Genes and Function: The Rewriting of our <br />Textbooks of Pathology

Presented By David Hafler at 2014 ASCO Annual Meeting

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Presented By David Hafler at 2014 ASCO Annual Meeting

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Presented By David Hafler at 2014 ASCO Annual Meeting

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Presented By David Hafler at 2014 ASCO Annual Meeting

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Presented By David Hafler at 2014 ASCO Annual Meeting

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Presented By David Hafler at 2014 ASCO Annual Meeting

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Presented By David Hafler at 2014 ASCO Annual Meeting

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Presented By David Hafler at 2014 ASCO Annual Meeting

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Presented By David Hafler at 2014 ASCO Annual Meeting

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Presented By David Hafler at 2014 ASCO Annual Meeting

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Presented By David Hafler at 2014 ASCO Annual Meeting

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Presented By David Hafler at 2014 ASCO Annual Meeting

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Presented By David Hafler at 2014 ASCO Annual Meeting

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Presented By David Hafler at 2014 ASCO Annual Meeting

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Presented By David Hafler at 2014 ASCO Annual Meeting

Glioblastoma multiforme

Presented By David Hafler at 2014 ASCO Annual Meeting

Treatments

Presented By David Hafler at 2014 ASCO Annual Meeting

WHO Classification

Presented By David Hafler at 2014 ASCO Annual Meeting

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Presented By David Hafler at 2014 ASCO Annual Meeting

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Presented By David Hafler at 2014 ASCO Annual Meeting

PD-1 Expression CD4 T effectors in on Glioblastoma

Presented By David Hafler at 2014 ASCO Annual Meeting

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Presented By David Hafler at 2014 ASCO Annual Meeting

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Presented By David Hafler at 2014 ASCO Annual Meeting

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Presented By David Hafler at 2014 ASCO Annual Meeting

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Presented By David Hafler at 2014 ASCO Annual Meeting

Patient survival linked to Tumor-associated Tregs

Presented By David Hafler at 2014 ASCO Annual Meeting

Increase numbers of regulatory T Cells in Glioblastoma

Presented By David Hafler at 2014 ASCO Annual Meeting

Tregs and CD4 T effector cells in glioblastoma are Tim3+PD-1+

Presented By David Hafler at 2014 ASCO Annual Meeting

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Presented By David Hafler at 2014 ASCO Annual Meeting

PD-1+Tim3+ Tregs restricted to grade 4 glioblastoma

Presented By David Hafler at 2014 ASCO Annual Meeting

Absence of Tim3+PD-1+ Tregs in the blood of healthy controls

Presented By David Hafler at 2014 ASCO Annual Meeting

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Presented By David Hafler at 2014 ASCO Annual Meeting

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Presented By David Hafler at 2014 ASCO Annual Meeting

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Presented By David Hafler at 2014 ASCO Annual Meeting

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Presented By David Hafler at 2014 ASCO Annual Meeting

Blocking monoclonal antibodies increase CD4 T effector proliferation but not Treg suppression

Presented By David Hafler at 2014 ASCO Annual Meeting

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Presented By David Hafler at 2014 ASCO Annual Meeting

Impaired suppression by GBM-Treg and proliferative response by GBM-Teff

Presented By David Hafler at 2014 ASCO Annual Meeting

PD-1+Tim3+ Tregs have decreased suppressor function

Presented By David Hafler at 2014 ASCO Annual Meeting

PD-1+ CD4 effector cells and Tregs have shortened telomeres

Presented By David Hafler at 2014 ASCO Annual Meeting

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Presented By David Hafler at 2014 ASCO Annual Meeting

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Presented By David Hafler at 2014 ASCO Annual Meeting

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Presented By David Hafler at 2014 ASCO Annual Meeting