SHMT
Purines
5. 10Methylene THF
serine
glycine
Thymidinesynthesis
dUMP
THF
Yasko Methylation Pathway© Content and diagrams may not be reproduced without express permission from NRI and HHI
VDR
MTHFR
MTR
DHPRNOS
MAO A
COMT
COMT
G6PDH
GAD
SOD
GST
OTC
ACAT
MTRRBHMT
MAT
AHCY
CBS
SUOXACE
Tryptophan Tyrosine
Kreb’sCycle
Arginine
Ornithine
UREA
Citrulline + NO
taurine
5 MethylTHF
NeuronalDamage
MicroglialActivation
Peroxynitrite
Super Oxide
glutamate gaba
Serotonin Dopamine
mercurylead
BH4
AMMONIA LEADBH2
ALUM
NorEpSAMe
SAHHIAA
VMA
B12
0 B
H4
1 B
H4
2 B
H4
SAH
HVA
Methionine
Homocysteine
cystathionine
Cysteine + , α-ketobutyrate
glutathione
Guanido AC
adenosine
SAMe
SAH
methylationDMG
TMG SAH
Angiotensin I Angiotensin II
cortisol
AMMONIA
DNA, RNAProtein, lipids
“When the need is for energy and not forcysteine, homocysteine is metabolized to
Alpha-Ketobutyrate, NH3 and H2S.”Text of Biochemistry with Clinical Correlations, Devlin 2002
Creatine Creatinine
glycine
α-ketoglutarate
NADH/FADH
fumarate
succinate
aspartateoxaloacetate
Acetyl CoA
citrate
isocitrate
Pyruvate
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