P

LPS Stimulated MAPK Signaling

LBP

CD

14

LPS

Rac1

PAK1

MEKK1/4

MEK1/2

Raf1

CDC42PC-PLC

ASK1 TAK1

PKC

PI3K

NIK

IKKsIBs

PP P P

c-Junc-Fos c-Jun ATF2

P PP

PP

P

NF-B

Elk1 SRFCREB

ATF1 NF-B

IBsDegradation

TLR4

MKK3/4/6

p38

ERK1/2

JNK1/2

SRESRE

CRECRE

GeneExpression

GeneExpression

Ras