Simulation System for Emission Tomography (SimSET): using simulation to research ideas in
emission tomography.
Robert L. Harrison, Steven B. Gillispie, Thomas K. Lewellen
University of Washington
Supported in part by PHS grant CA42593
SimSET
• Freely available.
• Photon-tracking simulation.
• PET and SPECT.
• Well engineered.
• Command-line driven.
Using simulation as a research tool
• Problem definition.
• Choosing and installing a simulation.
• Setting up and running a simulation.
• Analyzing the data.
Problem definition
Possible areas of research
• Optimizing patient studies.
• Assessing/improving quantitation.
• Designing tomographs.
Diffuse lung disease
• Reproducing work by Chicco et al.*
• Can disease be detected in SPECT scans of the lungs?
• Cold lesions in hot lung.• Vary size of lesions.• 30% of lung volume affected.
* Chicco, Eur J Nucl Med, 28:150-154.
Choosing and installing a simulation
Choosing SimSET
a
Analyticsimulations(e.g., ASIM)General purposephoton-trackingtomograph simulations(e.g., SimSET,PETSIM, SIMIND)High energy physicssimulations(e.g., GATE, EGS,MCNP, Penelope)Greater flexibility, accuracyGreater speed, ease-of-use
Installing SimSET
• Download from website.
• Unpack (e.g., gunzip).
• Customize links to your system.
• Make run file.
Setting up and running a simulation
General setup
• Scan time, number of decays, …
• Location of parameter files, data tables, etc.
• Object (phantom/patient) geometry.
• Tomograph geometry.
• Output specification.
Defining the object
• Define the activity and attenuation objects.
• We are using the NCAT phantom.*
* Segars and Tsui, IEEE Trans Nucl Sci, 49:3:675-679, 2002.
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Defining the tomograph
• Collimator parameter file.– LEGP.
• Detector parameter file.– Planar detector.
Defining the output
• 62 slices.
• Distance-angle sinograms (128 angles over 360°, 128 3mm distance bins).
• 10% energy window.
Analyzing the data
Analyzing the data
• Filtered backprojection reconstruction.
• Observer study.
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No lesions 8mm3 lesions 16mm3 lesions
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SimSET Summary
• Freely available emission tomography simulation.
• Efficient, easy-to-use.
• Useful for a broad range of research.
For further information
• Website:– http://depts.washington.edu/simset/html/simset_main.html
• Contact:– [email protected]
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