M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 1
Dr. M.G.R
EDUCATIONAL AND RESEARCH INSTITUTE
UNIVERSITY
DEPARTMENT OF MECHANICAL ENGINEERING
M.Tech – CRYOGENIC ENGINEERING
CURRICULUM
2013.
SEMESTER I
Sub.code Subjects L T P C
MCE01 Cryogenic Systems 3 0 0 3
MCE 02 Cryo. Engineering 3 0 0 3
MCE03 Cryo. Mass Transfer and Separation Systems 3 1 0 4
MCE04 Computational Fluid Dynamics 3 1 0 4
MCE05 Semiconductor Devices and Modeling 3 0 0 3
MCE06 Cryo fuel Systems 3 0 0 3
Total 18 2 0 20
i
SEMESTER II
Sub.code Subjects L T P C
MCE07
Fnite Element Analysis
3 0 0 3
MCE08 Computer Aided Design of Cryogenic process plant 3 0 0 3
MCE09 Cryo Heat Transfer 3 1 0 4
MCE10 Gas turbines and jet propulsion 3 1 0 4
MCEE11
Design of Cryo. Equipment and Accessories 3 1 0 4
MCE12 Cryo . Engg. Lab 0 0 3 2
Total 15 3 3 20
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 2
SEMESTER III
Sub.code Subjects L T P C
MCEExx Elective I 3 0 0 4
MCEE xx Elective II 3 0 0 4
MCEE xx Elective III 3 0 0 4
MCE 13 Practical training 0 0 3 2
MCE 14 Project Phase -1 0 0 10 5
Total 9 0 13 19
SEMESTER IV
Sub.code Subjects L T P C
MCE15 Project Phase –II 0 0 30 15
Total 0 0 30 15
LIST OF ELECTIVES
Sub.code Subjects L T P C
MCEE01 Cryobiology 3 0 0 3
MCEE02 Manpower Economics 3 0 0 3
MCEE03 Robotics and sensors 3 0 0 3
MCEE04 Cryo Heat Transfer 3 0 0 3
MCEE05 Cryo tissue Engineering 3 0 0 3
MCEE06 Bioinformatics 3 0 0 3
MCEE07 Cryo physics 3 0 0 3
MCEE08 Quantitative Methods 3 0 0 3
MCEE09
Superconducting Materials, Magnets and Devices
3 0 0 3
MCEE10 Vacuum Techniques 3 0 0 3
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 3
SEMESTER I
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 4
MCE 01 CRYOGENIC SYSTEMS 3-0-0-3
UNIT I 9
Review of Basic Thermodynamics, First and Second Law approaches to the study of
thermodynamic cycles, Isothermal, Adiabatic and Isenthalpic processes.
UNIT II 9
Production of Low Temperatures: Liquefaction systems, ideal, Cascade, Linde Hampson
UNIT III 9
Claude cycles and their derivatives; Refrigerators : Stirling, Gifford-McMahon cycles and
their derivatives.
UNIT IV 9
Cryogenic Insulations: Foam, Fibre, powder and Multilayer. Design of cryogenic storage and
transport vessels.
UNIT V 9
Application of Cryogenics in Industry, Space Technology, Biology and Medicine.
Total hrs: 45
Reference:
1. Cryogenic Systems, by R. Barron 1966.
2. J.H Bell, Crogenic Engineering, 1963
3. R.B.Scott, Crogenic Engineering, 1959
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 5
MCE 02 CRYOENGINEERING 3-0-0-3
UNIT I 9
Review of tree electron and. band theory of solids: Thermal, Electrical and Magnetic
properties of materials at low temperature.
UNIT II 9
Basic properties of Superconductors; Phenomenological theories; out lines of Ginzbarg
Landau and Bardeen-Cooper-Schrieffer theories of superconductivity:
UNIT III 9
Superconducing tunneling phenomena; Introduction to type II superconductivity including
flux flow and critical current density:
UNIT IV 9
High temperature superconductivity and its applications
UNIT V 9
Production of very low temperatures by Adiabatic demagnetization, dilution refrigeration and
nuclear demagnetization and their measurements.
Total hrs: 45
Reference:
1. Cryo genic Fundamentals, by G.G. Haselden, 1971
2. Cryogenic Recycling and processing by Norman R. Braton, 1980
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 6
MCE 03 CRYO MASS TRANSFER AND SEPARATION SYSTEMS 3-1-0-4
UNIT I 12
Principles of Diffusion and Mass Transfer, Fick's Law of Diffusion, Molecular diffusion in
fluids, mass transfer coefficients in laminar and turbulent flow; mass,heat and momentum transfer
analogies.
UNIT II 12
Introduction to the cryogenic gas separation and purification systems; principles of absorption,
adsorption, condensation and rectification;
UNIT III 12
ortho-para conversion of hydrogen. Adsorption equilibria; types of adsorbant; adsorption/desorption
cycles; PSA, TSA; steady state and dynamic adsorption; concept of break point and mass transfer
zone;
UNIT IV 12
Design of fixed bed adsorption system for gas separation and purification. Phase equilibria and phase
rule; equilibrium stage operation; X-Y, T-X and H-X diagrams and their use;
UNIT V 12
Design of rectification columns; different tray assemblies; types of column assemblies for cryogenic
rectification; salient features of large scale gas separation.
Total hrs: 60
Reference:
1.Heat transfer at Low temperatures, 1975 by W.Frost
2.Cryogenic Systems, by R. Barron 1966.
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 7
MCEE 04 COMPUTATIONAL FLUID DYNAMICS 3 1 0 4
UNIT I 12
Continuum hypothesis, Lagrangian and Eulerian formulation, Governing equations-
continuity equation, momentum equation, energy equation, boundary conditions-
classification, initial and boundary value problems-Finite difference schemes-forward,
central and backward difference, basics of Finite volume schemes, Implicit and explicit
approaches.
UNIT II 12
FDM for Steady one-dimensional conduction, Two and Three dimensional steady
state problems, Transient one-dimensional problem, Two-dimensional Transient
Problems, Finite Volume formulation for 1D heat transfer. Uniform and
non-uniform Grids, Numerical Errors, Grid Independence Test.
UNIT III 12
Governing Equations, Stream Function – Verticity method, Determination of
pressure for viscous flow, SIMPLE Procedure of Patankar and spalding,
Computation of Boundary layer flow, Finite difference approach, Unstructured
Grids for Viscous Flows.
UNIT IV 12
Steady One-Dimensional and Two-Dimensional Convection – Diffusion, Unsteady one-
dimensional convection – Diffusion, Unsteady two-dimensional convection – Diffusion –
Introduction to finite element method – Solution of steady one dimensional heat
conduction by FEM – Incompressible flow – Simulation by FEM.
UNIT V 12
Turbulence, Effect of Turbulence and time averaged Navier Stokes Equation, Algebraic
Models – One equation model, K - Models, K-W model, Algebric stress model, Reynolds
stress equation model, Standard and High and Low Reynolds number models, Prediction of
fluid flow and heat transfer using standard codes.
Total hrs: 60
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 8
REFERENCES
1.Muralidhar, K., and Sundararajan, T., “Computational Fluid Flow and Heat Transfer”,
Narosa Publishing House, New Delhi, 1995.
2.Ghoshdasdidar, P.S., “Computer Simulation of flow and heat transfer” Tata McGraw-
Hill Publishing Company Ltd., 1998.
3.Subas, V.Patankar “Numerical heat transfer fluid flow”, Hemisphere Publishing
corporation 1980.
4.Taylor, C and Hughes, J.B. “Finite Element Programming of the Navier Stock
Equation”, Pineridge Press Limited, U.K
5.Anderson, D.A., Tannehill, J.I., and Pletcher, R.H., “Computational fluid Mechanics and
Heat Transfer “ Hemisphere Publishing Corporation, Newyork, USA,.
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 9
MCE 05 SEMICONDUCTOR DEVICES AND MODELING 3-0-0-3
UNIT I 9
Integrated circuits diodes and transistors; Current-voltage characteristics;
UNIT II 9
Ebers-Moll model and Gummel-Poon model of bipolar transistors; current gain;
UNIT III 9
Early effect and high level injection; 2-D effects; transient parameters; MOSFETs;
UNIT IV 9
Analysis of MOSFET parameters; short channel and narrow width effects; hot electron effects;
UNIT V 9
MOSFET models; JFET and MESFETs; Modulation doped FETs; HEMTs; Heterojunctions and
HBTs; microwave and optonic devices;
Total hrs: 45
Reference:
1. Semi conductor Device fundamendals by Robert F.Pierret
2. Principles of Semiconducor Devices by Bart Van Zeghbroech
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 10
MCE 06 CRYOFUEL SYSTEMS 3-0-0-3
UNIT I 9
Properties of Hydrocarbon Mixtures-equations of state, law of corresponding states, transport
properties.
UNIT II 9
Liquefied Petroleum Gas - properties, production and storage. Natural Gas-composition, source and
pretreatment.
UNIT III 9
Liquefaction of natural gas - simple cascade, mixed refrigerant and turbine expansion cycles,
UNIT IV 9
Ocean transport of LNG membrane and self-supporting tanks. Storage of LNG. Applications of NG
and LNG and safety aspects; Hydrogen - properties, production and pretreatment
UNIT V 9
Liquefaction of hydrogen - Linde, Claude and helium - hydrogen condensing cycles, Ortho-para
conversion. Storage and handling of liquefied hydrogen - applications of hydrogen, and its safety.
Total hrs: 45
Reference:
1. Cryogenic Systems, by R. Barron 1966.
2. R.B.Scott, Crogenic Engineering, 1959
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 11
SEMESTER II
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 12
MCE07 FINITE ELEMENT ANALYSIS 3 1 0 4
UNIT I INTRODUCTION 12
Basic concepts of finite element method. Steps involved in FEM. Solution of Boundary value
problem - Integral formulation for numerical solution - Variational method - Collocation method –
Sub domain method - Galeriken method - Least square method - Minimum total potential energy
formulation.
UNIT II 1D ELEMENTS 12
Use of bar and beam elements in structural analysis. Bar Element – Stiffness matrix formulation by
direct and polynomial methods. Boundary condition and assemblage concepts. Beam element
characteristics matrix. Global, local, natural coordinates - Numerical Integration.
UNIT III 2D ELEMENTS 12
Rectangular elements - Quadratic quadrilateral elements - Linear Triangular elements - 2D elements
applications for plane stress, plane strain and axi-symmetric problems. Numerical integration
schemes. Iso Parametric elements
UNIT IV APPLICATION OF FEM 12
1D & 2D problems in Solid mechanics, fluid mechanics and heat transfer by conduction and
convection. Torsion of non circular shaft - axisymmetric problem - acoustic vibration. Dynamics
problems representation in FE.
UNIT V FIELD PROBLEM 12
Case Studies like Structural analysis of Chassis Frame, Heat transfer analysis of piston, fins,
Whirling speed of propeller shaft, contact analysis of gears, modal analysis of suspension system etc.
FE software package review.
Total hrs: 60
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 13
TEXT BOOK:
1. Segerlind,L.J., Applied Finite Element Analysis, Second Edition, John Wiley and Sons Inc.,
New York, 1984
2. Robert D. Cook, David S. Malkus, Michael E. Plesha, Robert J. Witt, “Concepts and
applications of finite element analysis”, 4th
edition, John Wiley & Sons, 2007.
REFERENCES
1. Krishnamurthy, C.S., Finite Element Analysis, Tata McGraw Hill, 1987.
2. Ramamurthi,V., Computer Aided Design in Mechanical Engineering, Tata McGraw Hill,
1987.
3. Bathe,K.J. and Wilson,E.L., Numerical methods in finite element analysis, Prentice Hall of
India Ltd., 1983.
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 14
MCE08 COMPUTER AIDED DESIGN OF CRYOGENIC PROCESS PLANTS 3-0-0-3
UNIT I 9
Introduction to computer aided design; simulation, design and optimization. Sequential modular
simultaneous solution method.
UNIT II 9
Simulation of thermal systems. Thermodynamics and transport properties of Cryogenic fluids,
equations of state, vapour - liquid equilibrium.
UNIT III 9
MIPROPS, DDMIX AND ALLPROPS physical properties programs. Cryogenic process plants,
development of mass, momentum and energy balance equations.
UNIT V 9
Introduction to general and special purpose process plant simulators. Simulation of liquefiers and
refrigerators based on Line, Claude and mixed refrigerant cycles using available process simulators.
UNIT V 9
Computer aided design of heat exchangers, expansion turbines and distillation columns.
Total hrs: 45
Reference:
1. Computer Aided Chemical Engineering By L.M. Rose
2. Plant Design and economics for Chemical Engineers Max Stone Peters, Klaus D.
Timmerhaus, Ronald Emmett West, Ronald E. West
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 15
MCE09 CRYO HEAT TRANSFER 3-1-0-4
UNIT I Convective Heat Transfer 12
Generalised solution of steady and unsteady conduction equations: Heat transfer through composites
and materials of variable thermal properties: Analytical and numerical methods.
UNIT II Conductive Heat Transfer Problem 12
Insulation, Heat leakage and Cooldown looses; Fins and Heat Exchangers.
UNIT III Convective Heat Transfer 12
Analysis and Theories; Evalution of heat transfer and friction coefficients; Reynolds analogy,
Turbulent and Laminer flow; Forced convection, Natural convection and near critical heat transfer
regions.
UNIT IV Two Phase Phenomena 12
Physical description, Pool boiling, Critical heat flux, Condensation, Evaporation, Pressure drop of
Two Phase fluid, Forced convection with Two Phase flow, Super fluid heat transfer.
UNIT V Radiation 12
Physics, Properties, Shape factor, Radiative Exchange.
Total hrs: 60
Reference:
1. Cryo Heat Transfer by Randall Barron.
2. Cryogenic Technology & Applications A.R.Jha
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 16
MCE10 GAS TURBINES AND JET PROPULSION 3-1-0-4
UNIT I 12
Thermodynamic cycle analysis of gas turbines; open and closed cycles. Axial flow turbines; blade
diagrams and design of blading, performance characteristics.
UNIT II 12
Centrifugal and axial flow compressors, blowers and fans. Theory and design of impellers and
blading.
UNIT III 12
Matching of turbines and compressors. Fuels and combustion, effect of combustion chamber design
and exhaust on performance.
UNIT IV 12
Basic principles and methods of heat recovery. Thermodynamic cycle analysis and efficiencies of
propulsive devices.Thrust equation, classification and comparison of ram jets, turbojets, pulse jets
and rockets.
UNIT V 12
Performance of turbo-prop, turbo-jet and turbo-fan engines. Augmentation of thrust.
Total hrs: 60
Referance:
1. Gas Dynamics & Jet Propulsion by S.L.Soma Sundaram
2. Gas Turbines & Jet Propulsion by G.Geoffrey & Smith
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 17
MCE11 DESIGN OF CRYO. EQUIPMENT AND ACCESSORIES 3-1-0-4
UNIT I 12
Mechanical and Thermal Properties of engineering materials at low temperatures; Tube, Plate and
shell stresses, thermal stresses; safety requirements and codes of practice.
UNIT II 12
Components of Cryogenic refrigerators and liquefiers; Compressors: types, construction and
characteristics.
UNIT III 12
Expansion machines: characteristics of reciprocating and turbine expanders; Heat exchangers and
regenerators theory, types, design approaches and selection criteria, Computer aided design.
UNIT IV 12
Design of Cryogenic process plants; process charts of existing industrial systems; Stirling and G.M.
cycle based cryorefrigeration.
UNIT V 12
Production of industrial gases: nitrogen, oxygen, argon, helium, hydrogen, acetylene and nitrous
oxide. Instrumentation and control in cryogenic systems.
Total hrs: 60
Reference:
1. Hand book of cryogenic Engineering by J.G.Weisend
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 18
\MCE12 CRYO. ENGINEERING LAB 0-0-3-2
1. Experiments on Heat transfer.
2. Experiments on Mass transfer.
3. Experiments on Compression and expansion
4. Experiments on machinery and components of Cryogenic Systems
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 19
SEMESTER - III
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 20
MCE 13 PRACTICAL TRAINING 0 0 3 2
Students are supposed to undergo practical training in cryogenic fields for 15 days and submit a
report on the training. Viva voce exam will be conducted at the end of the semester to evaluate the
knowledge gained during the training.
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 21
MCE 14 PROJECT PHASE-I 0 0 10 5
Students should select the area of the project and do extensive literature survey and identify the
problem of the project. Should make a review paper based on literature survey and present a paper in
National/International conference. At the end of the semester a report has to be prepared and
submitted for viva voce examination.
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 22
SEMESTER IV
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 23
MCE 15 PROJECT WORK 0 0 30 15
Surdents are supposed to carry out a Project work in the inter- disciplinary areas like medicine,
biotechnology, instrumentation Engineering. The Project Work will bé for a period of 6months and
at the end of the semester they have to submit the Project report. The projects useful to the society
are encouraged.
Project ViaVoce exam will be conducted at the end of the semester with external and internal
examiners..
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 24
LIST OF ELECTIVES
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 25
MCEE 01 CRYO BIOLOGY 3-0-0-3
Unit I 9
Introduction
Low Temperatures in Nature Cryomedicine: Cryosurgery and Cryopreservation.
Lyophillization Cryofixation. Destruction of Biological Tissues.
Forensic Medicine Food Industry Numerical Simulation of Cryoaction
Unit II 9
Ice Formation in Biological Medium
Amorphous Ice, Water, Biological water. Crystallization in Heterogeneous Media
Unit III 9
Biological Effects of Low Temperatures
Processes in cells Under Hypothermia Antifreeze Proteins (AFPs), Ice Nucleating Agents
(INAs) Protein Denaturation Membrane Behavior, Cells in Aqueous Solutions Cell Dehydration
Intracellular Ice Cryoprotective Agents, Cell Interaction with Crystallization Front
Unit IV 9
Heat Transfer in Biological Tissues
Heat Transfer in Living Tissues, Continuum Models, Vascular Models, temperature
Fluctuations in Living Tissues
Unit V 9
Mechanical Stress in Frozen Biological Objects
Stress in Frozen Tissues, Stress in Vitrified Biological Objects
Total hrs: 45
Reference:
1. Fundamentals of Cryobiology by Zhmakin, Alexander I
2. Cherie Winner ,Lener Publishing group 2005- ISBN-10,ISBN-13
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 26
MCEE 02 MAN POWER ECONOMICS 3-0-0-3
UNIT I 9
Manpower problems and the Scope of Manpower Economics; Manpower and Human Capital
Formation; Employment and Manpower Utilization.
UNIT II 9
Determination of the General Level of Employment, Supply and Demand for Labour, Wage
Determination, Definition and Structure of Labour Markets, Labour Productivity - Concepts and
Measurement; Concepts and Patterns of Unemployment and Underemployment.
UNIT III 9
Emergence of Education as a Work Prerequisite; Returns to Investment in Education; Role of
Apprenticeship and on-the-job Training.
UNIT IV 9
Meaning and Importance of Manpower Planning at the Macro and the Micro Level; Forecasting and
Auditing of Manpower; Quantitative and Qualitative Techniques of Manpower Planning.
UNIT V 9
Manpower Planning and Total Quality Management; Comparative Manpower Planning and
Development Policies of a few selected countries under Competitive Environment.
Total hrs: 45
Reference :
1. Man power economics by Edward B.Jakubauskas , Neil A.Palomba.(1973)
2. Man power economics by Lowell E. Gallaway
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 27
MCEE 03 ROBOTICS AND SENSORS 3 0 0 3
UNIT I INTRODUCTION 9
Basic concepts-Robot anatomy-robot configurations-Basic Robot motions-Types of drives-
Applications-
Material Handling-Processing-Assembly and Inspection -Safety considerations.
UNIT II TRANSFORMATIONS AND KINEMATICS 9
Vector operations-Translational transformations and Rotational transformations-Properties of
transformation
Matrices-Homogeneous transformations and Manipulator-Forward solution-Inverse solution
UNIT III CONTROLS AND END EFFECTORS 9
Control system concepts-Analysis-control of joints-Adaptive and optimal control-End effectors-
Classification-Mechanical-Magnetic-Vacuum-Adhesive-Drive systems-Force analysis and Gripper
design
UNIT IV ROBOT PROGRAMMING 6
Methods -Languages-Computer control and Robot Software-VAL system and Language
UNIT V SENSORY DEVICES 12
Non-optical and optical position sensors-Velocity and Acceleration-Range-Proximity-touch-Slip-
Force-
Torque-Machine vision-Image components-Representation - Hardware-Picture coding-Object
recognition and
Categorization-Software consideration- Case Studies
Total hrs: 45
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 28
REFERENCE:
1. Fu K.S., Gonzalez R.C.., Lee C.S.G., "Robotics control, sensing, vision, and Intelligence",
McGraw Hill Book Co.,,1987
2. Klafter R.D., Cmielewski T.A. and Negin M ., "Robot Engineering An Integrated approach",
Prentice Hall of India, New Delhi, 1994
3. Deb S.R., "Robotics Technology and Flexible Automation", Tata McGraw Hill Publishing Co.,
Ltd., 1994
4. Craig J.J., "Introduction to Robotics Mechanics and Control", Addison Wesley, 1999
5. Groover M.P., "Industrial robotics Technology, programming and applications", McGraw Hill
Book Co., 1995.
WEB REFERENCE:
1. http://www.robotics.com
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 29
MCEE 04 BIO MEDICAL EQUIPMENTS & DEVICES 3 0 0 3
UNIT I CARDIAC CARE UNITS 6
Pace makers – different types, batteries for pace makers, AC defibrillators, asynchronous and
synchronous DC defibrillators, patient monitoring system.
UNIT II NEUROLOGICAL EQUIPMENTS 10
Stereo toxic UNIT, depth recording system, dot scanners, transcutaneous nerve stimulator, anesthesia
Monitor, EEG controlled Anesthesia, Bio Feedback Equipments, Spinal Reflex Measurements, Front
end devices for all Biomedical Equipments
UNIT III DIATHERMY AND STIMULATOR 10
Depth of penetration and physiological effects of H.F. radiation, short wave, Ultrasonics, and Micro
Wave Diathermy, Surgical Diathermy, Physiological effects of stimulation, Galvanic, Farradical
Surged types, Interfrantial Therapy.
UNIT IV BIO-TELEMETRY 8
Principal, frequency selection for Telemetry, radio pills, multiplexing and tracking techniques,
Telestimulation
UNIT V RECENT TRENDS 6
Principles of Thermography, detecting circuits, its application in medicine, principles of Cryogenic
Techniques, its application in medicine, Principles of Fiber optic cable, Endoscopy, Laproscopy,
Opthaimic Equipments.
UNIT VI ELECTRICAL SAFETY 5
Micro and macro shock, sources of shock, monitoring and interrupting circuit from leakage current,
Earthing scheme.
Total hrs: 45
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 30
REFERENCES:
1. Albert M. Cook and Webster J.G., Therapeutic Medical Devices, Prentice Hall Inc., New
Jersery, 1982.
2. Feinberg B.N. Applied Clinical Engineering, Prentice Hall Inc., Engiewood Cliffs, New
Jersery, 1986
3. Khandpur R.S. Handbook of Biomedical Instrumentation. Tata McGraw Hill Publishing
company, New Delhi 1999.
4. Jacobson B. and Webster. J.G. Medicine and Clinical engineering, Prentice Hall of India,
New Delhi, 1999
5. Leslie Cromwell, etal., Biomedical Instrumentation and measurements, Prentice Hall India,
New Delhi, 2000
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 31
MCEE 05 CRYO TISSUE ENGINEERING 3 0 0 3
UNIT I INTRODUCTION 9
Introduction to tissue engineering: Basic definition; current scope of development; use in
therapeutics and in vitro testing, Structure and organization of tissue; epithelial, connective;
vascularity, lymph. Basic developmental biology.
Transport Properties of Tissues I: Introduction to mass transfer, Diffusion of simple metabolites,
Diffusion & reaction, Diffusion & reaction of proteins, General aspects of cells in culture; Transport
limits on 3D cultures.
UNIT II CELL MATRIX & INTERACTIONS 10
Cell – Matrix & Cell –Cell Interactions, Cells in culture on different kinds of matrix – different cell
types, staining, differential cell adhesion & tissue organization, Hormone& Growth Factor Signaling
I, Hormone & Growth Factor Signaling II, Growth factor delivery in tissue engineering, Quantitative
analysis of receptor- legend binding
UNIT III CELL GROWTH 10
Applications of growth factors: VEGF / angiogenesis, Scaffolds & tissue engineering- Basic
properties, Scaffolds, LAB DEMO: Scaffolds, Basic transplantation immunology, Stem Cells
I:Introduction, Hematopoietic, Stem Cells II: ES cells, Recitation: Cell surface markers, FACS
analysis, repopulation experiments, Stem cells III: Jainism paper, Stem Cells IV: Blood from ES
Cells paper, Basic wound healing, Stem cells & bone
UNIT IV CELL MIGRATION 9
Cell Migration I, Cell Migration II,Control of cell migration in tissue engineering, Case study of
multiple approaches: Introduction to liver path physiology.
UNIT V TRANSPLANTION 7
Cell transplantation for liver tissue engineering, In vitro organogenesis Physiological models, case
studies.
Total hrs: 45
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 32
Reference
1. J B Park, Biomaterials –Science and Engineering, Plenum Press, 1984
2. Sujata V. Bhat, Biomaterials, Narosa Publishing House, 2002
3. Jonathan Black, Biological Performance of materials, Marcel Decker, 1981
4. C.P.Sharma & M.Szycher, Blood compatible materials and devices, Technomic publishing
Co.Ltd.,1991
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 33
MCEE 06 BIO INFORMATICS 3-0-0-3
Unit I: 9
Sequence Databases and Information Retrieval: Nucleotide Sequence Databases; GenBank, EMBL,
DDBJ, all as part of INSDC; accession numbers & annotations, Medical Databases
9
Unit II.
Pairwise Sequence Comparisons: biology of homology, PAM & BLOSSUM scoring matrices, global
& local alignment algorithms, statisical significance of pairwise alignments.
Unit III. 9
BLAST, FASTA and Advanced BLAST: Database searching, FASTA algorithm, BLAST
ALGORITHM, PSI BLAST, STATISTICAL SIGNIFICANCE OF DATABASE SEARCHES
9
Unit IV:
Protein Sequence and Structure Analyses : 4 essential perspectives on proteins: (1) domains
and motifs, (2) physical properties, (3) protein localization, (4) protein function. Gene Ontology for
these perspectives in action; proteomics - methods, practices, databases introduction to protein
structure and structural genomics; principles of protein structure & protein folding - X-ray
crystallography and NMR - the PDB, RCSB, SCOP, CATH, DALI, FSSP & others.
Unit V. 9
MSA's or Multiple Sequence Alignments: Hierarchical and non-hierarchical Methods -
MSAs by PSI-BLAST , Tools for MSAs, 3D-PSSM Protein Fold Recognition (Threading) Server:
Introduction to Molecular Evolution, Tree nomenclature and structure; the 4 stages of Phylogenetic
Analysis, tree-building methods, NJ, MP, ML, tree-evaluation methods, the Bootstrap,
Phylogenetics: Introduction to the basics, Models, Assumptions, & Interpretations, How to construct
a Tree in 4 steps; the differences, between Parsimony, Distance, and Likelihood.
Total hrs: 45
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 34
TEXTBOOKS
Bioinformatics and Functional Genomics by Jonathan Pevsner (2003), Wiley-Liss
Bioinfbook.org - Website dedicated to the text with updated URLs
REFERENCES
1. An Introduction to Bioinformatics Algorithms by N.C. Jones & P.A. Pevzner (2004), MIT
Press
2. Phylogenetic Trees Made Easy: A How-To Manual, Second Edition by Barry G. Hall (2004),
Sinauer Associates, Inc.
3. Bioinformatics and Molecular Evolution by Paul G. Higgs and Teresa K. Attwood (2005),
Blackwell Publishers
4. Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins, edited by Baxevanis
& Oulette (2005), Wiley-Interscience
5. Fundamental Concepts of Bioinformatics by D.E. Krane & M.L. Raymer (2003), Benjamin
Cummings
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 35
MCEE07 CRYO PHYSICS 3-0-0-3
UNIT-I 9
Introduction to quantum mechanics, the electronic structure of atoms, Molecular orbits and
Covalent bonds, Molecular interaction, Stereochemistry and Chirality, Thermodynamics-Entropy,
Enthalpy, Free energy of a system, Chemical Potential, Oxidation-Reduction Potential,
Radioactivity-rate of radioactivity decay and application of radio isotopes.
UNIT-II 9
Macromolecular structure-Introduction, Chemical structure of nucleic acids, the double Helical
structure of DNA,DNA Super coiling and unusual DNA Structures, the Structure of transfer RNA,
Protein Structure-Amino acids, Primary structure of proteins, Peptide Bond and Secondary
Structures of Proteins, Tertiary Structures, Quaternary Structure.
UNIT-III 9
Introduction-Free Energy, Coupled reaction, Photosynthesis-Photsystem I, Photosystem II,
Photophosphorylation and Carbon fixation. Energy Conservation pathways, Oxidation, Glycolysis
Kerbs cycle, Respiratory chain, Membrane transport-active transport, Chemi-Osmotic theory-Passive
Transport.
UNIT-IV 9
Separationtechniques-Chromatography-ColumnChromatography,Thinlayer Chromatography, Paper
Chromatography, Adsorption Chromatography, partition
Chromatography, Gas Liquid Chromatography, Ion-exchange Chromatography,
Molecular Exclusion Chromatography, Affinity Chromatography.
UNIT-V 9
Spectroscopy-Introduction, Ultraviolet Spectroscopy, Fluorescence spectroscopy
Infrared Spectroscopy, Raman Spectroscopy, Electron spin resonance,
NMR-Introduction, Basic Principles of NMR,NMR Application in Biochemistry, Biophysics and
Medicine.
Total hrs: 45
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 36
Text Books
1. Vasantha Pattabhi, N.Gautham . Biophyiscs
2. G.R.Chatwal, Edited by Madhu Arora.Himalaya Publishing House. Biophysics
3. Rodney Cotterill, John Wiley & sons, LTD. Biophysics an Introduction
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 37
MCEE08 QUANTITATIVE METHODS 3-0-0-3
UNIT1 9
Statistical population, sample from population, random sample, Tabular and graphical
presentation, Mean and standard deviation of group and ungrouped data. Measures of central
tendency, measures of dispersion, measures of skewness (using calculators) , Correlations (product-
moment coefficient, Spearman’s rank coefficient) and regression (linear regression, curve fitting)
UNIT2. 9
Data presentation (tables/figures): 1-D and 2-D bar charts, pie diagrams, graphs (using computer
software packages), Statistical distributions: fitting discrete uniform, binomial, Poisson and normal
probability distributions to given data 3
UNIT3. 9
Testing of hypothesis, Test of significance, test for proportion, means and standard deviations, F and
t test, chi-square test for goodness 10of fit, Theory of errors, errors and residuals, precision, measure
of precision, probable error of function, rejection of observation
UNIT4. 9
Methods of averages and least squares, Correlation and linear regression, associated test of
significance, Analysis of variance for one and two way classification.
UNIT5 9
Design of experiments, Sampling, randomization, replication, local control, completely randomized
and randomized block design. Nonparametric tests.
Total hrs: 45
Text Book
1.Statistical Methods in biology by Norman T.J. Bailey (3rd
Edition), Cambridge University Press
(1995)
2.Biostatistics How it works, Steve Selvin, Pearson Education, (2004)
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 38
MCEE 09 SUPERCONDUCTING MATERIALS, MAGNETS AND DEVICES 3-0-0-3
UNIT I 9
Review of critical current densities and critical magnetic fields of type II superconductors;
UNIT II 9
Magneto-thermal instabilities in type II superconductors; Concept of flux pinning
mechanisms.
UNIT III 9
Techniques of preparation of superconducting materials of type Nb3Sn, V3Ga and ceramic
superconductors in the form of wires and tapes; Stabilization Criterion.
UNIT IV 9
Superconducting coil devices: Superconducting magnets, persistent current switches;
UNIT V 9
Basic concepts of superconducting bearings, motors and energy storage. Superconducting
thin film devices: negative resistance devices. Weak link devices including SQUIDS and its
applications; infrared dectors
Total hrs: 45
Reference:
1. Macroscopic theory of Superconductivity (Vol 1),1950 by Fritz London
2. Macroscopic theory of Superfuilid Helium (Vol 2),1954 by Fritz London
3. Superfluidity & Superconductivity, 1974 by Dr.Tilley & J.Tilley
M.Tech cryogenic Engineering
Department of Mechanical Engineering Dr. M.G.R. Educational and Research Institute University 39
MCEE 10 VACUUM TECHNIQUES 3-0-0-3
UNIT I 9
Review of physical principles of vacuum - flow regimes: conductance and throughput Viscous and
molecular flow calculations for typical cases
UNIT II 9
Physico chemical phenomena in vacuum techniques; production and measurement of high and ultra
high vacuum
UNIT III 9
Leak detecting procedures - Materials and components for vacuum and high vacuum systems.
UNIT IV 9
Applications of vacuum Technology; Ultra high vacuum in space simulation and nuclear physics.
UNIT V 9
High vacuum coating units; Super insulated vacuum containers for storage of cryogenic fluids.
Total hrs: 45
Reference:
1. Vacuum Technology by A.Roth, North Holland.
2. Introduction to Vacuum Technology David M. Hata
3. Basic Vacuum Technology by A.Chambars
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