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Effects ofEffects of
DiureticsDiureticsExerciseExerciseNo. 9No. 9
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Objective:Objective: To define
diuretics and
note its effects inthe body.
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Observation:Observation:Vol ofVol ofUrineUrine
OutpuOutputt
ColdColdWateWate
rr
CokCok
ee
FurosemiFurosemi
dede
AfterAfter30 min30 min
220 ml 40 ml 153 ml
After 1After 1
hrhr
457 ml 80 ml 453 ml
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Vol ofVol of
UrineUrineOutpuOutpu
tt
ColdColdWateWate
rr
CokCokee
FurosemiFurosemidede
AfterAfter
1.5 hrs1.5 hrs
640 ml 100
ml
713 ml
After 2After 2hrshrs
777 ml 110ml
923 ml
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Conclusion:Conclusion:We therefore conclude
that diuretics are amongstcommonly used drugs. They
act by diminishing sodiumreabsorption at different
sites in the nephron, therebyincreasing urinary sodium
and water losses. The ability
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made diuretics useful in thetreatment of a variety of
conditions particularlyedematous states and
hypertension.
Diuretics help rid your
body of salt and water. Theywork by making your
kidneys put more sodium
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and goes with the blood. That decreases the amount
of fluid flowing through yourblood vessels, which
reduces pressure on walls ofyour arteries.
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Questions:Questions:
1. What is1. What is
diuretics?diuretics?
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Diuretics are called water
pills which help body releasefluids. It helps in loweringblood pressure by causingkidneys to produce moresodium and in turn helps in
removal of fluids throughurination. They are used as
1st line treatment high BP.
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2. What is the2. What is the
mechanism ofmechanism of
action ofaction ofdiuretics?diuretics?
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The diuretics argenerally divided intothree major classes whichare distinguished by thesite at which they impairsodium reabsorption:
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Loop diureticsLoop diuretics inhibit the
sodium-potassium-chloridecotransporter
in the thickascending limb
of loop ofhenle.
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di idi ti lik l d
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diureticsdiuretics unlike loop andthiazide diuretics, some of
these drugs do not actdirectly on sodium transport.
Some drugs in this classantagonize the actions of
aldosterone (aldosteronereceptor antagonists) at
the distal segment of the
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Other
potassium-sparing diureticsdirectly inhibit sodiumchannels associated withthe aldosterone-sensitivesodium pump, andtherefore have similareffects on potassium and
h dro en ion as the
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3. What is the3. What is the
importance ofimportance of
diuretics?diuretics?
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Diuretics are the commonmedication used in the
treatment of high bloodpressure. They are relatively
inexpensive and are widelyavailable. In in addition to highblood pressure, diuretics areoften used to treat otherillnesses like edema and heart
failure Many diuretics can
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