Type 1 Diabetes Increases the Expressionof Proinflammatory Cytokines and
AdhesionMolecules in the ArteryWallof Candidate Patients for Kidney
Transplantation
Featured Article:
Javier Triñanes, MSc, Eduardo Salido, M.D., Ph.D., Julián Fernández, M.D., Ph.D., Margartia Rufino, M.D., Ph.D., José Manuel González- Posada, M.D., Ph.D., Armando Torres, M.D., Ph.D., Domingo Hernández, M.D., Ph.D.
Diabetes Care Volume 35:427–433
February, 2012
Study Objective
• To assess the influence of type 1 diabetes on atheromatosis-related inflammation in patients with chronic kidney disease (CKD)
Triñanes J et al. Diabetes Care 2012;35:427-433
Study Design
• Analyzed expression of proinflammatory cytokines and adhesion molecules in inferior epigastric artery walls of type 1 diabetic patients with CKD (n = 22) compared with nondiabetic patients with CKD (n = 92) at time of kidney transplantation
• Evaluated expression of IL-6, MCP-1, VCAM-1, intercellular adhesion molecule-1, and activation of NFkB-p65
• Common carotid IMT determined by conventional echography
Triñanes J et al. Diabetes Care 2012;35:427-433
Triñanes J et al. Diabetes Care 2012;35:427-433
Triñanes J et al. Diabetes Care 2012;35:427-433
Triñanes J et al. Diabetes Care 2012;35:427-433
Triñanes J et al. Diabetes Care 2012;35:427-433
Conclusion
• Type 1 diabetes produces a proinflammatory state in arteries of CKD patients, with increased levels of IL-6, MCP-1, and VCAM-1, and more NFkB- p65 activation
• Associated with more severe vascular lesions and higher c-
IMT
• Findings support major role of inflammation in type 1 diabetic patients with CKD
Triñanes J et al. Diabetes Care 2012;35:427-433
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