Faculty Instrument Usage Seed Grant Research
at the Otto York Center
Particle Engineering & Pharmaceutical Nanotechnology Laboratory (PEPNAL)
(PI: Prof. Ecevit Bilgili, [email protected])
• Project: “Preparation & characterization of physically stable drug nanosuspensions for parenteral delivery & their conversion to redispersible nanocomposites via drying for oral delivery”
Preparation and delivery of drug nanoparticles orally and parenterally present unique stability challenges. Our proposed approaches:
1. Sterile-filterable nanosuspensions for long-acting parenteral & ophthalmic drug delivery
2. Redispersible dried nanocomposites for immediate release from solid oral dosages
Prior funding sources: FDA, NSF ERC, Catalent Pharma; Future funding: NSF IUCRC, Zydus, & other pharma companies
Ecevit Bilgili (Primary Inventor), Anagha Bhakay, Mohammad Azad, and Rajesh Dave. US Patent (2016) US 9,452,107.Afolawemi Afolabi, Olakemi Akinlabi, and Ecevit Bilgili. European Journal of Pharmaceutical Sciences 51 (2014) 75-86.Ecevit Bilgili and Afolawemi Afolabi. International Journal of Pharmaceutics 439 (2012) 193-206.
0 s 10 s 30 s 60 s
2.5% HPC/10% Mannitol
2.5% HPC/0.9% CCS Milled for 60 min
2.5% HPC/0.5% SDS
Surfactant-Free, Self-Redispersible, Nanocomposite
Microparticles for Fast Active Agent Delivery
Intensified Wet Milling for Preparation of Sub100 nm Drug
Particles and Sterile-filterable/Injectable Nanosuspensions
Nanosuspension Stabilization with Swellable Biopolymers
Title: Substrate-mediated Biotransformation and Defluorination of PFAS PI: Mengyan Li
Abstract: Per- and polyfluoroalkyl substances (PFAS) represent
a group of emerging contaminants with growing concern. This
project is aimed to investigate the biotransformation of
polyfluorinated precursors by heterotrophic bacteria. Effects of
different substrates will be evaluated to promote the optimal
defluorination. This study will ultimately enable the
development of green and cost-efficient remediation
techniques to mitigate the widespread PFAS contamination.
York Center Faculty Instrument Usage Seed Grants
Title: Nonoscale CMOS Devices and Nanowire Device Characterization
PI: Durga Misra
Abstract: This project characterizes Nanoscale CMOS devices andSemiconductor nanostructures. Electrical characterization includesNBTI, PBTI, SILC, TZDB, TDDB, interface states and low temperaturecharacterization. Defect Characterization of Thin-film (CdTe) andSilicon Solar Cells are also carried out. Nanowire InGaN/AlGaN lightemitting diodes are also characterized.
Current Funding: TEL Technology Center, America, LLC
York Center Faculty Instrument Usage Seed Grants
Title: NEW NON-PGM CATALYSTS FOR ELECTROCHEMICAL SYSTEMS
PI: Dr. Eon Soo Lee, Mechanical & Industrial Eng
Abstract: The goal of this research is to use non-precious metal materials such ascarbon, nitrogen, transition metal, and porous material to synthesize a new non-precious metal (non-PGM) catalyst for electrochemical systems and industrialcatalysis.
gas
supply
channel
s
Catalyst layer
MEA
Anode Cathode
Power
PEM
2H 2O
ee
H
GDLGDL
OH2
Power
York Center Faculty Instrument Usage Seed Grants
Title: Enhanced Riverbank Filtration with In-Situ Air Nano-bubbles Treatment
PI: Taha F. Marhaba & Ahmed K. Ahmed (PhD candidate)
John A. Reif, Jr. Department of Civil and Environmental Engineering, New Jersey Institute of Technology
Abstract: Surface water bodies are exposed to pollution as a result of discharging untreated liquid wastes from industrial, agricultural and domestic activities. Riverbank filtration (RBF) offers a cost-effective in-situ technique for producing treated water by removing suspended solids, pathogens, trace organics, bacteria, viruses, inorganic compounds and micro-pollutants. A novel method is being investigated in this research, which enhances the effectiveness of the RBF as a water treatment process. The in-situ process involves the injection of air Nano-bubbles injection during RBF. Laboratory pilots will be used to evaluate the process. Parameters evaluated include dissolved oxygen, hydraulic conductivity, UV254, SUVA, dissolved organic carbon, and some heavy metals (lead, Cadmium, Iron, Magnesium, Mercury).
Labs/Instruments:
York Center:
TOC Analyzer –combustion
ICPMS
Flame Atomic Absorption Spectrometer (Flame AA)
Water lab in Colton Hall :
Air Nano-bubbles generator
Turbidity meter
Dissolved Oxygen Meter
York Center Faculty Instrument Usage Seed Grants
Title: Chemical and Structural Characterization of ColloidalNanocomposite Thin Films
PI: Dong-Kyun Ko
Abstract: The overall goal of the project is to create a nanocomposite co-assembled from two different kinds of semiconductor nanocrystals withtargeted nearest-neighbor arrangement. This new class of performance-tailorednanomaterial will be used in advanced thermoelectric applications.
Harvesting body heat to generate electricity
York Center Faculty Instrument Usage Seed Grants
Title: Decontamination of Passaic River sediments using Ultrasoundand Ozone nano bubblesPI: Jay N. Meegoda, Janitha H Batagoda
Abstract: The industrialization has brought in so many manmade compounds inlarger concentrations into the Passaic river basin making it the second heavily pollutedriver in the United States. The objective of this study is to develop an in-situ remediationmethod using ozone nano-bubbles and ultrasound to treat the contaminated sediments.A set of laboratory scale experiments will be carried out using simulated dredgedsediments from the Passaic River to identify the impact of sonication time, sonicationpower, pH in water ozone concentration and temperature on oxidizing PAHs. Once thebaselines are established, the feasibility to use the proposed method for heavy metalsand other organic contaminants will be examined. The data extracted from thelaboratory experiments will be used to develop a field application of the technology. Theobservations from the pilot tests will be used to optimize the field application.
York Center Faculty Instrument Usage Seed Grants
Title: Gate Electrodes within Electrochemical Cells
PI: H. Grebel
Abstract: In order to control the ion flow in electrochemical cells we place gate electrodesbetween the anode and the cathode of the cell. By applying a bias potential to this gateelectrode, we are able to control the external current of the cell. This construction would bethe first step towards the realization of ion transistors. In preliminary studies, several gateelectrodes were considered: layers of functionalized carbon nanotubes (CNT) and metalplate capacitor. Cyclic voltammetry (CV) and Electrochemical Impedance Spectroscopy(EIS) revealed the effect of the gate bias on the effective capacitance and impedance of thecell. The proposed research project is aimed at understanding the mechanisms involved inthis gate construction. Surface morphology of the gate membranes will be analyzed usingscanning electron microscope (SEM) EDX and XRD. Raman spectroscopy will be used toassess the carbon nanotube gate membrane. Finally, we will use AFM to assess the gateelectrode thickness construction.
Left: The structure.
Blue - electrons; Red - ions.
Right: Raman spectra of the
structure. A small relative shift is
noted for the various peaks. 0
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1000 1500 2000 2500 3000R
am
an
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oun
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p-n at interface
n-type only
p-type only
Sustainable Nanotechnology for Energy & Environment Laboratory
Organic pollutants
Major research areas:
• Visible-light-Driven Photocatalytic Processes to Produce H2 and Remove
Water Pollutants
• Antibacterial Applications (e.g., water disinfection) and Toxicity
Assessment of Engineered Nanomaterials
• Biofuel-production and nutrient Recovery from Wastewater
• Reactive Ceramic/Polymer Membrane Development
Major funding sources:
NSF, DOE, USDA, and NSF Membrane Science Engineering and Technology
(MAST) Center.
algal
photobioreactor
WastewaterZhang, Wen, etc, ACS applied materials & interfaces 2015, Environmental Science &
Technology 2014; Bioresource technology 2014, 166, 266-272.
Wen Zhang, Ph.D., P.E.Assistant Professor, Dept of Civil and Environmental Engineering, NJIT
Office Phone: (973) 596-5520; Fax: (973) 596-5790; Email: [email protected]
York Center Faculty Instrument Usage Seed Grants
Title: ECTFE Membrane Characterization after Exposure to Different Operating Conditions
Study various properties and changes in ECTFE membranes subjected to solvent sorption, radiation exposure and pH variation*
(1) X-ray diffraction analysis
(2) Scanning electron microscopy
(3) Thermogravimetric analysis
(4) Raman spectroscopy**
Tempature (oC)
0 200 400 600 800
Wei
ght
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cent
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-20
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)
100020003000R
aman
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cps)
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(2)
(3) (4)
*Na Yao, John Chau, Ezinwa Elele, Boris Khusid,
Kamalesh K. Sirkar and Derek J. Dehn, Journal of
Membrane Science, 2017, 532, 89-104.
**Na Yao, Boris Khusid, Kamalesh K. Sirkar, and
Derek J. Dehn, Manuscript submitted for
publication, 2017.
2 theta (degree)
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Virgin
Methanol
Ethanol
2-propanol
1-butanol
THF
Acetonitirle
Toluene
TOA
(1)
Title: High Efficiency Deep Ultraviolet III-Nitride Nanowire Light-Emitters PI: Hieu P. T. Nguyen
Abstract: A compact, highly efficient, and high power ultraviolet (UV) light-source with emission
wavelengths below 350 nm has attracted great attention due to its wide range of applications. The
primary applications of such UV emitters include remote detection of biological and chemical compound,
cancer detection and fluorescence sensing or Raman spectroscopy. Moreover, UV LEDs and laser
diodes (LDs) offer great potential applications in data storage, high-speed communications, information
processing, optical interconnects. The main objective of this research program is to investigate the
molecular beam epitaxial growth and fabrication of III-nitride LEDs on Si and patterned substrates
operating in the ultraviolet (UV) wavelength region (from 210nm to 350nm).
SEM image of IIII-nitride nanowire
heterotructures on Si
Rajan Philip et al., Journal of Advanced Optics and Photonics, 1 (2018) 3
Djavid et al., Photonics and Nanostructures - Fundamentals and Applications, 28 (2018) 106
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