T H O M S O N S C I E N T I F I C
Bonnie SnowResearch Director, Clinical Content & Applications
What’s New: Sept 2007 – March 2008
SLA Pharmaceutical & Health Technology DivisionSpring Meeting, April 2008, St. Petersburg, FL
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Thomson Pharma® Content
• Drugs - more than 28,000 (approx. 150 added each month)
• Companies - 7,500 (includes other organizations involved in drug development, e.g., academic, government)
• Meetings – 400 meetings/year, information from key conferences published overnight
• Patents - information from 41 patent-issuing authorities
• Journals – information from more than 11,000 peer-reviewed journals
• Compounds – more than 3 million (approx. 5,000 added each month)
• Sequences – more than 8 million (approx. 16,000 - 20,000 added each month)
• Targets – 5,200+
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Content is delivered in structured, cumulative reports
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Content
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Specialty Current Awareness Home Pages
• Biology
• Chemistry
• Clinical Pipeline
• Clinical Trials
• Licensing & Business Development
• Competitive Intelligence
• News & Meetings
• Intellectual Property
• Regulatory Affairs
• Brand Management
• Generic Competition
• Create your own……
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Each Subject or Specialty homepage provides a selection of current awareness portlets.
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What’s New?
• Detailed information on DEALS in Thomson Pharma– A “Deal” is a collaborative or licensing agreement between two
companies
• Thomson Pharma Drug & Company Reports already incorporate textual summaries of licensing agreements
– Reports now include links to Deal Reports for additional information about each agreement
• Enhanced coverage introduced in September 2007– Separate reports on each Deal, with detailed financial data and event
history• Highly structured, “fielded” data provides advanced search
capabilities– Two new current awareness portlets, filterable by therapy area
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Two new current awareness portlets introduced on the Licensing & Business homepage
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Users can add these portlets to their personal homepages, along with other preferred selections from a menu of 25 current awareness portlets now available in Thomson Pharma®
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T H O M S O N S C I E N T I F I C
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T H O M S O N S C I E N T I F I C
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T H O M S O N S C I E N T I F I C
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Search Form [continued]:
Additional DEAL filtering options
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DEAL FINDER capability added to Guided Search options
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What’s New?
• New Specialty section devoted to Clinical Trials
• Two new types of reports added to Thomson Pharma– Structured summaries of trial Protocols and Outcomes
• Determine status & progress of clinical research not just at the drug and company level, but also at the specific study level: e.g., number of studies, size and scope, expected duration
• Compare outcomes measures used, drugs identified as active controls, randomization and masking, patient eligibility parameters
• Adapt trial design & development program to address emerging competitive issues & ensure that evidence obtained from studies is not only adequate for product approval, but also for effective product positioning & rapid adoption, once launched
• Site and clinical investigator selection• Identifying trends and benchmarking
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What’s New?
• New Specialty section devoted to Clinical Trials
• Two new types of reports added to Thomson Pharma– Structured summaries of trial Protocols and Outcomes – Linked to relevant Drug and Company Reports in Thomson
Pharma
• New current awareness portlets to assist in monitoring trial developments
• Sources: company websites, press releases, conferences, journals, protocol registries, including Clinical Trials.gov, ISRCTN register, WHO ICTRP portal (China, India, Australia/NZ), Japan, IFPMA portal
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New Specialty Section & Current Awareness Portlets
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Adjust time period & units (weeks/months) depicted in
display
Change to tabular summary, if desired
Hovering over a given data point
invokes display of further details
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Protocol Trends portlet – User interaction with graph affects content of histograms
Clicking on data elements in histograms leads directly to designated protocols
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Direct link to associated Outcomes Report, when available
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Sponsors & Collaborators: Standardized T-Pharma organization names
Added organization classification: Industrial, Academic, Government
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Study Phase terms:
Not specified
Phase 0
Phase 1
Phase 1/Phase 2
Phase 2
Phase 2a
Phase 2b
Phase 2/Phase 3
Phase 3
Phase 3b
Phase 4
Enhance minimum standards set by FDA & WHO with additional controlled vocabulary/thesaurus terms
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• INTERVENTIONS– Name [standardized T-Pharma drug name + synonyms]– Role (Primary Intervention, Active Control—coordinated
with named compounds)
Intervention Types:
Drug
Gene Transfer
Vaccine
Device
Procedure
Behavior
Drug Combination
Cell Therapy
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Basic data provided by study sponsor enhanced with Thomson Pharma value-added indexing
• Conditions (sponsor’s keywords + T-Pharma Indication, Therapeutic category, Action terms)
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T H O M S O N S C I E N T I F I CData Elements in RED = Value-Added Indexing
Point & click search routines developed to retrieve related protocol records
Associated Biomarkers
Type:
Discovery/validation of disease markers
Discovery of therapeutic effect markers
Measurement of therapeutic effect markers
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Adding controlled “Ethnicity” terms, when applicable + MeSH age groups
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Adding standardized TPharma organization names + controlled country names + regional classification
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Links to Thomson Pharma Drug & Company Reports + full text of primary source
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An entirely new set of index terms was created to facilitate searches on treatment details. Users will be able to view menus of predictable vocabulary for “units of measure’ when searching on dose levels or duration of regimen, plus standardized terms for route & frequency of administration.
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Value-add: Tabular summaries of adverse event data + controlled (predictable) vocabulary for events, including AE Category terms
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Outcomes Reports integrate & accumulate data derived from
multiple sources.
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Option to search specific factors in treatment regimens
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• Clinical Trial Section Scope – 7.3 Release (Sept 2007 - )
• Protocols & Associated Outcomes Reports for:
– Three indications (specific conditions)
• Alzheimer’s• Rheumatoid Arthritis• Diabetes (and its
complications)– All three offered as part of basic
Thomson Pharma subscription– More than 2,200 reports provided
as a working example of the depth & quality of indexing + powerful search capabilities
• In 2008, extending scope to include coverage of all therapeutic areas currently covered in the Thomson Pharma investigational drug database.
• Segments for each additional therapeutic area (consisting of both Protocols and Outcomes Reports for all related indications) will be released in a succession of optional add-ons to basic subscription throughout 2008, as indexing in each therapeutic area is completed.
– Cardiovascular – March
– Neurological – May
– Infection – June
– Gastrointestinal – August
– Immune Disorders - Sept
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What’s New?
• Smart Alerts
• Designed to capture new associations that would be very difficult to find using standard search techniques
– First product patent filed by a company on a new target
– First time link of a target with a therapy area on a patent
– First third-party patent on any drug
– First occurrence of an action term in a patent
– First patent filing for a company
– First time joint patent filings between two organizations
– First time occurrence of an action term on a drug
– New chemical structures that have been added to drug reports
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How is the Information Displayed?
HOMEPAGE: Competitive Intelligence
New Portlet: Smart Alerts– Filterable by Therapy Area
– Set up email alerts
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Filter the information by therapy area, patent owner
etc. to produce a more refined results list
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What’s New? Entelos Reports
• Entelos Inc., the leader in predictive biosimulation, develops computer models of human physiology and creates “virtual patients” to optimize pharmaceutical and biotechnology research and development.
• PhysioLab ® technology is used to test novel interventions, predict efficacy, assess safety, optimize product development, and better position existing products in competitive markets.
• Entelos Reports provide unique predictive content about a specific biological target.
• Access Entelos reports from a hot-linked logo on the Thomson Pharma homepage or from the ‘Browse Targets’ menu
• Three types of report will be available– Target, Clinical, and Commercial
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Overview of the 8.1 release (March 2008)
Latest enhancements to Thomson Pharma focus on visualization tools for analysis and streamlined navigation
• Improved charting/‘Rank by’ options• Bar charts• Pie charts• Matrices
• Star Tree/Hyperbolic Tree visualizations
• Metadata Fingerprints
• PLUS another option for current awareness: RSS Feeds
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Rank by – Bar Charts
• New format bar charts– Interactive: click on a
chart segment to view corresponding results
– More ‘Rank by’ options, including parent company, originator
– Ability to select up to 70 top ranking items per chart
– Specify parameters and chose cut-off limits
– Option to select a subset of results to drill down and analyze further
Benefit: Enables quick detection of patterns within your results and jump to specific subsets identified through ranking
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Rank by – Pie Charts
• Additional visualization option– Interactive chart, click on a
segment of the pie to view those specific results
– Uses same ‘Rank by’ options as the bar charts
– Ability to chart up to 20 top-ranking items within the data element designated for analysis
– Option to select a subset of results to drill down and analyze further
Double click on a segment of the pie chart to isolate a
specific subset within your search results
Hover over a segment to see more details
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Rank by – Matrix Display
• Two-dimensional matrices show relationships within results
– Analyse two fields (e.g. action vs. therapy area) at a glance to detect patterns & trends
– Interactive chart: click on any number to view those specific records
– Color codes: the darker the color, the larger the number of corresponding results
– Option to select a subset of results to drill down and analyse further
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Star Trees
• Hyperbolic Trees (Star Trees) – Give you the ability to explore
and analyse drug and patent results lists in a new visual form
– Allow users to navigate and explore hierarchical relationships and drill-down to information of interest
– Fully interactive charts• Colour coded• Movable, can re-centre
around a different point of interest
– 2 predefined options or The displayed can be moved around to view the chart from
different angles
Change the display options e.g. colour coding, format
Benefit: Allows users to navigate and explore hierarchical relationships and drill-down to information of interest
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Metadata Fingerprints
• Show the content associated with each report
• Enable you to filter your results by report attributes
– Click on a segment to narrow down your results to items containing the selected attribute
– Advanced filtering options enable you to exclude, as well as include, designated information in your results list
Benefit: Makes it easy for users to determine which reports are of most interest, without having to open them
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RSS Feeds
• Set up RSS feeds out of Thomson Pharma from 8 of the homepage portlets e.g. meetings
– Recommended to use either Internet Explorer 7 or Firefox 2
Benefit: Content of Thomson Pharma current awareness portlets can be displayed alongside other news feeds of interest to users
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System Requirements
• In order to benefit from the latest enhancements to Thomson Pharma, and to continue using the ‘rank by’ function, users must have the following plug-ins installed on their pcs
– Java version 1.4 or above http://wwww.java.com
– Adobe Flash Player 9 or above http://www/adobe.com/products/flashplayer
• These plug-ins are free to download
• If you do not have the correct plug-in a message will be displayed alerting you to the fact
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