8/3/2019 PD Solute Clearance
1/65
_J RFESZC BEC@^@KBCI`+Kmr`kZ+I`k`smr%^K%I@K%B^KB
Nf`~jIcinc~%^CK@_
8/3/2019 PD Solute Clearance
2/65
Zhc_c~mzfkcsi
LC]_FMKZR Rc~fr`eicin~`kctmzh`~c`csmw`eckzzfnfj}rs~g`bc`~c`%M+c+0zf>icz~cr>
8?#mrwmrbc~`epc~mzfkcsi`kj
dczrmzrw`rbse`~rsppe}wm`zhcicrckzc~mb`~zc~mcr`kjpf~z`ewcmkr
>?#mrp`~mcz`epc~mzfkcsi`kjdczrmzrw`rbse`~rsppe}wm`
`~zc~mcr`kjwcmkrfg`njfimk`et`ee`kjh`rif~cmipf~z`kzzh`kwmrbc~`epc~mzfkcsi
E}iph`zmbj~`mk`dcfgpc~mzfkc`eb`wmz}mri`mke}wm`
jm`ph~`di`zmbrzfi`z`
8/3/2019 PD Solute Clearance
3/65
Zhc_c~mzfkcsi
LC]_FMKZR _c~mzfkc`eb`wmz}mremkcjn}`icrfzhcem`eifkfe`}c~thmbhp~fjsbcr`esn~mb`zmkdgesmj
Skjc~zhcicrfzhcemsimr`dce)emlcmkzc~rzmzmsibfkz`mkmkdbfkkcbzmwczmrrscgmn~cr%b`pmee`~mcr`kje}iph`zmbr
Zhccggcbzmwcrs~g`bc`~c`mrb~mzmb`egf~jm`e}rmr`kjjcpckjrfkzhcw`rbse`~mz}fgzhcpc~mzfkcsi+
8/3/2019 PD Solute Clearance
4/65
ZhcKf~i`e_c~mzfkcsi
_c~mzfkc`e w`rbse`zs~c
Icrfzhcem`e bcee ifkfe`}c~
Mkzc~rzmzmsi
8/3/2019 PD Solute Clearance
5/65
ZhcKf~i`e_c~mzfkc`eIcin~`kc
8/3/2019 PD Solute Clearance
6/65
Z~`krgc~ n} jmggsrmfk mr zhc p`rrmwc z~`krgc~ fg rfeszcr `b~frr zhcicin~`kc% tmzhfsz zhc p`rr`dc fg rfewckz (t`zc~-+
0
>
0 ) ^cj neffj bcee> ) N`bzc~m`
Rfjmsi
_fz`rrmsi
Bhef~mjc
Nmb`~nfk`zc S~c`
B~c`zmkmkc
S~mb `bmj
Ncz` >)i(Rfeszc _I;3???-
Neffj
Jm`e}r`zc
Icin~`kc
Jmggsrmfk
8/3/2019 PD Solute Clearance
7/65
s Icin~`kcr Rs~g`bc `~c`% z}pc% zhmblkcrr
s Neffj gmei zhmblkcrrs Jm`e}r`zc geft bfkgmds~`zmfk
s Bfkbckz~`zmfk d~`jmckzs Rmqc fg rfeszc
s Sez~`gmez~`zmfk
s Zcipc~`zs~c fg jm`e}r`zcs Pn ) Neffj geft ~`zcs Pj ) Jm`e}r`zc geft ~`zcs Zmic
G`bzf~r cggcbzmkd Jmggsrmfk
8/3/2019 PD Solute Clearance
8/65
s Icin~`kcr Rs~g`bc `~c`% z}pc% zhmblkcrr
s Neffj gmei zhmblkcrrs Jm`e}r`zc geft bfkgmds~`zmfk
s Bfkbckz~`zmfk d~`jmckzs Rmqc fg rfeszc
s Sez~`gmez~`zmfk
s Zcipc~`zs~c fg jm`e}r`zcs Pn ) Neffj geft ~`zcs Pj ) Jm`e}r`zc geft ~`zcs Zmic
G`bzf~r ~cecw`kz zf _J
8/3/2019 PD Solute Clearance
9/65
Rsnrz`kbc B@_J BB_J KM_J HJ
S~c`(ife tz 7?-
34 34 38 0>7
B~c`zmkmkc(if tz 002
:4 :4 27 0??
Wmz N0>(ife tz 023>-
2: 2? 04 2?,
Tccle} pe`ri` bec`~`kbcr E&tccl
8/3/2019 PD Solute Clearance
10/65
2_f~cIfjce
0)E`~dcpf~crf~becgzr(>?):?ki-gf~z~`krpf~zfge`~dcifecbsecrrsbh`rp~fzcmkr+
>)Ri`eepf~cr(:)7ki-1if~czh`kfzhc~r`kj~crpfkrmnecgf~z~`krpf~zfgri`eerfeszcrrsbh`rs~c`%b~c`zmkmk%K``kjL
2)Z~`krbceese`~(sez~`pf~cr-tmzhjm`iczc~ecrr
zh`k?+8kizh`z~crpfkrmnecgf~t`zc~z~`krpf~z`kj`~crmime`~zf`s`pf~mkr
!Rmcwmkdmrmkjsbcjn}sez~`pf~cr
8/3/2019 PD Solute Clearance
11/65
2_f~cIfjce
bcee askbzmfkr 9 e`~dc pf~cr
{>3?{:?
5 3
t`zc~ ifecbsecr wm` sez~`pf~c
8/3/2019 PD Solute Clearance
12/65
8/3/2019 PD Solute Clearance
13/65
G`bzf~r zh`z jcemwc~ bec`~`kbc
Zfz`e wfesic
w Wfesic pc~ cxbh`kdc
w Ksinc~ fg cxbh`kdcr
Jtcee zmic
G`bzf~r j~mwmkd bec`~`kbc ~csm~cickzr
S~c` dckc~`zmfk(jmcz% tcmdhz% icz`nfemb ~`zc-
^crmjs`e ~ck`e bec`~`kbc(lmjkc} gskbzmfk-
S+G+ ~`zc (rfeszmfk zfkmbmz}% gesmj mkz`lc-
_c~mzfkc`e icin~`kc (pc~ic`nmemz}-
Rfeszc Bec`~`kbc mk _J
8/3/2019 PD Solute Clearance
14/65
Ifwcickz fg t`zc~ g~fi `k `~c` fg eft rfeszcbfkbckz~`zmfk zf `k `~c` fg hmdh rfeszc bfkbckz~`zmfk+
Neffj>8? ) >=3iFri&E
Jm`e}rmr rfeszmfk2:4) :87iFri&E
T`zc~
Rfeszc
T`zc~
Rfeszc
Frifrmr
8/3/2019 PD Solute Clearance
15/65
Ckjfzhcemsi
B`pmee`~mcr
Icrfzhcemsi
Ri`ee rfeszcr
Desbfrc
I`b~f ifecbsecr
B~}rz`eefmjfrifrmr
Bfeefmjfrifrmr
T`zc~
Mkzc~rzmzmsi
_c~mzfkc`e zmrrsc e`}c~
Jm`e}r`zc
_`zht`}r gf~ _c~mzfkc`e Z~`krpf~z
8/3/2019 PD Solute Clearance
16/65
Bec`~`kbc fg rfeszcr (n} jmggsrmfk `kjbfkwcbzmfk-
Gesmj ~cifw`e (z~`krb`pmee`~} SG gesmj`nrf~pzmfk-
_c~mzfkc`eZ~`krpf~z
>Bemkmb`eCkjpfmkzr
8/3/2019 PD Solute Clearance
17/65
Jmggsrmfk
Sez~`gmez~`zmfk
Gesmj @nrf~pzmfk
_c~mzfkc`eZ~`krpf~z
2Jmrzmkbz_~fbcrrcr
8/3/2019 PD Solute Clearance
18/65
Th`zH`ppckrtmzhRfeszc^cifw`e
Js~mkd`B@_JJtcee6Jmggsrmfkmr`z`i`xmisi%`kjs~c``kjb~c`zmkmkccsmemn~`zmfk`~cg`rzcrz%mkzhcgm~rzhfs~nszncbficreftc~`rzhcd~`jmckzecrrfkrtmzhzmic
N}:hfs~r%s~c`mr;=?#`kjb~c`zmkc;73#csmemn~`zcjmkifrzp`zmckzr
Jm`e}r`zczfpe`ri`(J&_-~`zmfric`rs~cjcd~ccfgcsmemn~`zmfk`z`dmwckjtceezmic(c+d+J&_S~c`%J&_B~c`zmkc-
8/3/2019 PD Solute Clearance
19/65
Jmggsrmfkmrkfzjcpckjckzzfpc~mzfkc`eneffjgeft+
Jmggsrmfkmrkfzjcpckjckzzfpc~mzfkc`ers~g`bc`~c`nszzfw`rbse`~mz}+
Jmggsrmfkmr`erfjcpckjckzzffrifzmbd~`jmckz`kj
rmqcfgrfeszcr+
Zhcifrzmipf~z`kzg`bzf~thmbhmrifjmgm`necmr
jm`e}r`zcgesmjwfesic`kjfrife`emz}+
8/3/2019 PD Solute Clearance
20/65
_c~mzfkc`eCsmemn~msiZcrz
>emzc~rfg>+3#jcxz~frc`kjic`rs~cickzfgjm`e}r`zcdesbfrc`kjs~c``zzhczmicr1?%>%:`kjpe`ri`desbfrc`kjs~c``zzhczmicr1?%>%:
Cwc~}p`zmckzi`}nc1
0)hmdhz~`krpf~zc~
>)hmdh`wc~`dcz~`krpf~zc~2)eft`wc~`dcz~`krpf~zc~
:)eftz~`krpf~zc~
8/3/2019 PD Solute Clearance
21/65
# _zr+ Icin~`kc
z}pc
:)H~ J&_
B~c`zmkmkc
Bh`~`bzc~mrzmbr
0?# Hmdh Wc~} cggmbmckz icin~`kcZ~`krpf~zr rfeszc smble}
Mkb~c`rcj desbfrc `nrf~pzmfk
I`} h`wc jmggmbsez} `bhmcwmkdsez~`gmez~`zmfk
@z ~mrl gf~ eft rc~si `ensimk
32# Hmdh
@wc~`dc?+73 ) +80 Cggmbmckz icin~`kc
Z~`krpf~zr rfeszc tcee
Sez~`gmezc~r tcee
20# Eft
@wc~`dc?+3? ) +7: Ecrr cggmbmckz icin~`kc
Z~`krpf~zr rfeszcr rficth`z refte}
Sez~`gmezc~r tcee
7# Eft ?+2: )+:= Mkcggmbmckz icin~`kcZ~`krpf~zr rfeszcr refte}
Jmggmbsez zf fnz`mk B~ Be thck kf~crmjs`e ~ck`e gskbzmfk
Sez~`gmezc~r wc~} tcee
8/3/2019 PD Solute Clearance
22/65
Desbfrc
?
?+0
?+>
?+2
?+:
?+3
?+7
?+4
?+8
?+=
0
? 0 > 2 :
Hfs~r
J&JF
B~c`zmkmkc
?
?+>
?+:
?+7
?+8
0
? 0 > 2 :
Hfs~r
J&_
Eft
Eft `wc
@wc
Hmdh `wc
Hmdh
_c~mzfkc`eCsmemn~msiZcrz
8/3/2019 PD Solute Clearance
23/65
I`xmimqc bfkbckz~`zmfk d~`jmckz
) If~c g~csckz cxbh`kdcr (c+d+% @_J-
) E`~dc~ jtcee wfesicr
Mkb~c`rc cggcbzmwc pc~mzfkc`e rs~g`bc `~c`
) E`~dc~ jtcee wfesicr
Jmggsrmfk
Hftzfmkb~c`rcmz6
8/3/2019 PD Solute Clearance
24/65
JmggsrmfkHft zf Mkb~c`rc Mz
I`xmimqc bfkbckz~`zmfk d~`jmckz
) If~c g~csckz cxbh`kdcr (c+d+% @_J-
) E`~dc~ jtcee wfesicr
Mkb~c`rc cggcbzmwc pc~mzfkc`e rs~g`bc `~c`
) E`~dc~ jtcee wfesicr
8/3/2019 PD Solute Clearance
25/65
_c~mzfkc`eGesmj@nrf~pzmfk
Fbbs~rjm~cbze}wm`e}iph`zmbr
@erf`nrf~pzmfkmkzfzmrrscrtmzhrsnrcsckz~cifw`ewm`e}iph`zmbr`kjb`pmee`~mcr
Jmggmbsezzfic`rs~cnszmr`nfsz0zf>ierpc~imkszc(>3?)3??iermk:hfs~r-
8/3/2019 PD Solute Clearance
26/65
KczSez~`gmez~`zmfk
KczSGmr`bzs`eSGimksrgesmj`nrf~pzmfk
c+d+0???ier>??ier98??ierKczSG
Bemkmb`ee}tcb`kfke}mkgesckbcKczSGn}1
`ezc~mkd zhc frifzmb d~`jmckz(c+d+g~fi0+27#zf>+>4#-%
bh`kdmkd zhc frifzmb `dckz(c+d+g~fidesbfrczfmbfjcxz~mk-
8/3/2019 PD Solute Clearance
27/65
Desbfrc
B`pmee`~}
_c~mzfkc`e Rp`bc
Mkzc~bceese`~1 ;=?#
Desbfrc z~`krpf~zc~icjm`zcj1 imkmi`e
_`zht`}rfgDesbfrcGeft
8/3/2019 PD Solute Clearance
28/65
NEFFJ
I
cin~`kc
_C^MZFKC@EJM@E]R@ZC
Icin~`kcIfjce
8/3/2019 PD Solute Clearance
29/65
Th`zH`ppckrzfGesmj^cifw`e
tmzh`>E:+>3#_JJtcee6Kfzc1M&_9Mkz~`pc~mzfkc`ef~mkrmjcpc~mzfkc`eb`wmz}
SGmri`xmi`e`zzhcrz`~zfgzhcjtcee%`pp~fx+03ie&imk
Mzsmble}ecrrfkr`rdesbfrcjmggsrcrfszfgzhcjm`e}r`zcmkzfzhcneffj`kj`rzhcSGjmeszcrzhcdesbfrc
M&_wfesicmkb~c`rcrskzme`nfsz2hfs~rthckSG~`zcg`eerzfcs`ezhcbfkrz`kzgesmj`nrf~pzmfk~`zcfg0)>ie&imk
@gzc~zhmr%zhcM&_wfesic~cjsbcrskzmemzmrecrrzh`k>E`gzc~8)0?hfs~r%ec`jmkdzfkczgesmj~czckzmfk
8/3/2019 PD Solute Clearance
30/65
Ri`ee Rfeszc Bec`~`kbcmk _J _`zmckzrBec`~`kbcmrzhcs`kzmz}fgpe`ri`g~fithmbhrfeszcmr
bec`~cjpc~skmzzmic
Mk_J1
;zfz`ebec`~`kbc9pc~mzfkc`e,~crmjs`e~ck`e
_c~mzfkc`ebec`~`kbcjcpckjrfk1
;jmggsrmfk,SGgesmj`nrf~pzmfk
`kjrfw`~mcrjs~mkdzhcbfs~rcfgzhcjtceepc~mfj
J`me}pc~mzfkc`ebec`~`kbc9
;j`me}jm`e}r`zcj~`mkwfesicxJ&_~`zmf
(gf~zhcrfeszcbfkbc~kcjfwc~zh`zj`}-
8/3/2019 PD Solute Clearance
31/65
Jczc~imk`kzr fg Bec`~`kbc
@bhmcwcj fk _J^crmjs`e ~ck`e gskbzmfk
Nfj} rmqc (Wfesic f~ Nfj} Rs~g`bc @~c`-
_c~mzfkc`e rfeszc z~`krpf~z ~`zc
Zhc p~crb~mpzmfk
8/3/2019 PD Solute Clearance
32/65
Th`z @nfsz _~fzcmk6
_~fzcmk efrrcr fbbs~ wm` e`~dc pf~cr% `~c d~c`zcrz mkhmdh z~`krpf~zc~r `kj `wc~`dc 7 zf 0? d&j`}
@nfsz 3?# fg efrrcr `~c `ensimk `kj zhc~c mr `kmkwc~rc ~ce`zmfkrhmp zf rc~si `ensimk
Gesmj `nrf~pzmfk js~mkd ` jtcee p~cwckzr efrrcrncmkd d~c`zc~
Efrrcr `~c kfz isbh `ggcbzcj n} _J p~crb~mpzmfk%nsz mkb~c`rc js~mkd pc~mzfkmzmr
8/3/2019 PD Solute Clearance
33/65
?
3??
0???
03??
>???
>3??
2???
Zfz`e~cifw`efgp~fzcmk%
id
? 7? 0>? 08? >:? 2?? 27?
Zmic% imk
E
E)@
H)@H
T`kd cz `e+ Kcph~fe Jm`e Z~`krpe`kz 021 0>:>):=% 0==8
Zfz`e ^cifw`e fg _~fzcmk mkJmggc~ckz Z~`krpf~z D~fspr
8/3/2019 PD Solute Clearance
34/65
_^CRB^M_ZMFK FG _J @BBF^JMKDZF KCT DSMJCEMKCR
Dcf~dm@n~`h`iIJ%G^B_
R~m^`i`bh`kj~`Icjmb`eBfeecdc'^crc`~bhMkrzmzszc
8/3/2019 PD Solute Clearance
35/65
Bemkmb`eBfkzcxz
3?&IBh~fkmbLmjkc}Jmrc`rcJm`nczcr
H}pc~zckrmfk
MHJ%Kfkriflc~
3?Ld%07?bi(NIM1>?+3NR@10+:=i>-
SF17??IE%~Lzw1?+2%pLzW10+3
Cbhf1Kf~i`ecacbzmfkg~`bzmfk
Mkmzm`zcjfkB@_J
>Ecxbh`kdcr%2zmicr&j`}
_CZ1Hmdh@wc~`dc
8/3/2019 PD Solute Clearance
36/65
Bemkmb`eI`k`dcickz
Hftjfcr@jcs`b}kccjrzfnc`rrcrrcj6
Th`z`jcs`b}z`~dczr`~cfpzmi`e6
Hfti`k}cxbh`kdcrjfcrhckccj6 Hftzf`bhmcwccswfecim`6
Mrmzmipf~z`kzzfp~crc~wc~crmjs`e~ck`e
gskbzmfk6Rz~`zcdmcr6
8/3/2019 PD Solute Clearance
37/65
Bemkmb`eCiph`rmr
,@nrckbcfgs~cimbr}ipzfir
,@wfmj`kbcfggesmjfwc~ef`j,Neffjp~crrs~cbfkz~fe
,_~crc~w`zmfkfg~crmjs`e~ck`egskbzmfk
,Tceekfs~mrhcj,_hfrphf~srbfkz~fe
,@bmj)n`rcn`e`kbc
,Bf~~cbzmfkfg`kcim` MR_J Dsmjcemkcr >??41 _JM >??4< >71 3>? )3>>
@jcs`zc_c~mzfkc`eJm`e}rmr
8/3/2019 PD Solute Clearance
38/65
Bemkmb`e
@rrcrrickz
Bec`~`kbc
@rrcrrickz
Ksz~mzmfk
@rrcrrickz
@jcs`b} @rrcrrickz`kj _~crb~mpzmfk `jasrzickz
Z`~dczicz _~crb~mpzmfk @jasrzickzBfkzmksc tmzhfsz @jasrzickz
^fszmkc gfeeft)sp tmzh`jcs`b} `rrcrrickz `z :ifkzh wmrmz
Defn`e `rrcrrickz fg z~c`zickzBhcbl _CZ ' Lz&WBfkrmjc~ `jasrzmkd p~crb~mpzmfk
Mkzc~wckzmfkr i`} nc ~csm~cj mg z`~dczr `~c kfz icz
]CR KF
@jcs`b}@rrcrrickz`kjMkzc~wckzmfkr
8/3/2019 PD Solute Clearance
39/65
Mkmzm`e Bfkrckrsr
8/3/2019 PD Solute Clearance
40/65
LZ&W B~Be
(imkmisi- (imkmisi-
B@_J(cwmjckbc- >+? 7?E&0+42i>BB_J(fpmkmfk- >+0 72E&0+42i>
KM_J(fpmkmfk- >+> 77E&0+42i>
TH@Z T@R ZHC ECWCE FG CWMJCKBC GF^ZHCRC ^CBFIICKJ@ZMFKR 6
KLG)JFPMDsmjcemkcr10==4Tccle}Zfz`eRfeszcBec`~`kbcDf`er
8/3/2019 PD Solute Clearance
41/65
Ne`lc(@jw_J0=8=- Mkb~c`rcj~mrltmzhLz&W50+3
Jc@ew`~f(@jw_J0==>-
Ecrr~mrltmzhLz&Wfg>+?zh`ktmzh50+4
Zcch`k(RciJm`0==>- Ecrr~mrltmzhic`kLz&W;0+8=
Dckcrzmc~(KJZ0==3-
Ecrr~mrltmzhhmdhc~mkmzm`eLz&Wf~B~Be
I`mf~b`(KJZ0==3- Ncrzrs~wmw`etmzhLz&W;0+=7
_`zmckzFszbfic1@jcs`b}p`~`iczc~r
8/3/2019 PD Solute Clearance
42/65
B@KSR@1Zhccwmjckbc K978?
_~frpcbzmwcBfhf~zfgB@_J%0==?)0==>
0:bckzc~rmkSR@'B`k`j`
^^9JI%@dc%BWJ%EftR+@en%RD@
Lz&W ?+0 9 mk 3# fg ^^ jc`zhB~ Be 3E&Tl&0+42 I> 9 4# ^^ jc`zh
Lz&W1 >+0% TBB 4?E&0+42 I> 9 > ]^ rs~wmw`e 48 #(pz-%43#(z-
A @i Rfb Kcph 0==71 4 (>- 0=8 ) >?4
8/3/2019 PD Solute Clearance
43/65
Bh`eeckdmkd CwmjckbcBfkzmkckz`ejmwmjc
8/3/2019 PD Solute Clearance
44/65
G~fi @rm`Gm~rzbfkz~`jmbzmfk
8/3/2019 PD Solute Clearance
45/65
@~c 2 cxbh`kdcr ` j`} `jcs`zc gf~
@rm`k p`zmckzr6
MrJm`e}rmrz`~dcz~c`emrzmb6 @~c@rm`krJmggc~ckz6
Mr@jcs`b}mipf~z`kzgf~@rm`kr6
Th`zmrzhci`dkmzsjcfgnckcgmz`kjfpzmi`ejfrcfgJm`e}rmr6
]CR KF
8/3/2019 PD Solute Clearance
46/65
8/3/2019 PD Solute Clearance
47/65
Em `kj Bhft%_JM% >??0
Bfrzfg_J
8/3/2019 PD Solute Clearance
48/65
Em `kj Bhft%_JM% >??0
Szmemq`zmfkfg_J
8/3/2019 PD Solute Clearance
49/65
HfkdLfkd1Mkmzm`ecwmjckbc
>}c`~`kj3}c`~rrs~wmw`e18>#%38+:#
@rs~wmw`e~`zcbfip`~`neczfbckzc~rtmzhrz`kj`~j:x>E&j`}%f~cwcknczzc~
B~frr)rcbzmfk`ebfhf~z1
Fke}00(3#-srcjif~czh`k7E&j`}
Ic`kLz&W0+47%BB~38E&tccl
EFTL_JM0==7
8/3/2019 PD Solute Clearance
50/65
Lf~c`(k90>8-
5>+0 ;>+0 pw`esc
>}c`~rs~wmw`e =4+= =3+7 k+r+
3}c`~rs~wmw`e 77+8# =4+=# ?+?32:
Zcbhkmscrs~w 34+># 44+4# k+r+
Rs~wmw`ercp`~`zcr`gzc~>}c`~r
BfxIfjce1@dc%JI%Lz&W Lz&W?+0mkb~c`rc`rrfbm`zcjtmzh~cjsbcj +^+2=#
Rs~wmw`ekfzjmggc~ckzrmdkmgmb`kze}tmzh1 Lz&W50+4(k90:-`kj0+4)>+?(k93?-
BB^;`kj57?E&tccl
KfhHA_JM>???
8/3/2019 PD Solute Clearance
51/65
Lf~c`
Cxbceeckz3}c`~rrs~wmw`emkhmdhLz&Wd~fsp1=8#
Lz&Wjczc~imkcje`~dce}n}nfj}rmqc17>wr3:ld~`zhc~zh`kp~crb~mpzmfk
If~cgci`ecrmkhmdhc~Lz&Wd~fsp1>7#wr4=#(_5?+?3- Eftc~pc~mzfkc`e`kjhmdhc~~ck`ebec`~`kbcmkhmdhLz&Wd~fsp1 _c~mzfkc`e0+4wr0+=(_5?+?3-
^ck`e?+?8wr?+>=(_5?+?3- Rs~wmw`enckcgmzkfz~ce`zcjzfpc~mzfkc`eLz&W
KfhHA_JM>???
8/3/2019 PD Solute Clearance
52/65
Zs~lc}(k922:
Ic`k`dc:>+>%JI0>+=# Lz&W >}c`~pzrs~wmw`e
)))))))))))))))))))))))))))))))))))))))))
0+3)0+7 8=# 0+4)0+8 =4#
0+=)>+0 0??#
;>+0 =2#
Bfiickzr1
@wc~`dcjLz&wmric`rs~cj+_`zmckzremwmkdefkdc~imdhzh`wceftc~`wc~`dcjLz&Wncb`srcfgif~c~c`jmkdrtmzheftc~lz&W
Sz`rB_JM>??0
8/3/2019 PD Solute Clearance
53/65
]`f P% HL A Kcph~fe >??0
Bhmk`
k90:7 @rrmdkcjmkzf2d~fspr Lz&W50+4%0+4)>+?`kj;>+? (`bbf~jmkdzfzhcm~n`rcemkcLz&W)kfk)~`kjfimqcj-
Rsnrcsckz_Jp~crb~mpzmfkr
@jasrzcjzflccpzhcLz&Wmkzhc`rrmdkcj~`kdc
Fwc~`ee>}c`~1`bzs`~m`ep`zmckzrs~wmw`e =?# zcbhkmscrs~wmw`e 47#
Rmdkmgmb`kzeftc~rs~wmw`emkLz&Wnceft0+4(p5?+?3- nszrmime`~gf~0+4)>+?';>+? 48#%=7#%=3#~crpcbzmwce}
]`f P% HL A Kcph~fe >??0
8/3/2019 PD Solute Clearance
54/65
Bhmk`
Fwc~`ee>}c`~`bzs`~m`ep`zmckzrs~wmw`e=?#%p`zmckz`kjzcbhkmscrs~wmw`e47#
Rmdkmgmb`kzeftc~rs~wmw`emkLz&Wnceft0+4(p5?+?3-%nszwc~}rmime`~gf~0+4)>+?`kj;>+?(48#%=7#%=3#~crpcbzmwce}-
Kfjmggc~ckbcmkpc~mzfkmzmr`kjhfrpmz`emq`zmfk~`zc
P`f]%HLAKcph~fe%>??0
8/3/2019 PD Solute Clearance
55/65
@rm`1 Ifskzmkd cwmjckbc
MrJm`e}rmrz`~dcz~c`emrzmb6
Cbfkfimbemimz`zmfkr
8/3/2019 PD Solute Clearance
56/65
Cwfewmkd bfkrckrsr
8/3/2019 PD Solute Clearance
57/65
Bemkmb`eCiph`rmr,@nrckbcfgs~cimbr}ipzfir
,@wfmj`kbcfggesmjfwc~ef`j
,Neffjp~crrs~cbfkz~fe
,_~crc~w`zmfkfg~crmjs`e~ck`egskbzmfk
,Tceekfs~mrhcj,_hfrphf~srbfkz~fe
,@bmj)n`rcn`e`kbc
,Bf~~cbzmfkfg`kcim` MR_J Dsmjcemkcr >??41 _JM >??4< >71 3>? )3>>
@jcs`zc_c~mzfkc`eJm`e}rmr
8/3/2019 PD Solute Clearance
58/65
Kfickbe`zs~crhmgz
Lz&W'B~Be~cbbfiickj`zmfkr
Dsmjcemkcrgf~z`~dczrgf~rfeszc`kjgesmj~cifw`emk`jsezp`zmckzrfkB_J
8/3/2019 PD Solute Clearance
59/65
RfeszcBec`~`kbcZ`~dcz
Fke}s~c`bec`~`kbcmr~cbfiickjcjgf~Bh~fkmb_c~mzfkc`eJm`e}rmr
Gfbsrrhmgzg~fiFpzmisizfImkmisi Cwmjckbcn`rcj
Cs`ef~if~czh`k Lz&W;0+4
8/3/2019 PD Solute Clearance
60/65
B~Bec`~`kbc
Kf~cbfiickj`zmfkrgf~B~Bez`~dczgf~B@_J
Gf~@_J B~Be:3E&tl&0+42i>
8/3/2019 PD Solute Clearance
61/65
^^G
Gf~~cecw`kzp`zmckzr
Ifkmzf~mkd Kfzecrrzh`k:7ifkzhr
8/3/2019 PD Solute Clearance
62/65
Bfkbesrmfk
@ lkftecjdc fg pc~mzfkc`e `k`zfi} `kj ph}rmfefd}mr mipf~z`kz mk zhc i`k`dcickz fg _J p`zmckzr
Mk p`~zmbse`~% mz hcepr zf rfewc p~fnecir tmzhbec`~`kbc `kj sez~`gmez~`zmfk
Mz `erf mip~fwcr skjc~rz`kjmkd fg zhc mip`bz fg kctzcbhkfefdmcr rsbh `r b}bec~r% e`~dc~ jtcee wfesicr%kct _J rfeszmfkr% czb+
8/3/2019 PD Solute Clearance
63/65
Bfkbesrmfk
Mkmzm`eDsmjcemkcr Fpmkmfkn`rcj1Kfk~`kjfimqcjbfhf~zrzsjmcr
Rfeszcbec`~`kbc{@jcs`b}
Fpzmi`ez`~dczbfkbcpz
Bh`eeckdmkdcwmjckbc @rm`1Imkmi`eLz&W Kfh1;>+0%nczzc~efkdzc~irs~wmw`e
Rqczf'T`kd1ksz~mzmfk`erz`zcnczzc~tmzhzfz`eLz&W;0+4
Rqczf1~cjsbcjif~z`emz}~mrlmknfzh`ks~mb`kjkfk`ks~mbp`zmckzr%nszkfbszfggecwcersddcrzcj
Ef1b~frrrcbzmfk`e1z~ckjzft`~jrnczzc~rs~wmw`etmzhhmdhc~zfz`elz&W%kfbszfggecwcersddcrzcj
Ef1~`kjfimqcjrzsj}rsddcrzLz&W50+4mr`rrfbm`zcjtmzhif~cp~fnecir
]`f1kfk)~`kjfimqcjrzsj}1mkb~c`rcjif~z`emz}gf~rsrz`mkcjLz&W50+4
8/3/2019 PD Solute Clearance
64/65
@rm`k`jcs`b}z`~dczr
Bfkrckrsrrhmgz Rfeszcbec`~`kbc efkc{@jcs`b}1Bemkmb`e`rrcrrickz`pp~f`bh
Imkmi`ez`~dczbfkbcpz
^crmjs`e~ck`egskbzmfkciph`rmr
8/3/2019 PD Solute Clearance
65/65
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