Trough FEV1

FF/VI 100/25mcg vs. PBOFF/VI 100/25mcg vs. FF 100mcg

FF 100mcg vs. PBO

1. Rescue-free 24hr periodsFF/VI 100/25mcg vs. PBO

FF/VI 100/25mcg vs. FF 100mcgFF 100mcg vs. PBO

Co-primary

0-24hr wmFEV1

FF/VI 100/25mcg vs. PBOFF/VI 100/25mcg vs. FF 100mcg

FF 100 vs. PBO

2. Symptom-free 24hr periodsFF/VI 100/25mcg vs. PBO

FF/VI 100/25mcg vs. FF 100mcgFF 100mcg vs. PBO

3. AQLQ+12FF/VI 100/25mcg vs. PBO

FF/VI 100/25mcg vs. FF 100mcg

If p<0.05 for co-primary endpoints move to secondary 1.

If p<0.05 for secondary 1. move to secondary 2.

If p<0.05 for secondary 2. move to secondary 3.

Sec

on

dar

y