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LIVER FUNCTION TESTSDr. Vijay Marakala , M.B.B.S, M.D.BIOCHEMISTRYSIMS & RC
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Functions of liverClassification of LFT
FUNCTIONS OF LIVER
CLASSIFICATION OF LIVER FUNCTION TESTS
According to function of liverClassification of LFTTests based on synthetic function
Tests based on excretory function
Tests based on detoxification function
Tests based on metabolic function
Determination of serum enzymes
I IIIII IV V
I. Tests based on excretory function
II. Tests b/o detoxification function
III. Tests b/o synthetic function
Tests related to CARBOHYDRATE metabolismTests related to LIPID metabolismTests related to PROTEIN metabolism
IV. Tests b/o metabolic function
Galactose tolerance testSerum cholesterolSerum proteinsAminoaciduria
V. Enzymes in diagnosis of liver disease
I. Tests based on excretory function
I. Tests based on excretory function
I. Tests based on excretory function1.Serum bilirubin
Serum bilirubin estimation is based on van den Bergs diazo reaction.Diazo reagent consists of diazotized sulfanic acidDetermination of Serum Bilirubin
I. Tests based on excretory function
I. Tests based on excretory function
I. Tests based on excretory function
Laboratory results S BilirubinU UrobilinogenU BilirubinF UrobilinogenConjugated UnconjugatedNormal 0.1-0.4mg/dl0.2-0.7mg/dl0.4mg/dayAbsent40-280mg/dayPrehepatic NormalIncreased IncreasedAbsentIncreased Hepatic IncreasedIncreasedN/Decreased Present Decreased Posthepatic IncreasedNormalAbsent Present Trace to absent
I. Tests based on excretory function
Tests b/o detoxification function
Liver is the main source of synthesis of Plasma proteins - Albumin - Globulin(except )Blood clotting factors - Prothrombin and factors V, VII and X. Tests b/o synthetic function
Determination of serum albumin and globulinAlbumin/globulin ratio= 1.2:1 to2.5:1
Determination of Prothrombin time
Tests related to CARBOHYDRATE metabolismTests related to LIPID metabolismTests related to PROTEIN metabolism
Tests b/o metabolic function
Galactose tolerance testSerum cholesterolSerum proteinsAminoaciduria
In liver cell injury, damage to the membrane of cells and organelles allows intracellular enzymes to leak into the blood.Where their elevated concentrations can be measuredEnzymes in diagnosis of liver disease
Serum transaminasesAST or SGOT=
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