What has changed ?
The patient
Improvement in medical care « Surgery is a step in the medical history»
Preoperative explorations
Technology And Devices
Improvement in postoperative management (Fast-track programs)
Future direction
• Teaching and training surgery • Development of new devices to
decrease invasiveness – transanal endoscopic microsurgery – Robotic-assisted surgery
• Improve the tools involved into diagnosis and gut exploration – Confocal Endomicroscopy
Mantoo et al. Colorectal Dis 2013 Wong et al. Dis colon Rectum 2011
Pre-clinical model as a new tool to overcome challenges
• LGA: porcine plateform
SNS in experimental colitis Methods:
1. Endoscopic and confocal endomicroscopy and
histology
1. Functional approach of the barrier: Permeability and motricity
Bregeon J, Cordeiro A personal data
SNS in experimental colitis 0.09
T0 SHAM – T24H SNS – T24H
Endoscopy
T0
SH
AM
T
24H
S
NS
T2
4H
* *
Endomicroscopy
Bregeon J, Cordeiro A personal data
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