Alignment methods Introduction to global and local sequence alignment methods Global : Needleman-Wunch Local : Smith-Waterman Database Search BLAST FASTA.
SNU BioIntelligence Lab. () 1 Ch 5. Profile HMMs for sequence families Biological sequence analysis: Probabilistic models of proteins.
Alignment methods June 26, 2007 Learning objectives- Understand how Global alignment program works. Understand how Local alignment program works.
Pair-wise Sequence Alignment What happened to the sequences of similar genes? random mutation deletion, insertion Seq. 1: 515 EVIRMQDNNPFSFQSDVYSYG EVI.
HMM for multiple sequences. Pair HMM HMM for pairwise sequence alignment, which incorporates affine gap scores. “Hidden” States Match (M) Insertion in.
Reminder -Structure of a genome Human 3x10 9 bp Genome: ~30,000 genes ~200,000 exons ~23 Mb coding ~15 Mb noncoding pre-mRNA transcription splicing translation.
SVD methods applied to wire antennae Pelagia Neocleous Kings College London IPAM, Lake Arrowhead Meeting K ING’S College LONDON Founded I 2 8 9.
Ch 5. Profile HMMs for sequence families
Alignment methods
Alignment methods II
Alignment methods and database searching
HMM for multiple sequences