BIOTRANSFORMATION , EXCRETION OF DRUG AND DETOXIFICATION
Contents
Introduction regarding DetoxificationBiotransformation DefinitionProcessSite of biotransformationPhase I/Phase II reactionsDrug metabolising enzymesFirst pass metabolismDrug EliminationDrug Excretion
Introduction regarding DetoxificationDetoxification definition:The metabolic process by which toxins are changed into less toxic or more readily excreted substances.
Why is it required???Steps for detoxification of drugs in bodyBiotransformation- metabolismDrug eliminationDrug excretion
Site of Biotransformation
Factor Affecting Drug Metabolism
Age Disease Species Differences Gender Pregnancy Environmental Drug Dose Enzyme Induction Enzyme Inhibition Diet Heredity/GeneticsDRUG METABOLISM
Classification of Biotransformation Reactions
conclusion
First Pass Metabolism
DRUG ELIMINATIONElimination of a drug
First order zero order
Plasma half-life The Plasma half-life of a drug is the time taken for its plasma concentration to be reduced to half of its original value.elimination t1/2 is t1/2 = k
DRUG EXCRETIONUrine : Through kidneysGlomerular Filtration:-Tubular ReabsorptionTubular secretion
Faeces : - eg. Erythromycin, ampicillinAir :eg- general anesthetics, paraldehyde Saliva and sweat:-eg. Lithium , thiocyanates, rifampin Milk :-more lipid soluble and less protein boundHofmann elimination ByDr. Ritu MathurDate 27 th august, 2013
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