Campus des Cordeliers
Address: 15 rue de l’École de Médecine
75006 Paris – France
Metro: Line 4 or 10, Odéon Station
RER (city trains): Line B, Saint-Michel or
Luxembourg station
Line C, Saint-Michel station
Bus: 38, 27, 58 (Stops: Rue des Écoles or
Odéon)
Meeting location
Novotel Paris les Halles
Address: 8 Place Marguerite de Navarre
75001 Paris – France
Metro: Lines 4, 7 and 11, get off at the Châtelet
station and take the Place Saint Opportune exit. On
metro lines 1 and 14, take the Rue de Rivoli exit. On
RER lines A, B and D, take the Forum des Halles
exit then Rue Berger.
RER (city trains): Lines A, B and D, get off at
Châtelet-Les Halles station and take the Forum des
Halles exit then Rue Berger.
Bus: 38 (stop: Châtelet) and 27 (stop: Pont neuf-
Louvre)
Accommodation
Monday 18 June:
11:30 AM : Lunch Buffet
12:50 PM : Welcome Olivier Chazouillères, Paris
1:00 PM: Disease staging – Olivier Chazouillères & Annarosa Floreani,
Padova
Serum tests Cyriel Ponsioen, Amsterdam
Histology Stefan Hubscher, Birmingham
Elastography Christophe Corpechot, Paris
2:30 PM Gut-liver axis Chantal Housset, Paris & Johannes Espolin Roksund
Hov, Oslo
The microbiome and the gut-liver axis, Harry Sokol, Paris
Impact of liver and colon diseases on each other, Annika Bergquist,
Stockholm
Immunology of the gut-liver axis, Evaggelia Liaskou, Birmingham
4:00 PM: Coffee Break
4:30 PM: Working groups
Organoids models and biobanking,
Mario Strazzabosco, Yale & Michael Trauner, Vienna
Natural history and Database,
Cyriel Ponsioen, Amsterdam & Christopher Bowlus, UC Davis
Imaging studies, Christoph Schramm, Hamburg & Lionel Arrivé, Paris
Malignancies in PSC Luca Fabris, Padova & Jesus Banales, San
Sebastian
6:00 PM: Patients’Associations (Albi, PSC Europe, PSC Partners) and Fonds
CSP
8:00 PM: Dinner
Tuesday 19 June:
8 :30 AM: Treatment Gideon Hirschfield, Birmingham & David Assis, Yale
Clinical trials, Cynthia Levy, Miami
Bile acid targeting, Emina Halibasic, Vienna
Immune targeting Johannes Herkel, Hamburg
Fibrosis targeting, Yuri Popov, Boston
10:30 AM: Coffee break
11:00 AM Working group leaders reports & unmet needs Ulrich
Beuers, Amsterdam & Tom Karlsen, Oslo
Organoids models and biobanking
Natural history and Database
Imaging studies
Malignancies in PSC
ERN Ansgar Lohse, Hamburg & Albert Pares, Barcelona
Working groups format Ulrich Beuers, Amsterdam & Tom Karlsen, Oslo
12:30 AM Concluding remarks Chantal Housset & Olivier Chazouillères,
Paris
12:45 AM – 2:30 PM : Lunch Buffet
Chairs: Cyriel Ponsioen, Amsterdam & Christopher Bowlus, UC Davis
During the 1.5 hours working group session on Natural History & Database we welcome proposals on mining the existing IPSCSG retrospective database for observational studies.
Alternatively, joint ventures between several centers are also welcomed. Participants are asked to present their proposals in a 3-4 slides presentation.
Also, we invite attendees to participate in discussions on a uniform prospective IPSCSG database, tentatively coined the IPSCR.
Chairs: Jesus M. Banales & Luca Fabris
Selected Proposals
Whole exome sequencing of PSC-associated biliary tract cancers (Trine Folseraas, Oslo)
CCA Registry database (update: Jesus M. Banales, San Sebastian)
Animal models of PSC-CCA (update: Luca Fabris, Padua)
International validation study of new non-invasive protein biomarkers inserum extracellular vesicles of PSC, CCA, HCC patients (Jesus M. Banales, San Sebastian)
Imaging of peribiliary glands and histo-morphology correlates in PSC-CCA. A multicentre international study proposal (V. Cardinale, G. Carpino, Rome)
Metabolomics and lipidomics in assessment of disease progression and risk for biliary dysplasia in PSC (M. Farkkila, Helsinki)
PSC to CCA - Which role does the stroma play? (J. Mertens, Zurich)
Role of PSC-related intestinal dysbiosis in colitis-associated colorectal cancer (Massimo C. Fantini, Rome)
Expected Outcomes
This workshop will propose international collaborative studies for participants interested in the search of non-invasive biomarkers for early diagnosis of CCA in PSC patients, and on the prediction of CCA development, using innovative methods, including molecular, histological and radiological approaches. Moreover, novel collaborative projects on the association between genetics and PSC-associated biliary cancer will be presented. Finally, collaborative proposals on new animal models for the study of PSC-CCA, novel strategies for the analysis of the role of stroma in the progression of PSC to CCA, and on the microbiome in PSC-related colorectal cancer will be outlined.
Olivier Chazouillères, Christophe Corpechot and Chantal Housset
Sorbonne Université & Inserm, Saint-Antoine Research Center (CRSA)
Assistance Publique-Hôpitaux de Paris (AP-HP), Saint-Antoine Hospital, Hepatology
Department, Reference Center for Inflammatory Biliary diseases and Auto-immune Hepatitis
Nelly Guitard and Virginie Tsilibaris
FILFOIE (French Network for rare liver disease).
Contact: Nelly Guitard ([email protected])
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