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New polymeric sulfide-borane complexes: convenient
hydroborating and reducing reagents
Journal: Journal of Sulfur Chemistry
Manuscript ID: Draft
Manuscript Type: Research Article
Date Submitted by the Author:
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Complete List of Authors: El-Hiti, Gamal; Cardiff University, School of Chemistry Smith, K; Cardiff University Balakit, Asim; Cardiff University, Chemistry Pardasani, R; University of Rajasthan
Keywords: polysulfides, borane adducts, hydroboration, reduction, carbonyl compounds
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Scheme 1.cdx Scheme 2.cdx Scheme 3.cdx Graphical Abstract.doc Tables.doc
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*Corresponding author. Tel: +44(2920)870600;;Fax: +44(2920)870600. † Permanent address: Chemistry Department, Faculty of Science, Tanta University, Tanta 31527, Egypt
New polymeric sulfide-borane complexes: convenient hydroborating and
reducing reagents
Keith Smith,*a Asim A. Balakit,a Ramchand T. Pardasanib and Gamal A. El-Hiti*a†
a School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff UK CF10
3AT. E-mail: [email protected], [email protected]; b Department of
Chemistry, University of Rajasthan, Jaipur - 302 055, India
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Abstract: New polymeric borane adducts have been synthesized from polymeric sulfides,
which are solids with a minimal odour. The adducts contain a high concentration of
borane, have significant stability and are soluble in THF. They act as hydroborating and
reducing reagents with behaviour similar to that of borane-methyl sulfide, making them
attractive borane sources.
Keywords: polysulfides, borane adducts, hydroboration, reduction, carbonyl compounds
Introduction
Borane complexes are highly versatile reagents with numerous applications in organic
syntheses and industrial processes (1-3). The most commonly used are borane-
tetrahydrofuran (BH3.THF) (4) and borane-dimethyl sulfide (BH3.SMe2, BMS) (5).
However, both these reagents possess certain unfavourable characteristics (5). BH3.THF is
commercially available only as a dilute solution, 1.0 M in BH3, and it also undergoes slow
cleavage of THF at room temperature. BMS is free from these disadvantages, as it is a
neat complex, 10.0 M in BH3, can be used in a variety of solvents and is highly stable.
However, BMS liberates a stoichiometric amount of water-insoluble dimethyl sulfide,
which has an obnoxious odour, high volatility and inflammability, thereby creating
environmental and safety problems, particularly for large scale use. This prompted Brown
and co-workers (6) in 1992 to introduce 1,4-oxathiane as a less volatile carrier for borane.
Subsequently, the Brown group demonstrated the utility of a series of liquid organic
sulfides (7) as borane carriers, bis(hydroxymethyl)sulfide (8) possessing the additional
advantage of being water soluble. More recently, Crich et al. (9) have described
2-(perfluorooctyl)ethyl methyl sulfide as a recyclable borane carrier. A few solid borane
complexes with bis-sulfides (2a) have also been patented. Clearly there is a strong desire
for safe borane carriers that can be easily handled. However, to be attractive as
replacements for the commonly used complexes, alternative adducts must be fairly high in
borane content (to avoid having to transport large quantities), be stable enough for long
term storage, have distinct advantages in terms of handling (e.g. avoiding obnoxious
odours, avoiding high flammability or allowing easy recovery of the carrier), be relatively
inexpensive, and match borane-THF or BMS in terms of reactivity profile. To date, no
other complex has fulfilled these criteria sufficiently well to rival the common complexes.
Polymer-bound borane complexes offer the possibility of stable and easily handled
materials of low volatility, with minimal odour and with easily recoverable polymeric
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carrier. Indeed, a number of polymer-bound complexes have been reported, including BH3
complexes of several cross-linked polymeric sulfides (10), a cross-linked
poly(4-vinylpyridine)-borane complex in which the borane content was up to 7.8 mmol/g
(11), and borane and haloborane complexes of poly(propylene sulfide) grafted onto cross-
liked polystyrene (12). Although all of these reagents have been used for hydroboration of
alkenes and/or reduction of aldehydes and ketones to produce the corresponding alcohols,
acid catalysis was required in the case of the poly(vinylpyridine) complex (13). Thus, its
reactivity profile is significantly different (and less useful) than that of borane-THF or
BMS, so it cannot be viewed as a potential replacement. A similar situation pertains with
polymer-supported ethylenediamine borane complexes prepared using a Merrifield resin
or a 1,6-hexanediol diacrylate-cross-linked polystyrene resin (14). These materials have
been used for reduction of aldehydes to the corresponding alcohols in high yields at room
temperature, but the concentration of borane in the complexes is already low and the use
of a two molar excess of the polymeric reagent was required (14). However, the polymer
could be regenerated easily and reused without loss in reactivity.
The borane content of the grafted poly(propylene sulfide) complex was also low
(around 2.44 mmol BH3/g) (12). A higher borane content (up to 7.05 mmol BH3/g of
polymer) was claimed for a homo (polypropylene sulfide) complex, but this material was
prepared and used only as a dilute solution in dichloromethane and it is not clear whether
removal of the solvent would have left a solid with such a high concentration of borane
(12). There are no reports of these complexes ever having been utilised, possibly because
of the low borane content of the solid borane-polymer complex and the inconvenience of
transporting a dilute solution of the homo poly(propylene sulfide)-borane complex.
Our long-standing interests in the use of solids in green methodologies (15) and in
boron chemistry (16) led us to consider the possibility of other polymeric sulfides as
suitable borane carriers. In particular, we wished to develop complexes possessing high
molarity in BH3, based on solids that are easy to prepare, convenient to handle, have mild
odour and low volatility, and are environmentally benign. We now report the results of our
efforts to develop such reagents.
Results and Discussion
Polymeric sulfides 1-6 were synthesised based on literature procedures (17). Unlike
poly(propylene sulfide) these contain unbranched alkylene chains. The complexing ability
of the polymers towards borane was investigated by bringing them into contact with
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BH3.THF or diborane gas using four procedures: (i) reaction of neat solid sulfide 1-6 with
BH3.THF; (ii) reaction of neat polymer with diborane gas; (iii) reaction of a solution of the
polymeric material with BH3.THF; and (iv) reaction of a solution of the polymeric
material with diborane gas. Interestingly, and uniquely, no uptake of borane to give
complex 7 was observed for the sulfide 1 (n = 2) under any of the conditions tried. This
was surprising in view of the reported uptake of up to 7 mmol/g of borane by
poly(propylene sulfide), which is simply a methyl-substituted version of this polymer. The
other linear polymeric sulfides (2-6) all absorbed significant quantities of borane by all of
the procedures, and, after considerable experimentation it was found that passage of
diborane gas, generated from BF3.OEt2 and sodium borohydride (18), into a solution of
the polymeric sulfide (3 g) in dichloromethane (20 mL) at room temperature was the most
convenient method for producing the corresponding borane adducts 8-12 (Scheme 1). In
this procedure the adducts precipitated, but were not separated by filtration or decantation.
Instead, the solvent was removed by blowing nitrogen over the mixture to leave the solid
adducts. Table 1 gives their borane content and 11B NMR data.
Scheme 1 here
Table 1 here
The effect of other solvents in this procedure was also tested. Adducts resulting
from reaction in chloroform or diglyme possessed a hydride content that was lower by
about 10% than for complexes formed in dichloromethane. Use of more dilute
dichloromethane solutions also resulted in lower hydride content of the precipitated
complexes. The gas analysis of adducts 8-12 indicated that around two-thirds of the total
sulfur atoms had been coordinated with borane. The 11B NMR spectra of all complexes
showed a single resonance at δ -20.8 to -20.9 ppm consistent with the formation of the
adducts.
The borane adducts 8-12 were white powders at room temperature and exhibited a
very mild ‘borane’ odour when transferred in air. They were soluble in THF, which is
typically used for hydroboration and reduction reactions. They appeared to be stable over
long periods under nitrogen (there was no change in borane content after three weeks at
room temperature under nitrogen and no visible change even after one year under
nitrogen). They were fairly stable even in air, decomposing only slowly on standing in air
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at room temperature. The stability of the complexes in air was readily ascertained by
recording infra-red spectra at regular intervals (from 5 minutes to 24 h). Two distinct
peaks at 2398 and 1095 cm-1, which may be attributed to B-H and B-S stretching
vibrations, respectively (19), appeared in the spectra of freshly prepared pure samples of
the complexes. No peak around 3200 cm-1 corresponding to boric acid was observed
initially. After samples had stood for 4 hours in air the peaks at 2398 and 1095 cm-1 began
to diminish noticeably and a strong peak around 3200 cm-1 began to appear, thereby
indicating hydrolysis of the adduct. On prolonged standing the solid began to darken. This
significant stability enabled the solid borane adducts to be weighed on a simple balance
without protection from air. Their very mild odours were further indication that they did
not release borane readily. These features and their reasonable solubilities make them
potentially attractive and easy-to-handle reagents.
To establish the synthetic applicability of the new borane complexes,
hydroboration-oxidation of alkenes was studied. Initially hydroboration-oxidation of
1-octene (Scheme 2; R = n-C6H13) in THF at room temperature was conducted with the
borane adducts 8-12 for 4 h. In each case a high yield (by GC) of a mixture of 1- and
2-octanol was obtained, indicating that the reactivities of the new borane adducts were
comparable to those of BMS (4) and BH3-THF (20). Thus, hydroboration of other
representative alkenes was conducted initially with 8 as the borane adduct (Scheme 2).
Adduct 8 was chosen because its polymer’s repeating unit has the lowest relative mass, so
that its borane content is higher in mass terms than the others. The results are recorded in
Table 2.
Scheme 2 here
Table 2 here
The procedure involved addition of an alkene (9.0 mmol) to the solution of borane
complex (3.6 mmol of BH3) in THF at 0-5 °C followed by stirring for 4 h and then
oxidative work up with alkaline hydrogen peroxide. The alcohols produced were analysed
by GC. The yields of alcohols obtained were in the range of 61-86%.
A series of experiments was conducted in order to find conditions under which
higher yields of alcohols could be obtained. It was found that use of a longer reaction time
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(16 h) gave satisfactory results. Therefore, the procedure was applied to a range of
alkenes. The results obtained are recorded in Table 3.
Table 3 here
Reactions conducted over this longer reaction period gave good yields (84-99%).
The regioselectivities of hydroboration of 1-hexene and styrene were similar to those
reported for BMS (5) and BH3-THF (21). Thus, hydroboration of 1-hexene formed 1- and
2-hexanols in the ratio of 84:4, while styrene gave 1- and 2-phenylethanols in the ratio
79:12. Hydroboration of 1-methylcyclohexene produced trans-2-methylcyclohexanol in
essentially quantitative yield. The adduct 8 therefore functioned very similarly to BMS in
hydroboration reactions, but with the significant advantage that the reactions are odour
free and do not liberate dimethyl sulfide.
To establish further the synthetic potential of the new borane adduct 8, reduction of
representative organic functional groups was studied (e.g. Scheme 3 for reduction of
aldehydes and ketones) and the results are recorded in Table 4.
Scheme 3 here
Table 4 here
The procedure adopted was to add a standard solution of the organic compound in
THF to an appropriate quantity of complex in THF at 0 °C and then reflux the mixture for
4 h. The excess borane was then quenched with methanol and the product was analysed by
GC. Reduction of most substrates was straightforward and gave high yields (85-100%) of
the corresponding alcohols, similar to BMS (21, 22). Although the reactions were carried
out under standard conditions of reflux for 4 h, such forcing conditions were often not
necessary. However, the reduction of benzamide was slow and only a 66% yield of
benzylamine was obtained even after a longer reaction time (16 h).
The sulfide polymer could be recovered following either hydroboration or
reduction reactions. The polymeric material 2 was precipitated as a white solid by the
addition of diethyl ether during the work-up process and was removed by filtration. It was
washed with a saturated solution of sodium hydroxide to remove any boric acid, then
washed thoroughly with water and left to dry in a vacuum oven. The recovered polymer
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was reused again to prepare 8. The adduct obtained was virtually identical to the initial
one. It had the same borane content and showed the same behaviour when used as a
hydroborating and reducing agent.
Our attention was next turned to use of borane adduct 11, to test whether it showed
any significant differences in activity compared to 8. Adduct 11 was tested in
hydroboration of representative alkenes and reduction of representative carbonyl
compounds under conditions similar to those used with adduct 8 (Schemes 2 and 3,
respectively). The results obtained are recorded in Tables 5 and 6, respectively.
Table 5 here
The results recorded in Table 5 clearly indicated that adduct 11 can be used as a
hydroborating agent. The small variations in yields obtained compared with those
obtained from similar reactions involving use of adduct 8 may be due to losses during
work-up. However, the selectivities observed were entirely comparable. For example,
hydroboration of 1-octene produced a mixture of 1- and 2-octanols in 77 and 4% yields,
respectively, compared to 81 and 4%, respectively, with adduct 8. Similarly with styrene,
1- and 2-phenylethanols were formed in the ratio of 84:13, similar to the 79:12 ratio
obtained with adduct 8).
Table 6 here
Table 6 shows that adduct 11 can also be used as a reducing reagent for various
carbonyl compounds to produce the corresponding alcohols in high yields (84-100%).
Again, the reactions were carried out under standard conditions at reflux for 4 h, although
not all examples needed such forcing conditions.
Conclusions
In conclusion, borane adducts derived from polymeric sulfides are solids of high hydride
content that can be readily weighed in air. Their mild smell, good solubility in THF, and
reactivity comparable to that of BMS, make them attractive borane sources. Consequently,
complex 8, in particular, is a highly promising, new hydroborating reagent, which might
well be suitable for large scale industrial application.
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Experimental Section
General. All reactions were performed under a nitrogen atmosphere. Glassware was oven
dried, assembled hot and allowed to cool under a stream of nitrogen gas. All reagents were
purchased from commercial sources and used as received. THF was distilled from sodium
benzophenone ketyl and other solvents were purified by standard procedures (23). Infra-
red spectra were recorded on a Perkin Elmer Spectrum One FT-IR spectrometer. 1H and 11B NMR spectra were recorded on a Bruker AV400 spectrometer operating at 400 MHz
for 1H or 128 MHz for 11B measurements. Chemical shifts δ are reported in parts per
million (ppm) relative to TMS and BF3.Et2O, respectively. GC analyses were carried out
on a Shimadzu Gas Chromatograph fitted with a ZEBRON ZB-5 (5% phenyl
polysiloxane) 30 m length column. The GC conditions used for analysis were: 40 °C for 1
min, ramped to 250 °C at 20 °C/min and held for 3 min. The injection temperature was
250 °C and the detection temperature 250 °C. Hexadecane was used as a GC standard.
Microanalyses were performed by Warwick analytical service at the University of
Warwick.
Borane adducts: typical experimental procedure for preparation of borane adduct 8
Diborane gas generated by reaction of sodium borohydride (5.67 g, 0.15 mol) in diglyme
(50 mL) with BF3.Et2O (24.5 mL, 0.20 mol) was passed slowly through a dichloromethane
(25 mL) solution of polymeric sulfide 2 (3.0 g) at room temperature over a period of 2 h.
Excess diborane was allowed to absorb in THF (15 mL) in a second bubbler. A white solid
precipitated out in the flask containing the polymer when passage of the borane gas was
nearing completion. The solvent was removed from the mixture by blowing with nitrogen.
The resulting borane-sulfide adduct 8 was analysed for active hydride by a standard
procedure (24) using THF:glycerol:3 M HCl (1:1:1) as the hydrolysing mixture. The ratio
of BH3 units to S atoms in the polymer was ca 0.68. δB (128 MHz, CDCl3; Me4Si) -20.9.
Hydroboration-oxidation of alkenes: typical procedure for hydroboration of
1-hexene with 8
In an oven dried 50 mL flask protected by a rubber septum was placed 8 (0.44 g, 3.6 mmol
BH3). The flask was cooled to 0 οC under a stream of nitrogen and freshly distilled THF
(14 mL) was added. 1-Hexene (0.757 g; 9.0 mmol) was added and the mixture was stirred
at 0 οC for 30 min and then at room temperature for 16 h. The reaction mixture was cooled
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to 0 οC and NaOH (3.0 M, 3.0 mL) was added, followed by slow addition of hydrogen
peroxide (30%, 3.5 mL). The contents were further stirred at room temperature for 1 h to
ensure complete oxidation. Hexadecane (0.75 g) was added followed by addition of
diethyl ether (10 mL) to precipitate the liberated polymeric sulfide. GC of the organic
layer showed that the combined yield of 1- and 2-hexanols was 84% in ca 80:4 ratio.
Reduction of functional groups: typical procedure for reduction of benzaldehyde
with 8
A 50 mL two neck flask equipped with a reflux condenser and a magnetic bar was flushed
with nitrogen and charged with 8 (0.24 g, 2.0 mmol BH3) and cooled to 0 οC. THF (10
mL) was added and the resulting colourless solution was cooled to 0 °C. Benzaldehyde
(0.53 g; 5.0 mmol) was then added dropwise. The reaction mixture was stirred at 0 °C for
30 min and a further 4 h under reflux conditions. The flask was then cooled to 0 °C and
methanol (3 mL) was added to quench any excess borane. Subsequently, diethyl ether (10
mL) was added to precipitate the released polymeric sulfide. GC analysis of the organic
layer showed the formation of benzyl alcohol (100%). The organic layer from the reaction
was washed with brine (3 x 20 mL), and most of the solvent was removed under vacuum.
Hexane (10 mL) and ether (10 mL) were added to the residue, which precipitated further
polymeric material. The polymer was filtered off and the filtrate was dried (MgSO4). The
solvent was removed under reduced pressure to give benzyl alcohol (0.0.45 g, 4.17 mmol;
83%) as a colourless oil identical to an authentic sample.
Acknowledgements
We thank the Iraqi Government and Cardiff University for financial support.
References
(1) (a) Pelter, A.; Smith, K.; Brown, H.C. Borane Reagents, Academic Press, London,
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(2) (a) Follet, M. Chem. Ind., 1986, 123-128. (b) Lane, C.F. Aldrichim. Acta 1973, 6,
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Org. Process Res. Dev. 2007, 11, 210-214.
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(3) (a) Brown, H.C.; Heim, P.; Yoon, N.M. J. Am. Chem. Soc. 1970, 92, 1637-1646.
(b) Zaidlewicz, M.; Brown, H.C. In Encyclopedia of Reagents for Organic
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Org. Chem. 1971, 36, 2388-2389. (b) Lane, C. F. J. Org. Chem. 1974, 39, 1437-
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(9) Crich, D.; Neelamkavil, S. Org. Lett. 2002, 4, 4175-4177.
(10) Crosby, G.A. US Pat., 1975, 3,928,293.
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(14) Rajasree K.; Devaky, K.S. J. Appl. Polym. Sci. 2001, 82, 593-600.
(15) See, for example: (a) Smith, K. Solid Supports and Catalysts in Organic Synthesis,
Ellis Harwood, Chichester, UK, 1992. (b) Smith, K. Selectivity through the use of
Heterogeneous Catalysts, In Supported Catalysts and Their Applications, ed.
Sherrington, D.C.; Kybett, A.P. The Royal Society of Chemistry, Cambridge,
2001, pp. 233-241. (c) Delaude, L.; Laszlo, P.; Smith, K. Acc. Chem. Res. 1993,
26, 607-613. (d) Smith, K. Ajarim, M.D.; El-Hiti, G.A. Catal. Lett. 2010, 134,
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1700. (f) Smith, K.; El-Hiti, G.A. Curr. Org. Chem., 2006, 10, 1603-1625. (g)
Smith, K.; El-Hiti, G.A. Curr. Org. Synth. 2004, 1, 253-274. (h) Smith, K.; Ewart,
G.M.; El-Hiti, G.A.; Randles, K. R. Org. Biomol. Chem. 2004, 2, 3150-3154. (i)
Smith, K.; Roberts, S.D.; El-Hiti, G.A. Org. Biomol. Chem. 2003, 1, 1552-1559.
(j) Smith, K.; El-Hiti, G.A.; Jayne, A.J.; Butters, M. Org. Biomol. Chem. 2003, 1,
2321-2325. (k) Smith, K.; El-Hiti, G.A.; Jayne, A.J.; Butters, M. Org. Biomol.
Chem. 2003, 1, 1560-1564. (l) Smith, K.; Liu, C.-H. Chem. Commun. 2002, 886-
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887. (m) Smith, K.; Almeer, S.; Peters, C. Chem. Commun. 2001, 2748-2749. (n)
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Organometallics in Syntheses: Mannual, A. ed. Schlosser, M. 2nd ed., Wiley,
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DeBoos, G.A. J. Chem. Soc., Perkin Trans. 1 1999, 2807-2812. (c) Pelter, A.;
Smith, K.; Hutchings, M.G.; Rowe, K. J. Chem. Soc., Perkin Trans. 1 1975, 129-
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Trans. 1 1975, 138-142. (e) Pelter, A.; Hutchings, M.G.; Smith, K. J. Chem. Soc.,
Perkin Trans. 1 1975, 142-145. (f) Pelter, A.; Hutchings, M.G.; Smith, K.;
Williams, D.J. J. Chem. Soc., Perkin Trans. 1 1975, 145-150.
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Chambers, R.R. J. Am. Chem. Soc. 1948, 70, 993-998. (b) Marvel, C.S.; Aldrich,
P.H. J. Am. Chem. Soc. 1950, 72, 1978-1981.
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(19) Heal, H.G. J. Inorg. Nucl. Chem. 1960, 12, 255-258.
(20) Brown, H.C. Hydroboration, Benjamin, W. A. Inc., New York, 1962.
(21) Mincione, E. J. Org. Chem. 1978, 43, 1829-1830.
(22) (a) Lane, C.F.; Hyatt, H.L.; Daniels, J.; Hopps, H.B. J. Org. Chem. 1974, 39,
3052-3054. (b) Lane, C.F. Aldrichimica Acta. 1975, 8, 20-23. (c) Brown, H.C.;
Choi, Y.M.; Narasimham, S. J. Org. Chem. 1982, 47, 3153-3163.
(23) (a) Vogel’s Textbook of Practical Organic Chemistry, 5th ed.; Longman: Harlow,
1989. (b) Perrin, D.D.; Armarego, W.L.F. Purification of Laboratory Chemicals,
3rd ed.; Pergamon: Oxford, 1988.
(24) Brown, H.C.; Kramer, G.W.; Levy, A.B.; Midland, M.M. Organic Syntheses via
Boranes, Wiley-Interscience, New York, 1975.
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Table 1 Preparation of borane adducts 8-12 from the corresponding polymeric sulfides 2-6 according to Scheme 1a Polymeric sulfide Adductb n B/S ratio mmol BH3/g 2 8 3 0.68 8.17 3 9 4 0.65 6.69 4 10 5 0.65 5.85 5 11 6 0.67 5.36 6 12 8 0.68 4.44 a All adducts were prepared by passing diborane gas into a suspension of the polymeric sulfides (3 g) in dichloromethane (20 mL). b White powders at room temperature. c Ratio of BH3 molecules (estimated by measurement of hydrogen evolved on hydrolysis in THF:glycerol:3 M HCl (1:1:1) to S atoms present (measured by microanalysis).
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Table 2 Hydroboration-oxidation of alkenes with the borane adduct 8 in THF according to Scheme 2 at room temperature for 4 ha
Alkene Product Yield (%)b 1-octene 1-octanol 59
2-octanol 2 1-hexene 1-hexanol 71
2-hexanol 2 cyclopentene cyclopentanol 80 cyclohexene cyclohexenol 86 a Alkene (9.0 mmol) was added to a solution of 8 (ca. 3.6 mmol BH3) in THF (14 mL) at 0-5 οC and stirred for 4 h at room temperature. The mixture was oxidised at 0-5 οC using NaOH (3.0 M, 3.0 ml) and H2O2 (30%, 3.5 ml) followed by warming to room temperature for 1 h to ensure complete oxidation. b By GC analysis using hexadecane as internal standard.
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Table 3 Hydroboration-oxidation of alkenes with the borane adduct 8 in THF according to Scheme 2 at room temperature for 16 ha Alkene Product Yield (%)b
1-octene 1-octanol 81 2-octanol 4
1-hexene 1-hexanol 80 2-hexanol 4
styrene 2-phenylethanol 79 1-phenylethanol 12
1-methylcyclohexene trans-2-methylcyclohexanol 99 cyclopentene cyclopentanol 84 cyclohexene cyclohexenol 86 a Alkene (9.0 mmol) was added to a solution of 8 (ca. 3.6 mmol of borane) in THF (14 mL) at 0-5 οC and stirred for 30 min at 0 °C and 16 h at room temperature. The mixture was oxidised at 0-5 οC using NaOH (3.0 M, 3.0 mL) and H2O2 (30%, 3.5 mL) followed by warming to room temperature for 1 h to ensure complete oxidation. b By GC analysis using hexadecane as internal standard.
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Table 4 Reduction of functional groups with 8 in THF under reflux for 4 ha
Starting material 8 (mol. eq.) Product Yield (%)b
benzaldehyde 0.4 benzyl alcohol 100 2-hexanone 0.4 2-hexanol 94 caproic acid 1.2 1-hexanol 92 benzoic acid 1.2 benzyl alcohol 90 methyl benzoate 0.8 benzyl alcohol 99 butyl benzoate 0.8 benzyl alcohol 97 phenyl benzoate 0.7 benzyl alcohol 88 benzamidec 1.9 benzylamine 51 (66)d cyclohexene oxide 0.4 cyclohexanol 85 a Organic compound (5 mmol) was added to a solution of 8 in THF and the mixture was stirred at 0 °C for 30 min and then refluxed for 4 h. Methanol (3 mL) was added and the mixture was stirred for 15 min, then the product was extracted into diethyl ether (20 mL). b By GC analysis using hexadecane as internal standard. c After reaction HCl (1.0 M, 3 ml) was added and the mixture was refluxed, cooled to 0 οC, then diethyl ether (20 mL) and NaOH (pellets) were added to neutralize the solution followed by the separation of the organic layer. d The reaction time was 16 h.
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Table 5 Hydroboration-oxidation of alkenes with the borane adduct 11 in THF at room temperature for 16 ha Alkene Product Yield (%)b
1-octene 1-octanol 77 2-octanol 4
1-hexene 1-hexanol 73 2-hexanol 5
styrene 2-phenylethanol 84 1-phenylethanol 13
1-methylcyclohexene trans-2-methylcyclohexanol 83 cyclopentene cyclopentanol 88 a Alkene (9.0 mmol) was added to a solution of 11 (ca. 3.6 mmol BH3) in THF (15 mL) at 0-5 οC and was stirred for 30 min at 0 °C and for 16 h at room temperature. The reaction mixture was oxidised at 0-5 οC using NaOH (3.0 M, 3.0 mL) and H2O2 (30%, 3.5 mL) followed by warming to room temperature for 1 h to ensure complete oxidation. b By GC analysis with hexadecane as an internal standard.
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Table 6 Reduction of some carbonyl compounds with borane adduct 11 in THFa Entry Starting material 11 (mol. eq.) Product Yield (%)b 1 benzaldehyde 0.4 benzyl alcohol 100 2 2-hexanone 0.4 2-hexanol 84 3 caproic acid 1.1 1-hexanol 93 4 ethyl benzoate 0.8 benzyl alcohol 94 a Carbonyl compound (5.0 mmol) was added to a solution of 11 in THF and stirred at 0 °C for 30 min and refluxed for 4 h. Methanol (3 mL) was added and the mixture was stirred for 15 min then extracted with diethyl ether (20 mL). b By GC analysis using hexadecane as internal standard.
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BH3
(CH2)n S (CH2)n Sx
..
1-6 8-12
n = 2, 3, 4, 5, 6 and 8
B2H6 gasDCM, 2 h x
7 (n = 2) did not f orm
Scheme 1. Synthesis of the polymeric sulfide-borane adducts 8-12.
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RB
R
R
ROH
R R
OH
RB
R
R
++H2O2NaOH
8THF
major minormajor minor Scheme 2. Hydroboration-oxidation of alkenes with the borane adduct 8.
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8THFR1 R2
O
R1 R2
OH
H Scheme 3. Reduction of aldehydes and ketones with the borane adduct 8.
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List of Schemes Captions
Scheme 1. Synthesis of the polymeric sulfide-borane adducts 8-12.
Scheme 2. Hydroboration-oxidation of alkenes with the borane adduct 8.
Scheme 3. Reduction of aldehydes and ketones with the borane adduct 8.
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