depending on Functional Constraints.
Eukaryotic Diversity Chapter 28. Protists Protists – eukaryotes; more complex than prokaryotes. 1 st – unicellular - called protists – in 1 big kingdom.
Proteomics Terry Kotrla, MS, MT(ASCP)BB. Human Genome Project Launched 1990 took 13 years Estimated 100,000 human genes would be discovered Only 20,000-25,000.
Next generation sequencing platforms Applications
Chromatin Immunoprecipitation DNA Sequencing (ChIP-seq)
Making Sense of Genomes
Genomes
Yeast as a Model System MBIOS 520/420 September 29, 2005.
Organellar Introns Organellar genomes contain 3 types of introns: 1. Group I 2. Group II (evolutionary precursors to nuclear mRNA/spliceosomal introns)
‘Sanger sequencing’ has been the only DNA sequencing method for 30 years but… …hunger for even greater sequencing throughput and more economical sequencing.
