Michael Bowdery

Interim Head of NISCHR

Capacity Building and Opportunities for Capacity Building in CTUs in Wales

UKCRC CTU Directors Meeting: 13 November 2012

Content

Purpose:To introduce you to some of the ways in which NISCHR supports capacity building in Welsh Clinical Trials Units

Content:Strategic contextNISCHR Trials UnitsCapacity building in Welsh Trials Units

NISCHR Strategy

Supporting excellence and innovation

Investing in the future (capacity building)

Streamlining the research process and improving the research environment

Increasing collaboration within and across sectors: HEI, NHS and commercial

NISCHR Trials Units

5 UKCRC Registered Trials Units in Wales 3 are NISCHR funded for Trials Unit activity

£8.6m investment over 5 years Combined portfolio worth c£105m (as at March 2012) Funded to work on an all-Wales basis and beyond Units have complementary specialisms All have a remit for core activity involving:

development of new trials delivering funded trials methodological development unit management and strategic development

Two NHS Research Design and Conduct Services Collaborating with 17 RRGs and Health Economists

NISCHR Trials Units

South East Wales Trials Unit (SEWTU) Led by Professor Kerry Hood, Cardiff SEWTU themes: Infections, Behaviour Change,

Children & Young People, Medical Devices Noted strength in working across Primary Care

North Wales Organisation for Randomised Trials in Health (NWORTH)

Led by Professor Bob Woods, Bangor Focus on: pragmatic trials, complex interventions, social

care and SOP development Developing expertise in Ageing and Dementia, Mental

Health, Muscular-Skeletal trials

NISCHR Trials Units

West Wales Organisation for Rigorous Trials in Health and Social Care (WWORTH)

Led by Professor Ian Russell, Swansea Focus on: Secondary Care trials Noted interest in Emergency Care, Gastroenterology,

Diabetes, Mental Health, Rheumatology & trials involving and exploring the use of routine data

Other Trials Units

Wales Cancer Trials Unit (WCTU) Led by Gareth Griffiths, Cardiff Core-funding from CRUK and Marie Curie Cancer focus (cancer therapies, primary care and

palliative care) but non-cancer elements emerging

Haematology Trials Unit Led by Dr Robert Hills, Cardiff Funding from CRUK, MRC, Leukaemia & Lymphoma

Research Fund (and others) Lead centre for acute myeloid leukaemia trials in the UK

NISCHR Clinical Research Infrastructure

NISCHR ClinicalResearch Centre

NISCHR RegisteredResearch Groups

NISCHR Infrastructure

Support Groups

NISCHR Trials

Units

Staff retention and developmentBridging funding between projects

Staff stability

Funding shortfalls within projects

Academic development areas outside the focused funded projects – critical for academic development and preparing for future projects

Methodological development and training (workstream supported by core-funding)

Impact of core funding on capacity building (1)

North Wales Organisation for Randomised Trials in Health (NWORTH)

Before During After

Working with othersAcademic clients through grant development

Research Design and Conduct Services/research courses and surgeries in the NHS

Access to other infrastructure groups (e.g. WHESS and Involving People)

Expansion and sustainabilityCost-recovery model allows expansion, development of ‘critical mass’ and flexibility to respond to changes and initiatives

Tapered-funding model supports move towards self-sustainability

Impact of core funding on capacity building (2)

Academic Health Science Collaboration: Research Methodology Support Scheme (CTUs embedded in regional hubs)

Research for Patient and Public Benefit Programme

NHS focused

CTUs driving activity at regional level

Standard competitive programmes – Research Funding Scheme, Fellowships, Studentships

Other support for capacity building

Contact details

For further enquiries please contact:

Michael Bowdery

NISCHR

Welsh Government

Cathays Park, Cardiff CF10 3NQ

Tel: 029 2082 5415

E-mail: Michael.Bowdery@wales.gsi.gov.uk

Northern IrelandDanny McAuley

Current update

• New Director

• Northern Ireland Clinical Trials Unit (NICTU)– Focus on CTU role

• UKCRC - CTU– Provisional Registration– Full Registration

Previous Organisational Structure

Snr Health Economist Snr Biostatistician Data Project Manager

Director

Data Processor

Health Economist Data ManagerBiostatistician

Jnr Biostatistician

QA Manager

Research Monitor

Trial Manager

Trial Co-ordinator

Snr Admin Ass

Gen Admin Ass

Admin AssDatabase Development & ICTMedical Physics Agency

New Organisational Structure

Director

CTU Manager

Snr Statistician QA Manager Snr Trial Manager Data Project ManagerICT Manager

Research MonitorsTrial Managers /

Trial Co-ordinatorsDatabase Developer Data Managers

Data Processors

Snr Health Economist

Biostatistician

Jnr Biostatistician

Health Economist

Clinical Trial Admin

Personal AssistantAdmin Assistant

Snr Research Monitor

Gen Admin Ass

Future Developments

• Development of CTU Team– Staff development and new staff

• CTU Portfolio– NIHR funded

• Development of CTU Management Systems