J. Indian Chem. Soc., Vol. 97, No. 8 Annual Subscription : ` 5000/US $ 600
August 2020 Retail Price : ` 500/US $ 65
Special Issue on “Medicinal Chemistry”
Published by Indian Chemical Society
92, Acharya Prafulla Chandra Road
Kolkata-700 009, India
J. Indian Chem. Soc., Vol. 97, August 2020
Th e I n d i a n C hem i c a l So c i e ty Office-Bearers (2020)
Advisors (Those who have filled the office of the President)
Suresh C. Ameta (Udaipur) Girjesh Govil (Mumbai) D. Banerjea (Kolkata) Jai P. Mittal (Navi Mumbai) D. S. Bhakuni (Lucknow) Dulal C. Mukherjee (Kolkata) Ramesh Chandra (Delhi) K. B. Pandeya (Allahabad) M. C. Chattapadhyaya (Allahabad) R. N. Prasad (Jaipur) Sukh Dev (Bhavnagar) Sunil Kumar Talapatra (Kolkata)
President G. D. Yadav (Mumbai)
Vice-President
R. D. Kaushik (Haridwar) Ashok Kr. Jha (President, Bhagalpur Branch) Hony. Secretary Hony. Treasurer
Chittaranjan Sinha (Kolkata) Sudip Kumar Das (Kolkata) Editor-in-Chief
G. D. Yadav (Mumbai)
Hony. Editors
A. C. Bhasikuttan (Mumbai) Sundargopal Ghosh (Chennai) Chhanda Mukhopadhyay (Kolkata)
Editor (Guest) Shivendu Ranjan (Lucknow/South Africa)
International Executive Editor Bimal K. Banik (USA )
International Editors
Takashiro Akitsu (Japan ) Anil Kumar (India ) Ebbe Nordlander (Sweden )
Members of the Council A. Anton Smith (Annamalai Nagar) K. Mohanan (Trivandrum) Anand S. Aswar (Amravati) Sheo Satya Prakash (Patna) Rakshit Ameta (Udaipur) Ch. Venkata Ramana Reddy (Hyderabad) Samir Biswas (Kolkata) Mahendra Nath Roy (Darjeeling) Nibedita Chakrabarti, Assistant Secretary (Kolkata) R. V. Singh (Jaipur) K. R. Genwa (Jodhpur) Scientist (To be nominated by the DST, New Delhi) R. N. Jadeja (Vadodara) R. K. Vatsa (Mumbai) Asok K. Mallick (Kolkata) Ranjit K. Verma (Munger)
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J. Indian Chem. Soc., Vol. 97, August 2020
Preface
Chemistry underpins everything that the advancement of modern science is associated with.
It plays the pivotal role in the health care system and particularly in the realm of pharmaceutical
sciences. In drug discovery and development, chemistry specifically organic synthesis holds the
central stage. The advancement in chemical research is the key indicator of the economic growth
and the societal development of any country. Chemical research has been one of the major
strengths of our country that earned India the status of the pharmacy of the world. Acharya
Prafulla Chandra Ray has been the doyen of chemical science in India showing it the path and
strength of entrepreneurship that laid the foundation of the pharma sector in the country. Thus, the
Indian Chemical Society has chosen appropriately to pay tribute to its founder Acharya Prafulla
Chandra Ray in organising the International Seminar on “Recent Advancements in Chemistry &
Material Sciences-2020 (RACMS-2020)” through the month of August 2020 to commemorate
his 159th Birth Anniversary. Under the scenario of COVID-19 pandemic and realising the
necessity of development of therapeutics to cope up such unprecedented adverse impact on the
healthcare system the decision of the Indian Chemical Society to dedicate a special issue of the
Journal of Indian Chemical Society on Medicinal Chemistry for the above International
Conference is the most fitting gesture to reflect the act and concern of Acharya Prafulla Chandra
Ray under such a need of the hour. It is our great pleasure that the Special Issue (August, 2020)
has been published with some invited contribution from the practicing medicinal chemists of the
country in various reputed institutes/universities. We cordially acknowledge with heartiest
admiration the scholastic contribution of the authors, who kindly responded promptly with their
articles. We believe that this token gesture of the Indian Chemical Society will further sensitize
the creative minds to focus their research endeavours towards new drug discovery and
development.
G D Yadav Chittaranjan Sinha Asit K. Chakraborti Debprasad Chattopadhyay
Chhada Mukhopadhyay
Sundargopal Ghosh President Honorary Secretary Tapas K. Hazra A C Bhasikuttan
Guest Editors
J. Indian Chem. Soc.,
Vol. 97, August 2020
Journal of the Indian Chemical Society
VOLUME 97 NUMBER 8 August 2020
C O N T E N T S
Article 1
Structure-based Optimization of 2,3-dioxopyrrolidines as Potential Inhibitors
of Flaviviral Methyltransferases
Prajakta Wangikar, Elvis A. F. Martis, Wahiba Aouadi, Santosh R Nandan*,
Etienne Decroly and Evans C. Coutinho*
Article 2
Pharmacophore Mapping and Virtual Screening for the Identification of New
PPARγ Agonists
Smriti Khanna, Sandeep Sundriyal,
and Prasad V. Bharatam*
Article 3
Functionalized Sulfamethoxazole and its metal complex : Structural
characterization, antibacterial and anticancer study of sulfamethoxazolyl-azo-
salicylic acid and its copper(II) complex
Nilima Sahu, Kunal Pal, Faruk Ahmed, Nayim Sepay, Kuladip Jana,
Alexandra M.Z. Slawin, Chittaranjan Sinha*
Article 4
2,4-Diaminotriazines as anti-infective agents
Suparna S. De, Siva K. Vogalu,
Nazima Ansari, Rajendra Patil, Dharmarajan
Sriram, and Mariam S. Degani*
Article 5
Anticancer activity of imidazole fused quinoxalines via human topoisomerase
inhibition
Gaurav Joshi and Raj Kumar*
Article 6
Design, Synthesis and Biological Evaluation of Novel DPP-IV Inhibitors
Chirag Karelia, Kailash Parmar, Divya Teli, Mahesh Chhabria*
Article 7
Design, Synthesis, Anti-cancer Screening, and Structure Activity Relationship
Studies of Biphenyl Linked Fused Imidazoles
Rahul Singh, Mallesh Pandrala, Sanjay V. Malhotra, Ganesh P. Pawar, Vinod
D. Chaudhari, Deepak B. Salunke*
Article 8
Drug Repurposing for Breast Cancer: Preliminary Medicinal Chemistry
Investigations and Future Perspectives
Prashant S. Kharkar*, Chetan P. Shah and Niteshkumar U. Sahu
Article 9
Synthesis and Biological Evaluation of Quinoline-Quinazolinones for
Antimicrobial and Antileishmanial Potential
Shweta Tiwari, Seema Kirar,
Uttam Chand Banerjee,
Neerupudi Kishore Babu,
Sushma Singh, Inder Pal Singh*
Article 10
Synthesis, biological evaluation, and enzyme assay of some 5-N-
substituted-2-N-(arylsulphonyl)-L(+)glutamines as potential anticancer agents
Tarun Jha,* Soma Samanta, Amit Kumar Halder, Nilanjan Adhikari, Sk.
Abdul Amin, Arpita Sanyal, Tanmoy Mukherjee
Article 11
Design, synthesis, and biological evaluation of O-alkyl umbelliferone
derivatives as pancreatic lipase inhibitors
Nisha Yadav, Prashant Auti, Ginson George, and Atish T. Paul*
Article 12
Study of Arginine Mimetic Benzamidine Urea Derivatives as PAD4 Inhibitors
Vadiraj Kurdekar, Satish N. Dighe, and Hemant R. Jadhav*
Article 13
In Silico Identification of a Potent Arsenic Based Lead Drug Di-phenyl
phenoxy roxarsone against SARS-CoV-2
Trinath Chowdhury, Joyita Dutta, Gourisankar Roymahapatra*, Santi M.
Mandal
Article 14
Zinc and copper homeostasis is crucial to maintain the cellular health and their
role in viral diseases
Sneha Mondal, Sounik Manna, Tarun Kr. Barik, Santi M. Mandal,*
Zn
incorporate
Inhibit
viral
replication
Inhibit RT (HIV),
DdDp
(SARC,HSV)
RdRp (influenza)
Inhibit viral
uncoting
NF-κB
Signalling
Inhibited
Article 15
Bioactivity of Azomethines Derived Mechanochemically from 2-Amino
Pyridine and Studies on the Effect of Substituents on the Reaction
Madhushree Das Sarma and Subhojit Ghosh*
Article 16
Ayurveda may play a preventive role against viral infections by the inactivation
of furin protease
Debarati Paul, Trinath Chowdhury, Santi M. Mandal*
Figure 2.
Oleanolic Acid Rosamarinic Acid Ursolic Acid (A)
(A’)
(B)
(B’)
(C)
(C’)
S253
D301 S302
W254
G255 P256
H194
D153
S368
N295
S253
W254
G255 P256
H194
D153
S368
N295
S253
W254
G255 P256
H194
D153
S368
N295
J. Indian Chem. Soc., Vol. 97, August 2020
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ISSN 0019-4522 August 08, 2020 RNI No. 2664/57 JICSAH 97 (8), (2020)
Edited, Printed and Published by the Honorary Secretary on behalf of Indian Chemical Society, Published
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