Rina Das, PhDDivision of Extramural Scientific Programs
National Institute on Minority health and Health Disparities (NIMHD)
NIMHD Mission, Programs and Funding Opportunities
OUTLINE
NIMHD Mission Minority Health and Health Disparities NIMHD Research Framework NIMHD Programs Social Determinants of Health and Health Disparities COVID-19 Disparities and NIMHD Opportunities Funding Opportunity Announcements NIMHD Resources
NIMHD Mission The mission of NIMHD is to lead scientific research to improve minority health and eliminate health disparities.
To accomplish this, NIMHD: • Plans, reviews, coordinates, and evaluates all minority health
and health disparities research and activities of the National Institutes of Health
• Conducts and supports research in minority health and health disparities
• Promotes and supports the training of a diverse research workforce
• Translates and disseminates research information • Fosters innovative collaborations and partnerships
Minority Health Definition
• Minority Health-Distinctive health characteristics and attributes of the minority racial and/or ethnic groups in the U.S.
Minority Health Populations- OMB categories• Black or African American• Asian • American Indian or Alaska Native• Native Hawaiian or Other Pacific Islander• Latino or Hispanic
Health Disparities Definition
• Health Disparity-A health disparity is defined as a health difference that adversely affects disadvantaged populations, based on one or more of the health outcomes.
• Health disparity populations include racial/ethnic minorities, low SES, sexual and gender minorities, and underserved rural populations.
https://nimhd.nih.gov/about/overview/research-framework/nimhd-framework.html
NIMHD SCIENCE VISIONNew Perspectives to Advance Minority Health and Health Disparities Research
AJPH 2019, Vol 109, No. S1
• Editor’s choice by NIMHD Director Dr. Eliseo J. Pérez-Stable and NIH Director Dr. Francis S. Collins
• Definitions for minority health, health disparities, and NIMHD Research Framework
• Thirty research strategies in methods and measurement, etiology, and interventions
• Multi-year process with more than 100 authors, including NIH intramural and extramural scientific staff, along with external scientists
https://www.nimhd.nih.gov/about/overview/science-visioning/
Strategies to Promote the Advancement of Health Disparities Science
► Indicators for Measuring Health Disparities
► Methods for Analyzing Health Determinants Contributing to Health Disparities
► Evaluating Health Disparities Research► Health Disparities in The Era of
Big Data
Methods and Measurement► Social Determinants► Environmental Exposures, Biological
Pathways and Mechanisms► Life Course Approaches► Health Services
Etiology► Guiding Principles► Approaches► Methods and Evaluation► Dissemination and Implementation
(Scalability)
Interventions
https://www.nimhd.nih.gov/about/overview/science-visioning/visioning-strategies.html
Extramural Programs at NIMHDNIMHD funds programs in diseases relevant to racial/ethnic minorities and other health disparity populations Focus on basic, translational and applied biomedical research Infrastructure and Training grants to build capacity for biomedical researchPrograms include:
Investigator Initiated Research Project Grants (R01, R21, R03 ) Centers of Excellence (COE) Program, (U54) Research Centers in Minority Institutions (RCMI) Program (U54) Community-Based Participatory Research (CBPR) Initiative (U01) Transdisciplinary Collaborative Centers (TCC) Initiative (U54) Small Business Innovation Research/Small Business Technology Transfer
(SBIR/STTR) Program (R43, R44/ R41, R42) Science Education Program (R25) Loan repayment program (L32, L60) Conference Grants (R13) Academic Research Enhancement Awards (AREA, R15) Training Grants (T37, K01, K08, K23, K99, K18)
Research Training Programs at NIMHD Diversity Supplements T37 MHRT Minority Health and Health Disparities Research Training NRSA Pre-doctoral fellowships
• F30 -Individual Predoctoral MD/PhD or Other Dual-Doctoral Degree Fellowship (Parent F30)
• F31 -Individual Predoctoral Fellowship (Parent F31) • F31D -Individual Predoctoral Fellowship to Promote Diversity
in Health-Related Research (Parent F31 - Diversity) NRSA Post-doctoral fellowships: F32- Individual Postdoctoral
fellowships Career Development Program: K01, K08, K23, K99 mechanisms Loan Repayment Program
• L32 -Loan Repayment Program for Clinical Research for Persons from Disadvantaged Backgrounds
• L60 -Loan Repayment Program for Minority Health and Health Disparities Research
NIMHD Extramural Scientific Program Areas
Clinical and Health Services
Research
Integrative Biological and
Behavioral Sciences
Community Health and Population Sciences
Clinical and Health Services Research (CHSR)
This research area focuses on clinical research to generate new knowledge to improve health outcomes and quality of healthcare for minority and other disparity populations. The scientific portfolio includes extramural grants, cooperative agreements and training awards related to the following:
Development of preventive, diagnostic and therapeutic healthcare interventions that can contribute to reducing health disparities;
Research in clinical settings that addresses access to health care, improvement of patient safety, reduction of medical errors and healthcare delivery costs, coordination of care, impact of health information technology on coordination and quality of care, shared decision making on patient satisfaction and health outcomes, patient-clinician communication and quality of health care; and
How healthcare financing and organizational structure of healthcare systems affect access, quality and costs of care in minority and other disparity populations
Focus on understanding biological and behavioral mechanisms and pathways by which sociocultural and environmental factors become embodied within individuals to influence resilience and susceptibility to adverse health conditions at the individual, interpersonal and family levels.
Integrative Biological and Behavioral Sciences (IBBS)
Research on interpersonal, family, neighborhood, community and societal-level mechanisms and pathways that influence disease risk, resilience, morbidity, and mortality in health disparity populations.• Epidemiology• Pathways and Determinants of Population Health• Pathways and Determinants of Community Health• Community-Based Prevention and Health Promotion
Interventions
Community Health and Population Sciences (CHPS)
Social Determinants & Health Disparities
SES Place Education Discrimination
Relative risk of All-Cause Mortality by U.S. Annual Household Income Level
Life Expectancy at Birth for U.S. Census Tracts, 2010-2015 (CDC)
Place Matters
• Life expectancy in Washington D.C. area can vary by neighborhood
• The average life expectancy in the District of Columbia and Prince George's County is 78 years - 8 years shorter than for babies born in either Arlington or Fairfax Counties with 86 years.
• https://societyhealth.vcu.edu/work/the-projects/mapping-life-expectancy.html
Prevalence Obesity among Youths by Head of Household, ≤ HS vs. College Degree, US, 2011-14
% Males % Females
Whites 16.9 / 9.6 22.5 / 7.5
Blacks 21.1 / 14.5 21.0 / 16.3
Latinos 24.4 / 12.9 23.9 / 14.0
Asian 16.9 / 7.9 9.2/ 3.3
MMWR February 16, 2018; 67: 186-189
Societal Discrimination and Health Outcomes
Structural racism associated with obesity and obesogenic environment in Blacks. Racial residential segregation/neighborhood disadvantage and
inequality in poverty, unemployment, and homeownership were associated with higher obesity rates in blacks; Associations varied by county racial composition. (Bell et al, 2019; Int J Environ Res Public Health. 2019 Mar; 16(5): 861).
Societal discrimination and adverse behavioral health outcomes in adolescents. Societal discrimination is common (45%) and was associated with
increased substance use and greater odds of depression and ADHD (Leventhal AM et al, JAMA Pediatrics online August 20, 2018)
COVID-19 & Disparities
JAMA Viewpoint: COVID-19 and Racial/Ethnic Disparities Webb Hooper M, Nápoles AM, Pérez-Stable EJ
• Published online JAMA, May 11, 2020 • The article addresses the disproportionate burden of COVID-19
on racial and ethnic minority populations • Possible underlying causes of this burden related to long-
standing disparities and disadvantage, higher rates of co-morbid conditions and crowding in housing and communities
• Imperative need for implementing prevention and healthcare strategies aligned with the needs of these communities to address effects of pandemic and mitigation efforts as well as underlying inequities
• https://jamanetwork.com/journals/jama/fullarticle/2766098
COVID-19 Hospitalization Data from CDC
New York City Data on COVID-19 Disparities
Age-adjusted rates of lab confirmed COVID-19 non hospitalized cases, estimated non-fatal hospitalized cases, and patients known to have died 100,000 by race/ethnicity group as of April 16,2020
Non-hospitalized Non-fatal hospitalized Known to have died Black/African
American 335.5 271.7 92.3
Hispanic/Latino 271.6 198.6 74.3
White 190.4 114.5 45.2
Asian 95.1 82.2 34.5
0 100 200 300 400 0 100 200 300 400 0 100 200 300 400
Age-adjusted case rate per 100,000
Non-hospitalized Non-fatal hospitalized Known to have died
Source-CDC reports
Data on COVID-19 Disparities in Louisiana and Georgia
• Study included data from large cohort in Louisiana with 3481 Covid-19–positive patients in Ochsner Health System.
• Blacks represent only 31% of the patients routinely cared for, but they made up 76.9% of Covid-19–positive patients hospitalized within the health system.
• Blacks represent approximately 80% of the patients who received critical care or mechanical ventilation.
• Blacks were overrepresented (70.6%)among all patients who died in the hospital.
• Comorbidities, obesity, diabetes, access to care, occupation, etc.
For details see: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269015/N Engl J Med. 2020 May 27
Number of hospitalized patients with COVID-19 (N = 305) from 8 hospitals in Georgia; Blacks were overrepresented (over 80%).For details see:Gold JA, et al. March 2020. MMWR Morb Mortal Wkly Rep 2020;69:545-550 http://dx.doi.org/10.15585/mmwr.mm6918e1
Georgia DataLouisiana Data
Impact of COVID-19 Outbreak on Minority Health and Health DisparitiesNOT-MD-20-019 is soliciting research with health disparitypopulations that seeks to understand:
Learn more at https://grants.nih.gov/grants/guide/notice-files/NOT-MD-20-019.html
• How state and local policies and initiatives mitigate or exacerbate disparities in health services use and health outcomes
• The role that community-level protective and resilience factors and interventions have in mitigating the effects of the sector disruptions that the COVID-19 outbreak causes
• How behavioral and/or biological mechanisms may contribute to COVID-19 manifestations
• Receipt date: May 2020- May 2021
RADx-UP InitiativesNOT-OD-20-112
• Notice that NIH plans to publish four Funding Opportunity Announcements (FOAs) as part of the Rapid Acceleration of Diagnostics for Underserved Populations (RADx-UP) initiative to solicit research on COVID-19 diagnostic testing in underserved and vulnerable populations.
• To conduct community-engaged research to understand COVID-19 disparities and to increase access and effectiveness of diagnostic testing interventions among underserved COVID-19 medically and/or socially vulnerable populations.
• Supplement to existing grants for large consortia, multi-site trials, centers and other current networks that have adequate capacity, infrastructure, and established community-engaged relationships to support large-scale testing interventions or have the capacity to ramp up quickly to reach underserved or vulnerable populations
• First Estimated Application Due Date: July 2020Earliest Estimated Award Date: September 2020
• https://grants.nih.gov/grants/guide/notice-files/NOT-OD-20-112.html
Supplements to Promote Community Interventions for COVID-19
NOT-MD-20-022 is soliciting research for Community Interventions to Reduce the Impact of COVID-19 on Health Disparity and Other Vulnerable Populations.
Learn more at https://grants.nih.gov/grants/guide/notice-files/NOT-MD-20-022.html
• Research to test community interventions focused on the prevention (or slowing) of COVID-19 transmission, evaluate local and state policies and programs intended to mitigate COVID-19 exposure and improve adherence, and reduce the negative impact of the multifaceted consequences on the health of US health disparity and other vulnerable populations.
• Receipt date: June 10-Dec 29, 2020• Budget: 250K direct cost for one year
NIH COVID-19Information for Applicants and Recipients
• This is a rapidly evolving situation • Visit the NIH grants page often for the
latest updates
29
Stay Up to Date https://grants.nih.gov/policy/natural-disasters/corona-virus.htm
Funding Opportunities at NIMHD
https://nimhd.nih.gov/funding/nimhd-funding/active_foa.html
Research FOAs
Number ActivityCode(s) Title Expiration
DatePA-18-484PA-18-345
R01 Research Project Grant (Parent R01) 01-08-2021
PAR-20-150 R21*NIMHD Exploratory/Developmental Research Grant Program (R21)
05-08-2023
PAR-19-135PAR-19-134
R15 Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools
01-08-2021
PA-18-648 R13, U13 NIH Support for Conferences and Scientific Meetings (Parent R13/U13) 01-08-2021
Fellowships
Number ActivityCode(s) Title Expiration
Date
PA-18-671 F31 Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship
01-08-2021
PA-18-666 F31 NRSA Individual Predoctoral Fellowship to Promote Diversity in Health-Related Research
01-08-2021
PA-18-673PA-16-306 F30
NRSA Fellowship for Students at Institutions With/Without NIH-Funded Institutional Predoctoral Dual-Degree Training Programs
01-08-2021
PA-18-670 F32NRSA Individual Postdoctoral Fellowship
01-08-2021
Training Number Activity
Code(s) Title ExpirationDate
PAR-18-881PAR-18-882
K18
Short-term Mentored Career Enhancement Awards for Mid-Career Investigators to Integrate Basic Behavioral and Social Sciences
07-13-2020
PA-18-397PA-18-398
K99/R00NIH Pathway to Independence Award
01-08-2021
PA-18-369PA-18-363
K01Mentored Research Scientist Development Award
01-08-2021
PA-18-373K08
Mentored Clinical Scientist Research Career Development Award
01-08-2021
PA-18-374PA-18-375
K23Mentored Patient-Oriented Research Career Development Award
01-08-2021
NIMHD Extramural Scientific Program Areas
Clinical and Health Services
Research
Integrative Biological and
Behavioral Sciences
Community Health and Population Sciences
CHSR FOAs
Number ActivityCode(s) Title Expiration
Date
PAR-18-747PAR-18-745
R01R21
Addressing the Challenges of the Opioid Epidemic in Minority Health and Health Disparities Research in the U.S. (Clinical Trial Optional)
11-14-2020
PAR-18-286PAR-18-287
R01R21
Health Services Research on Minority Health and Health Disparities
Renewal soon
PAR-20-079R01 Surgical Disparities Research 07-06-2022
PAR-19-093 R01
Leveraging Health Information Technology (Health IT) to Address Minority Health and Health Disparities (R01 Clinical Trial Optional)
12-05-2021
CHSR FOAs
Number ActivityCode(s) Title Expiration
Date
PAR-18-189PAR-18-190
R01R21
Multidisciplinary Studies of HIV/AIDS and Aging
09-08-2020
PAR-19-162PAR-19-163
R01R21
Accelerating the Pace of Child Health Research Using Existing Data from the Adolescent Brain Cognitive Development (ABCD) Study (Clinical Trial Not Allowed)
09-08-2021
PA-20-172 R01 Long-Term Effects of Disasters on Health Care Systems Serving Health Disparity Populations (R01- Clinical Trial Optional)
09-08-2023
Minority Health and Health Disparities in Maternal Mortality and Morbidity
NOT-OD-20-104 aims to support administrative supplements to support research on how to mitigate preventable Maternal Mortality, decrease severe maternal morbidity, and promote health equity in the U.S.Due: June 22,2020
RFA-MD-20-008 aims to support research that tests clinical, social behavioral and health care system system interventions to address racial disparities in maternal mortality and morbidity (MMM) in the U.S.
Learn more at https://grants.nih.gov/grants/guide/notice-files/NOT-OD-20-104.html
http://nimhd.nih.gov/funding
IBBS FOAs
Number ActivityCode(s) Title Expiration
Date
PA-17-041R01
Addressing the Etiology of Health Disparities and Health Advantages Among Immigrant Populations
Renewal soon
PA-18-284R01
Addressing Health Disparities through Effective Interventions Among Immigrant Populations
Renewal soon
PAR-20-088PAR-20-081
R01R21
Mechanisms of Disparities in Chronic Liver Diseases and Cancer
04-02-2022
PAR-20-164 R01Mechanisms and Consequences of Sleep Disparities in the U.S.
07-15-2022
Mechanisms and Consequences of Sleep Disparities in the U.S.
Research should focus on U.S. Health Disparity Populations:(1) Underlying pathways and mechanisms that explain sleep
deficiencies and/or(2) Whether sleep deficiencies explain disparities for health
outcomesConsidering causes from socioecological framework and demonstrating integration of expertise on sleep and health disparities is considered highly responsive.
Contact: Drs. Rina Das and Nancy Jones, NIMHD
PAR-20-164 (R01) NIMHD, NCI, NHLBI*,NIA, NIAAA, NINDS
IBBS FOAs
Number ActivityCode(s) Title Expiration
Date
PAR-19-372R01
Social Epigenomics Research Focused on Minority Health and Health Disparities
11-07-2021
PAR-19-018PAR-19-019
R01R21
Mechanisms of Disparities in Etiology and Outcomes of Lung Cancer in the U.S.: The Role of Risk and Protective Factors (R01 Clinical Trial Not Allowed)
03-05-2021
PAR-19-373 R01
Research on biopsychosocial factors of social connectedness and isolation on health, wellbeing, illness, and recovery (R01 Clinical trial not allowed)
03-18-2021
Social Epigenomics Research Focused on Minority Health and Health Disparities.
Research should focus on U.S. Health Disparity Populations:(1) Understand mechanisms by which social factors lead to epigenetic
changes that affect minority health and/or health disparities, and (2) Promote epigenetics research to better predict disease risk or
resiliency among health disparity populations.
Social determinants of health are the conditions in which people are born, grow, live, work and age. Help understand how social determinants (both positive and negative) may affect human biology and ultimately health outcomes.
Contact: Dr. Rina Das, NIMHD
PAR-19-372 (R01) NIMHD, NIA, NHGRI
CHPS FOAs
Number ActivityCode(s) Title Expiration
Date
PAR-20-180 R01
Identifying Innovative Mechanisms or Interventions that Target Multimorbidity and Its Consequences (R01 Clinical Trial Optional)
09-08-2023
PA-18-729PA-18-728
R01 R21
Research on the Health of Transgender and Gender Nonconforming Populations (R01 Clinical Trial Optional)
01-08-2021
PA-18-651 R01Developmentally Tailored HIV Prevention and Care Research for Adolescents and Young Adults
01-08-2021
CHPS FOAs
Number ActivityCode(s) Title Expiration
Date
PAR-17-484R01
Collaborative Minority Health and Health Disparities Research with Tribal Epidemiology Centers
Renewal soon
PAR-20-048 U24
Building Population Health Research Capacity in the U.S. Affiliated Pacific Islands (U24 – Clinical Trial Not Allowed)
07-16-2022
PAR-18-324 R01Testing Interventions for Health-Enhancing Physical Activity
01-08-2021
PA-17-444PA-17-446
R01R21
Ethical, Legal, and Social Implications (ELSI) of Genomics Research Project Grant Program
09-08-2020
Rural Health Disparities Research Resource HubsNOT-MD-20-010 aims to understand challenges to conducting rural health disparities research, particularly for early stage investigators
• Supplements to current Centers of Excellence and RCMI awardees to develop multi-sectoral coalitions to enhance capacity to conduct rural health disparities research.
• Initiative is one of NIH’s contributions to the HHS Rural Health Strategic Plan.
• If successful, this program can serve as a pilot for a larger initiative involving other NIH ICs and Federal partners.
For details: https://grants.nih.gov/grants/guide/notice-files/NOT-MD-20-010.html
NIMHD Health Disparities Research Institute
The National Institute on Minority Health and Health Disparities (NIMHD) hosts the Health Disparities Research Institute (HDRI) every year for one week (~August 2020). The HDRI aims to support the research career development of promising minority health/health disparities research scientists early in their careers and stimulate research in the disciplines supported by health disparities science.The program will feature lectures, mock grant review, seminars, small group discussions on research relevant to minority health and health disparities. It will also include sessions with NIH scientific staff engaged in related health disparities research across the various institutes and centers.Check our website NIMHD Health Disparities Research Institute website.
Resources
Common Data Elements for Social Determinants of Health
Adoption of CDEs and standard measures will promote and facilitate:• Data harmonization.• Domestic and international
cross-study analysis.• Accelerated translational
research.• Greater understanding of the
causes of health disparities.• Effective interventions to
reduce disparities.• COVID-19 measures
Toolbox of Measures on SDOH
Addressing Health Disparities Through the Utilization of Health Information Technology
Supplement to Medical CareJune 2019, Vol 57, Supplement2
This special supplement, sponsored by NIMHD, with an introductory editorial led by NIMHD Director Eliseo J. Pérez-Stable, M.D., with NIMHD Health Scientist Administrator Beda Jean-Francois, Ph.D., and NIMHD Chief of Staff Courtney Ferrell Aklin, Ph.D., reports on the use of health information technologies to reduce disparities in health care access and outcomes by increasing access to care, improving quality of healthcare and by promoting better patient-clinician communication
Workshop Report on the Causes and Consequences of Sleep Health Disparities Report on 2018 NIMHD, NHLBI, OBSSR Workshop where experts from sleep and health disparities developed strategies to address SHDs:• Develop and promote integrative
research to investigate causes and consequences
• Develop interventions• Build research infrastructure and
training opportunities• PAR-20-164 on SHD renewed:
http://nimhd.nih.gov/funding
Sleep Health Disparity (SHD): A difference in one or more dimensions of sleep health (regularity, quality, alertness, timing, efficiency, and duration)—on a consistent basis—that adversely affects designated disadvantaged populations.
Precision Medicine & Health Disparities ResearchEthnicity & Disease Supplement Vol. 30, April 2020
• Presents initial findings from NIMHD’s Transdisciplinary Collaborative Centers on Precision Medicine
• First set of NIH-funded papers focused on precision medicine research addressing minority health and health disparities
Foreword by Drs. Nishadi Rajapakse, Michael H. Sayre, Eliseo J. Pérez-Stable
NIMHD RESOURCEShttps://hdpulse.nimhd.nih.gov/
NIMHD Resources
For Research ApplicantsThe resources highlighted on this page may be helpful to research applicants interested in current fundingopportunities as well as NIH policies that guide NIH-funded grant program operations.Grant Policies and Guidance
• NIH Office of Extramural Research• Grants Process Overview• New and Early Stage Investigator Policies• Clinical Trial Requirements for Grants & Contracts• Video: NIH Grant Basics• Video: How to Apply – Four Interactive Tutorials• Video: NIH Peer Review Briefing for Basic Research Applicants and Reviewers• Video: 8 Ways to Successfully Navigate NIH Peer Review and Get an R01 Grant• Video: 8 Ways to Successfully Navigate NIH Peer Review and Get a Fellowship Grant• Video: What Happens to Your NIH Grant Application• Video: Insights from Peer Review• Video: Top 10 Peer Review Q&As for NIH Applicants
Learn More: https://nimhd.nih.gov/resources/
https://nimhd.nih.gov/programs/extramural/research-areas/index.html
Advice for New InvestigatorsSubscribe to the NIH Guide (http://grants.nih.gov/grants/guide/)
Clinical Trial Requirements https://grants.nih.gov/policy/clinical-trials.htm
Look at funded projects on NIH RePORTER(http://projectreporter.nih.gov/reporter.cfm)
Watch CSR Videos for Applicants (https://public.csr.nih.gov/Pages/csrwebinar.aspx)
Sample applications https://www.niaid.nih.gov/grants-contracts/sample-applications
Rina Das: [email protected]
Top Related