44% of patients reported increased stress in the past five years, and 15-40% of respondents also had other health issues (i.e. mood, chronic health conditions)3

share receptor activation

As precursors of endocannabinoids, omega-3 fatty acids are required for a healthy ECS. With balanced omega-3 levels, the body produces its own forms of active cannabinoids. If the ECS is out of balance, then an omega-3 deficiency is likely. If omega-3s are depleted or unavailable, dietary support with omega oils can help support omega-3 status. Additionally, dietary phytoactives support the body and direct activation of the CB1/CB2 receptor system.

ECS & OMEGA-3

CB2 • active in lymphatic system, immune cells & spleen• immunomodulatory • stress response• shared immunoresolving

Endocannabinoids(ECBs)

Metabolic Enzymes

Omega-6 derived

Omega-3derived

2-AGanandamide

ACTIVATION OF THEENDOCANNABINOID

SYSTEM (ECS)

phytocannabinoids

Memory

Sleep

Gut function & response

Metabolicprocesses

ECS FUNCTIONS

Healthy inflammation

responseOnly about 7.8% of adults and 1.1% children in the United States use supplements containing fish oil, omega-3s, and DHA or EPA2

60% of American adults have underlyingissues with inflammation1

1. RAND Health 2017

2. 2012 National Health Interview Survey

3. American Psychological Association 2010 Stress in America Survey

resolvins protectins maresins

EPEA DHEA

Balanced activation of both receptors is important but CB2 is preferred

Activation of Cannabinoid Receptors

(CB1, CB2)

CB1 • psychoactive stress,

mood & brain