NT chemical messengers Examples: dopamine norepinephrine GABA
serotonin melatonin
Slide 4
Symptoms of clinical depression change in sleep habits loss of
interest irritability, tension, sadness lack of energy
http://www.depression.com/depression_animation.html
?content=understanding&
http://www.depression.com/depression_animation.html
?content=understanding& Associated conditions anxiety, panic
attacks bipolar disorder OCD
Slide 5
Brand NameGeneric Name Celexa*citalopram Lexaproescitalopram
Paxil*paroxetine Prozac*fluoxetine Zoloft*sertraline *available as
generics
Slide 6
Time to take effect Common side effects nausea insomnia loss of
appetite sexual dysfunction Serotonin Syndrome
Slide 7
Brand NameGeneric Name Cymbaltaduloxetine Effexor*venlafaxine
Effexor XRvenlafaxine, extended release Pristiqdesvenlafaxine
*venlafaxine tablets are available in both regular release &
extended release
Slide 8
Time to take effect Side effect profile similar to SSRIs
Serotonin Syndrome
Slide 9
Brand NameGeneric Name Elavilamitriptyline Pamelornortriptyline
Tofranilimipramine
Slide 10
Common Side Effects Drowsiness/Dizziness Dry mouth Constipation
Sexual dysfunction
buspirone augments serotonin levels trazodone sleep atomoxetine
norepinephrine reuptake inhibitor bupropion No sexual side effects
Lowers seizure threshold Various forms available (regular release
tabs, extended release tabs, sustained release tabs)
Slide 13
Black Box Warning Abrupt Discontinuation Syndrome Interaction
with MAOIs
Slide 14
Brand NameGeneric Name Ativanlorazepam Klonopinclonazepam
Restoriltemazepam Valiumdiazepam Xanaxalprazolam
Slide 15
Drowsiness Impair judgement Respiratory depression Increased
risk of falls in the elderly Controlled substances = highly
addictive
Slide 16
Brand NameGeneric Name Ambien, Ambien Crzolpidem
Lunestaeszopiclone