Chapter 9 Structure Prediction. Motivation Given a protein, can you predict molecular structure Want to avoid repeated x-ray crystallography, but want.
Protein Sectors: Evolutionary Units of Three-Dimensional Structure Najeeb Halabi, Olivier Rivoire, Stanislas Leibler, and Rama Ranganthan Cell 138, 774-786,
Biological inspiration Animals are able to react adaptively to changes in their external and internal environment, and they use their nervous system to.
Hidden Markov Models Probabilistic model of a Multiple sequence alignment. No indel penalties are needed Experimentally derived information can be incorporated.
“The instructions for assembling every organism on the planet--slugs and sequoias, peacocks and
Hidden Markov Models
Chapter 15
Understanding the immune system A Challenge or impossible dream.
