MAY 9-12, 2022, HYNES CONVENTION CENTER, BOSTON
EARLY CONFIRMED KEYNOTES FOR TIDES 2022
THE WORLD’S LARGEST MEETING TO ACCELERATE OLIGONUCLEOTIDE AND PEPTIDE PRODUCTS FROM EARLY DISCOVERY TO LATE-STAGE DEVELOPMENT & COMMERCIALIZATION
REGISTER BY DECEMBER 17TH AND SAVE $900 • WWW.TIDESEVENT.COM #TIDESUSA
Brett P. Monia, PhDChief Executive OfficerIonis Pharmaceuticals
Ugur Sahin, MDChief Executive OfficerBioNTech AG
Stéphane Bancel, MBAChief Executive OfficerModerna
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TIDES is a ‘must-go’ conference for scientists working in the peptide/oligonucleotide area
THE INDUSTRY’S FLAGSHIP MEETING FOR OLIGONUCLEOTIDE AND PEPTIDE SCIENCE, TECHNOLOGY AND NETWORKING
“ ”George Wang, Analytical Chemist, Bristol-Myers Squibb
Accelerate your pipeline of oligonucleotide and peptide therapeutics to market by applying best practices and lessons learned from 125+ case studies and new data presentations from global industry leaders working across the entire spectrum of development and production.
Bring your product to market by meeting 90+ leading product and service providers showcasing live technology demonstrations in our exhibit hall.
Connect with 1300+ scientists and executives from 30 countries focused in oligonucleotide and peptide development and production during luncheons, cocktail receptions and networking breaks. Networking has never been easier with the included TIDES app that allows you to view the attendee list and schedule meetings before, during and after the event.
Register by December 17th and Save $900 • www.TIDESevent.com
SCIENCE TECHNOLOGY NETWORKING
ACCESS NOVEL SCIENCE ACROSS THE ENTIRE OLIGONUCLEOTIDE, PEPTIDE, AND mRNA SPECTRUMThe TIDES USA program features concurrent tracks covering the following 6 scientific themes including in-depth development strategies, trends, and technologies across the entire spectrum of oligonucleotides, peptides, mRNA, and genome editing. Your registration provides access to the presentations across all tracks, allowing you to create your own customized agenda.
Oligonucleotide Chemistry, Manufacturing & Controls
Peptide Discovery, Preclinical and Clinical
Oligonucleotide Discovery, Preclinical and Clinical
mRNA Therapeutics/Vaccines & Genome Editing
Peptide Chemistry, Manufacturing & Controls
Drug Delivery Innovations
Comprehensive CMC, analytical, manufacturing and regulatory strategies for both drug substance and drug product to accelerate oligonucleotide product development.
Explore new frontiers in peptide synthesis, discovery, design and engineering to improve targeting, delivery and drug-like properties. Case studies on the latest preclinical and clinical successes of peptides and peptide-like scaffolds and structures.
Design oligonucleotides with better drug-like properties to accelerate your products to the clinic and to market. The latest preclinical and clinical updates to benchmark your research and improve your clinical efforts.
Hear updates on discovery strategies, clinical progress and CMC approaches for mRNA therapeutics and vaccines from industry-leading companies, and learn about state-of-the-art technologies for genome editing applications and hear about progress in genome editing delivery.
Improve process efficiencies and overcome challenges in process development, CMC and manufacturing. Understand regulatory expectations, new technologies and alternative approaches for emerging complex molecules.
Explore new technologies and approaches in the delivery of macromolecular therapeutics featuring multiple case studies of the delivery of oligonucleotides, peptides, mRNA therapeutics and genome editing delivery strategies. Learn about cutting-edge delivery advances including targeted delivery approaches for oligonucleotides, device-based delivery strategies and oral delivery of peptides.
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Full-Day Training Course * 9:00am – 5:00pm
Introduction to Analytical Control Strategies for Therapeutic Oligonucleotides from Early Development to Registration
Course Leader: Mike Webb, Ph.D., Founder and CEO, Mike Webb Pharma
Morning Half-Day Workshops • 8:00am-12:00pmWorkshop #1: Use of Scientific Tools to Support Accelerated Development of Oligonucleotide Therapeutics: Opportunities and Challenges
Workshop Co-Moderators:G. Susan Srivatsa, Ph.D., President, ElixinPharmaFran Wincott, Ph.D., Wincott & Associates, LLC
Workshop #2:How to Bring a Peptide Drug to Market from Discovery to Commercialization
Workshop Moderator: Trishul Shah, Director, Business Development and Head of Sales, North America, PolyPeptide Group
Workshop #3:
An Introduction to mRNA Technology: Discovery, Development, Delivery and CMC
Workshop Moderator TBA
Afternoon Half-Day Workshops • 1:00pm-5:00pmWorkshop #4: Managing Risks in Oligonucleotide Scale-up Manufacturing
Workshop Moderator: Doug Brooks, Ph.D., Principal Consultant, Matapalo LLC
Workshop #5: Peptide Drug Product Strategies: Analytical Characterization, Formulation and Fill-Finish
Workshop Moderator: Marc Jacob, Ph.D., Director of Business Development, Analytical Services, Ampac Analytical Laboratories Services
Workshop #6: LNP Formulations - Design, Synthesis, Chemistry and Manu-facturing of Lipids
Workshop Moderator TBA
Main Conference • Tuesday-Thursday, May 10-12, 2022
Keynote Speakers
Development of ASOsBrett P. Monia, Ph.D., Chief Executive Officer, Ionis Pharmaceuticals
Advances in Development of mRNAStéphane Bancel, Chief Executive Officer, Moderna
Advances in Development of Novel Therapeutics and VaccinesUgur Sahin, M.D., Chief Executive Officer, BioNTech AG, Germany
Pre-Conference Workshops and Training CourseMonday, May 9, 2022**Choose 1 Full Day Training Course OR 1 Morning + 1 Afternoon Workshop
PRELIMINARY AGENA (AS OF DECEMBER 3, 2021)
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Oligonucleotide Sessions
Update on Wave’s ADAR Editing Platform and Preclinical AATD ProgramPaloma Giangrande, Ph.D., VP Platform Discovery Sciences, Biology, Wave Life Sciences
Oligonucleotides for CNS and Cardiometabolic DiseasesSession Chair: Elena Feinstein, M.D., Ph.D., Industry Expert and Consultant, Israel
Targeted Delivery of Conjugated siRNA/ASO to Specific Subsets of Neurons via Intranasal Administration Route for Treatment of Neurological and Psychiatric DisordersAnalía Bortolozzi Biassoni, Researcher, Neuroscience & Experimental Thera-peutics, Institute of Biomedical Research of Barcelona, Spain
Targeting Non-coding RNAs for Prevention of Post-Myocardi-al Infarction Heart Failure and for Treatment of Various Types of Cardiomyopathies Thomas Thum, M.D., Ph.D., CSO and Founder, Cardior Pharmaceuticals, Germany
New Technologies for Targeting RNA and Genomic DNA Session Chair: Punit Seth, Ph.D., Vice President, Medicinal Chemistry, Ionis Pharmaceuticals
RNA editing Howard Stern, M.D., Ph.D., Chief Scientific Officer, Korro Bio
Artificial IntelligenceAmit Deshwar, Vice President of Predictive Systems, Deep Genomics
DS DNA - Using Dervan Peptides to Target Genomic DNAAbhijit Bhat, Ph.D., Head of Research & Development, Design Therapeutics
Therapeutic Upregulation of Gene Transcription by Antisense Oligonucleotide Targeting of Regulatory RNAs; Long ncRNADavid Bumcrot, Ph.D., Chief Scientific Officer, CAMP4 Therapeutics
RNA Base Editing Gerard Platenburg, Chief Innovation Officer, ProQr Therapeutics, The Nether-lands
Characterization of Novel Exon-51 Skipping Oligonucleotides that Safely Rescues Dystrophin Expression in a Severe Model of Duchenne Muscular DystrophyMaria Hedlund, Ph.D., Senior Scientist, BioMarin Pharmaceutical
Antisense Oligonucleotide Therapeutics for Severe Genetic Epilepsies Using Human Cell-based ModelsGraham Dempsey, Ph.D., Chief Scientific Officer, Q-State Biosciences
Examples from Secarna’s Preclinical Anti-fibrotic and Immu-no-oncology PipelineFrank Jaschinski, Ph.D., Chief Scientific Officer, Secarna Pharmaceuticals, Germany
Small Activating RNA from Concept to Phase 2 Clinical TrialsNagy Habib, Head of R&D and CMO, MiNA Therapeutics, United Kingdom
mxRNA™: miniaturized RNAi Triggers Composed of Single OligonucleotidesDmitry Samarsky, Ph.D., Chief Technology Officer, Sirnaomics
PRELIMINARY AGENA (AS OF DECEMBER 3, 2021)
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Oligonucleotide Sessions (Continued)
Case Studies of Preclinical and Clinical Oligonucleotides in DevelopmentSession Chair: Troels Koch, Ph.D., Senior Vice President, Chemistry, MiNa Therapeutics
Preclinical and Clinical Oligonucleotide UpdateJennifer Lockridge, Ph.D., SVP, Program Development, Dicerna Pharmaceuti-cals, Inc. (Invited)
Regulatory Perspectives on Oligonucleotide TherapeuticsRao V. Kambhampati, Ph.D., Senior Regulatory Review Scientist, CDER Expert on CMC of Oligonucleotides, FDA (Invited)
Oligonucleotide CMC and Analytical StrategiesNitto Avecia Speaker TBA
CMC Regulatory Strategies for OligonucleotidesSession Chair: Thomas Rupp, Owner and Principal, Thomas Rupp Consulting AG, Germany
New Trends and CMC Strategies in Synthesis and Manufactur-ing of Long RNASession Chair: Yogesh Sanghvi, Ph.D., President, Rasayan, Inc.
Innovations in Synthesis for Long mRNA and Non-coding RNA Hari Pujar, Ph.D., Chief Operating Officer, Tessera Therapeutics
CMC and Manufacturing of Long RNAKristy Wood, Ph.D., Vice President, Nucleic Acid Therapeutics Development and Manufacturing, Intellia Therapeutics
Semi-automated Analysis of Oligonucleotide HPLC-UV/MS Data for Chemical Process Development Using Genedata Ex-pressionistTim Nagel, Ph.D., Scientist, PTDC – Analytical Research and Development / Hyphenated and Special Technologies, F. Hoffmann-La Roche, Switzerland
Flexibility Meets Efficiency: Platforms for Purity and Impurity Profiling of Synthetic Oligonucleotides in Early Drug Discovery Using Mass SpectrometryKathrin Stavenhagen, Ph.D., Senior Research Scientist, Medicinal Chemistry, Research and Early Development, Respiratory and Immunology (R&I), Bio-Pharmaceuticals R&D, Astrazeneca, Sweden
New Approaches for Long RNADan Anderson, Founder, Orna Therapeutics
Synthesis and Manufacturing of Long RNADavid Butler, VP Chemistry, Korro Bio (Invited)
Endless RNADiego Miralles, CEO, Laronde (Invited)
Automation and Industry 4.0 Concepts in Commercial Manu-facturing of Oligonucleotides and PeptidesSession Chair: Trishul Shah, Director, Business Development and Head of Sales, North America, PolyPeptide Group
Industry 4.0 Manufacturing ConceptsBachem Speaker TBA
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Oligonucleotide Sessions (Continued)RNAi Therapeutics for Cardiometabolic Disease: the Start of a New AgeJoshua R. Friedman, M.D., Ph.D., Senior Director, Clinical Research, Alnylam Pharmaceuticals U adaptorPeter Ghoroghchian, Ph.D., Co-Founder, President and CEO, Ceptur Therapeu-tics LGC’s Approach to Tackle a Complex Aptamer Manufacture: A Case StudyXibo Li, Ph.D. Associate Director, Oligonucleotide Process Development & Manufacturing, LGC
Peptide Sessions
Bicyclic Peptides (Bicycles), A New Anti-infective ModalityMichael Skynner, Ph.D., Chief Operating Officer, Bicycle Therapeutics, United Kingdom
Peptides (and Oligonucleotides) in Orphan IndicationsSession Chair: Bruce Morimoto, Ph.D., Vice President, Cerecin, USA
Developing Peptide Therapeutics Against GPCRsSession Chair: Rami Hannoush, Ph.D., Partner - US Ventures, Mubadala Cap-ital
GPCR Peptide TherapeuticsSri Kosuri, Co-founder and CEO, Octant (Invited)
Structural Biochemistry of GPCRsPatrick Scheerer, Ph.D. Professor, Charité – Universitätsmedizin Berlin, Ger-many (Invited)
Developing Peptide Therapeutics Against GPCRsPeter McNamara, Head of Research, Tectonic Therapeutics (Invited)
Peptide Agonists as TherapeuticsSession Chair: Rami Hannoush, Ph.D., Partner - US Ventures, Mubadala Cap-ital
Development of Therapeutic Peptide AgonistsSoren Ostergaard, Scientist, Novo Nordisk (Invited)Protein Engineering for Wnt Pathway Agonists for Therapeu-ticsYang Li, Ph.D., Senior Vice President, Biology, Surrozen
Learning Relationship between Chemical and Physical Stabili-ty of Peptides: Tools for Predicting Therapeutic Peptide Be-havior during Drug DevelopmentKatelyn Smith, Ph.D., Associate Principal Scientist, Merck & Co., Inc.
Peptide Agonists as TherapeuticsSachdev Sidhu, Founder, antlerA (Invited)
Next-generation Peptide Discovery PlatformsJigar Patel, Ph.D., Founder & CEO, Nimble Therapeutics
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PRELIMINARY AGENA (AS OF DECEMBER 3, 2021)
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Peptide Sessions (Continued)
Next-Generation Peptide Libraries for DiscoveryRajinder Singh, CSO, Circle Pharma (Invited)
Peptide DiscoveryHiroaki Suga, Professor, University of Tokyo (Invited)
Theranostics, Radiopharmaceuticals& Tumor Imaging with PeptidesSession Chair: Ved Srivastava, Ph.D., Vice President of Peptide Chemistry, Intarcia Therapeutics
Peptide-Drug Conjugates as Tumor Targeted TherapiesSession Chair: Jesse Dong, Ph.D., Vice President, Peptide Chemistry, BioN-Tech
Delivering Immunotherapy to Tumors using an Engineered Peptide-Immunostimulant Conjugate Caitlyn Miller, Researcher, Stanford University
Update on the OncoFap Program Samuele Cazzamalli, Head of Small Molecule Therapeutics, Philogen
Peptide-Drug Conjugates Fredrik Lehmann, Head of R&D, Oncopeptides (Invited)
Peptide-Drug Conjugates Christian Marsolais, SVP and CMO, Theratechnologies (Invited)
Innovations in Peptide Therapeutic DiscoverySession Chair: Jesper Lau, Ph.D., Vice President, Chemical Biology, Novo Nordisk A/S, Denmark
Discovery and Optimization of the all-D-peptide Parkinson’s Disease Drug Candidate SVD-1 with Its α-synuclein Oligomer Disrupting Mode of ActionDieter Willbold, Ph.D., Director, Forschungszentrum Jülich, Germany
Peptide Nucleic Acid Manufacturing and Formulation: Unlock-ing the Promise in Rare DiseaseDietrich Stephan, Ph.D., CEO, NeuBase Therapeutics
Preclinical Efficacy of a Lipooligosaccharide Peptide Mimic Candidate Gonococcal VaccineMichael Pennington, Ph.D., CSO, Ambiopharm
Peptide CMC and ManufacturingSession Chair: Christopher McGee, Ph.D., Senior Director, Business Develop-ment, BachemPeptide Therapeutic Technical Case Study Jon Holbech Rasmussen, Ph.D., Director, Global Development, PolyPeptide Group, Sweden
Peptide Manufacturing Case Study Bachem Speaker TBA
Tirzepatide, A Once-weekly Dual GIP and GLP-1 Receptor Ag-onist: CMC Considerations for Development of a High Volume Complex Synthetic Peptide Michael Kopach, Ph.D., Senior Research Advisor, Eli Lilly and Company
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mRNA Therapeutics/Vaccines and Genome Editing Sessions
Programming mRNA for Cancer ImmunotherapyTasuku Kitada, Ph.D., President and Head of R&D, Strand Therapeutics (Invited)
Gram-Scale Good Manufacturing Practice (GMP) Single Guide RNA for CRISPR-based Gene EditingJoe Guiles, Ph.D., Head of Development, Agilent Technologies
mRNA in Infectious Diseases Session Chair: Andreas Kuhn, Ph.D., Senior Vice President RNA Biochemistry & Manufacturing, BioNTech RNA Pharmaceuticals GmbH, Germany
CMC Strategies for mRNAJames Thompson, Ph.D., CMC Therapeutic Area Lead, Moderna Therapeutics (Invited)
mRNAEric Marcusson, Ph.D., Co-Founder and CSO, Providence Therapeutics
Prime EditingJennifer Gori, Ph.D., Vice President, Research, Prime Medicine (Invited)
RNA EditingDong Wei CEO, EdiGene (Invited)
RNA EditingKen Prentice, VP, Head of Process and Product Development, Shape Thera-peutics, Inc.
Drug Delivery Strategies in Genome EditingSession Chair: Rubina Parmar, Ph.D., Senior Director, Chemistry and Delivery Sciences, Intellia Therapeutics
ATTR, Ex Vivo Program UpdateIntellia Therapeutics Speaker TBA
New Technologies in Genome EditingSession Chair: Cecilia Fernandez, Ph.D., VP of Strategic Planning and Opera-tions, Chroma Medicine
Improving Delivery Mechanisms in Gene editing with mRNA Technology Eric Huang, Ph.D., General Manager and Chief Scientific Officer, Moderna Genomics (Invited)
Base EditingNicole Gaudelli, Head of Genome Editing, Beam Therapeutics (Invited)
Emerging Editing TechnologiesJonathan Finn, CSO, Tome Bio (Invited)
Clinical Data From Ongoing Phase 1/2 BRILLIANCE Clinical Trial Of EDIT-101 For LCA1Lisa Michaels, M.D., Executive Vice President and Chief Medical Officer, Edi-tas Medicine
In Vivo CRISPR Base Editing to Treat ASCVDAndrew Bellinger, M.D., Ph.D., Chief Scientific Officer, Verve Therapeutics
Register by December 17th and Save $900 • www.TIDESevent.com
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mRNA Therapeutics/Vaccines and Genome Editing Sessions (Continued)
CRISPR/Cas9-mediated Genome Editing in Mice: Results from 500 projectsLin Wu, Ph.D., Director, Genome Modification Facility, Harvard University
Exosomal DeliveryKonstantin Konstantinov, Manufacturing & Process Sciences Executive Vice President, Codiak Biosciences (Invited)
Delivery of CRISPR TherapeuticsTony Ho, EVP and Head of R&D, CRISPR Therapeutics (Invited)
Extra-Hepatic LNPsGaurav Sahay, Associate Professor, Pharmaceutical Sciences, Oregon State University Delivery Sessions
Novel Delivery Technologies for MacromoleculesSession Chair: Stephen T. Spagnol, Ph.D., Associate Director, Large Molecule Drug Product Development, Johnson & Johnson
Peptide ConjugatesAndy Boswell, Scientist, Genentech (Invited)
Peptide Conjugation and Reprogramming of CellsRami Hannoush, Ph.D., Partner – US Ventures, Mubadala Capital
Endosomal Escape Vehicle (EEV)-Conjugation Enhances Functional Delivery of OligonucleotidesLeo Qian, Ph.D., Co-founder and Vice President, Discovery Research, Entrada Therapeutics
Going Beyond GalNAc Conjugates: Challenges and Opportuni-ties in Targeted DeliverySession Chair: Muthiah (Mano) Manoharan, Ph.D., Senior Vice President of Drug Discovery, Alnylam Pharmaceuticals
An Overview of Emerging Trends in Drug DeliveryMuthiah (Mano) Manoharan, Ph.D., Senior Vice President of Drug Discovery, Alnylam Pharmaceuticals
Antibody-Oligo Conjugates and DeliveryArthur Levin, Ph.D., Chief Scientific Officer, Avidity Biosciences
Targeted Delivery of ASO TherapeuticsPunit Seth, Ph.D., Vice President, Medicinal Chemistry, Ionis PharmaceuticalsFORCE(TM) Platform for Targeted Delivery of Oligonucleotide Therapeutics in Muscle DiseasesTimothy Weeden, Senior Director, Head of Platform Development, Dyne Ther-apeutics
The Design of Lipid Nanoparticles to Enable Delivery of Di-verse Nucleic Acid Payloads Beyond the HepatocytePeter Lutwyche, Ph.D., President & CEO, Genevant Sciences Corp., Canada
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Delivery Sessions (Continued)
The Nanoprimer: A Nanoparticle Designed to the Efficacy of Nucleic Acid-based TherapeuticsJulie Devallière, Ph.D., Senior Team Leader, Biology, Curadigm, France
Development of an UV Spectroscopy-based Machine Learning Model to Characterize Lipid Nanoparticle Drug Delivery Sys-tem of Nucleic AcidsZhenqi (Pete) Shi, Ph.D., Principal Scientist, Genentech
Delivery of RNA Therapeutics: The Great Endosomal Escape!Steven Dowdy, Ph.D., Professor, Cellular and Molecular Medicine, UCSD School of Medicine
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EXHIBITORSSPONSORSDIAMOND SPONSOR
EVENT SPONSORS
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MEET THE PEOPLE BEHIND THE PRODUCTS & GET THE ANSWERS YOU NEED
Almac Group
Alturas Analytics
AM Chemicals
Aspen Pharma
BCN Peptides
Bio-Works Sweden
Biotage Sweden AB
Biotechlogic
Boston Analytical
CEM
CPC Scientific
Cytiva
DAISO Fine Chem
EMD Millipore Corporation
emp Biotech GmbH
EUROAPI
Evonik
GenePharma
Glen Research
RIBOBIO
Herbert Brown Pharma & Research
JenKem Technology
Kinovate Life Sciences
LGC, Biosearch Technologies
Lifecore Biomedical
Organix, Inc
Pace Analytical Life Sciences
Pall Corporation
Piramal Pharma Solutions
Shanghai Hongene Biotech Corporation
Singota Solutions
Symbiosis Pharmaceutical Services
Teledyne ISCO
Tosh Bioscience
Waters Corporation
YMC Process Technologies
For more information on how you can connect with key buyers at TIDES 2022, contact: A-H: Michael Dunnet, Phone: +1 (617) 960-6173 | E-mail: [email protected]
I-Z: Michael Moriarty, +1 (646) 895-7412 | E-mail: [email protected]
ONLINE:TIDESevent.com
CALL888-670-8200 OR+1-941-554-3500
WAYS TO REGISTER3 EMAIL
Also Consider Attending POSTER PRESENTATIONS GROUP DISCOUNTS:
AsiaTIDES 202214-16 September 2022Westin Miyako KyotoKyoto, Japan
TIDES Europe 202216-18 November 2022 AUSTRIA CENTER VIENNAVienna, Austria
Share your company’s latest research by presenting a poster at TIDES 2022. All posters are displayed inside the exhibit hall throughout the meeting. The deadline to submit a poster abstract is April 8, 2022.
Learn More & Submit Poster Abstract
Register a group of 3+ to receive additional savings.
To register your group, please contact:
Jessica Purnell
or +44 (0)20 7551 9521
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2021 REGISTRATION AND PRICING
IN–PERSON PASS SAVE $900 Register by December 17, 2021
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