Supplemental Figure 2 Inhibition of FGFR3 function diminishes MMP-1 and MMP-10 mRNA and protein expression in UMUC-14 bladder cancer cells. (A) FGFR3 knockdown by siRNA reduces mRNA level of MMP-1 and MMP-10. (B) A specific anti-FGFR3 blocking antibody, R3Mab, reduces mRNA level of MMP-1 and MMP-10. Cells were treated with 15 ug/mLof R3Mab for 24h, and total RNA was isolated for Taqman analysis.

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