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Page 1: Unravelling the biological characteristics of MammaPrint ... · normalized enrichmet score ul gsea g2m checkpoint 11.6 jak stat3 signaling p13k akt mtor signaling inflammatory response

70-gene MP

22

UH

-lo

g 1

0(a

dj.

P.V

al)

log2FLC

UH vs. HR

log2FLC

UL vs. LR

-lo

g 1

0(a

dj.

P.V

al)

Activating Invasion & metastasis

Deregulating cellular energetics

Enabling replicative immortality

Evading growth suppressors

Genome instability and mutation

Immune response

70-gene MP UL

546

Department of Research and Development, Agendia, Amsterdam, the Netherlands;

Contact: [email protected]

Hallmarks of Cancer

Unravelling the biological characteristics of MammaPrint extreme risk subgroups

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