Spectrum’s mission is to provide quality Membrane Separations Technology to
the Life Science market
Tangential F
low
Filtra
tion Solutio
ns
Tangential Flow Filtration
Shanghai, Oct. 26, 2011
Yingqing Huang, General Manager for Greater China
• Introduction to TFF• Applications• Challenges• Our Offerings
– Membranes, mPES,– System, KRIIi– Single Use Technology
• Designed for Scalability• Summary
Overview
Hollow Fiber TFF
• Effective Reduction of Membrane Fouling
• Tubular Membrane Geometry
• Large Surface Area in a Compact Size
• Gentle Separations with Relatively Low Pressure
• Available in UF and MF pore size ranges
• Directly Scalable by Increasing Number of Fibers
Applications
• Alternatives to centrifugation, depth filtration, etc.• Separation • Purification• Sterilization• Buffer exchange• Concentration
Company Application MERCK Drug delivery, vaccines
ACCELERON PHARMA Theoepeutical rProteins, IgG
NOVARTIS VACCINES & DIAGNOSTICS E.Coli concentration
SAIC FREDERICK Vaccines
BAXTER HEALTHCARE CORP. Pertusis, Mening C
MEDIMMUNE Vaccines
ABBOTT LABORATORIES Diagnostics
INTEGRA BIOLOGICS Bone Repair
AMGEN, INC. Cell Perfusion
ROCHE DIAGNOSTICS Diagnostics, latex
NANOSPECTRA BIOSCIENCES, INC. Gold nanoparticles
BECKMAN COULTER, INC. Diagnostics
GENENTECH INC Cell Culture, drug development
REFINE Perfusion
STEMCELL TECNOLOGIES Particle concentration / reactor
Industries
Challenges
Operation Time
• Membrane fouling• Pressure, flow, TMP, recirculation• System configuration• Interactions of parameters• Scale up loopholes
Our Offerings
• Wide range of membrane selections to meet diversified applications– Materials, SA, Pore size, Geometry, etc.
• Systems for both R&D and productions
• Pre-assembled Membrane, Bags, and Tubing packages to improve your efficiencies
• Direct tech support from application experts
Spectrum Hollow Fiber Modules
• Broadest Range of MWCO’s (1kD through 0.65 µm)
• Membrane Types = PS, mPES, ME, RC, PP
• Small Scale = MicroKros (5 cm2)
• Large Scale = KrosFlo Max module (22 m2)
• Sterile, Non-Sterile
Benefits of mPES Membranes
• Hydrophilic membrane• Low protein binding
& slow fouling• High selectivity • High permeability
• Easier R & D• Stable operations• High performance• Cost effective
Characteristics Benefits
KRIIi makes R&D Easier
• Provides all necessary components for your study
• Automated TMP control• Real time data collection and
graphic analysis• Small footprint• Provide solid data for scale up• Ideal for R&D and low volume
production
KF Comm Data Collection System
• Process data exports directly into MS Excel in real time
• Calculated feed flow rate , shear, TMP, etc.
• Customizable alarm setting for process safety
• Pressure control with non-invasive valves• Real-time graphing (virtual recording)• Make the most of your experiment• Recorded data for analysis
MBT Assemblies
Permeate Flow Meter
Pressure Transmitter
MBT Assemblies
• Reduce your setup or preparation time
• Reduce process variability• Reduce your logistics
burden• Improve your efficiencies
and productivity
Designed for Scalability
• Membrane module sizes• Customizable
Designed for Scalability
KrosFlo Research IIi KrosFlo MiniKros Pilot KrosFlo LDF-55
• Complete line of process systems
• KF Comm Date Collection System generates solid data for scale
up
• Scale up guided by technical sound rationales
MBT Systems for different scales• Compatible with KFComm
data collection systems. • Customizable and optimized
system setup and configuration for different systems
– KR2i – Bench Scale– KMP – Pilot Scale– LDF37 – Production – Khameleon Perfusion
Systems
• Wide selection of membranes including our unique offering of high performance mPES membrane.
• KRIIi research TFF system make your R&D easier.
• Single use MBT system improve your efficiency
• Complete product line and common data collection software ensures smooth transfer for R&D to production.
• Direct onsite technical service available
• Competitive price
SUMMARY
Thank You 多谢光临
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